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Colonization of the cervicovaginal space with Gardnerella vaginalis leads to local inflammation and cervical remodeling in pregnant mice

. Methodology: Luz-Jeannette Sierra, Guillermo O. BarilaÂ. Project administration: Amy G. Brown. Supervision: Amy G. Brown, Louis J. Soslowsky, Michal A. Elovitz. 15 / 19 Writing ± original draft: Luz ... -Jeannette Sierra. Writing ± review & editing: Amy G. Brown, Lauren Anton, Michal A. Elovitz. 16 / 19 17 / 19 18 / 19 1. In: Behrman RE , Butler AS , editors. Preterm Birth: Causes , Consequences, and

Exposure to intrauterine inflammation alters metabolomic profiles in the amniotic fluid, fetal and neonatal brain in the mouse

Conceptualization: Michal A. Elovitz. Data curation: Amy G. Brown, Natalia M. Tulina. Formal analysis: Amy G. Brown, Natalia M. Tulina. Methodology: Amy G. Brown, Guillermo O. Barila. Supervision: Michal A ... . Elovitz. Writing ± original draft: Amy G. Brown. Investigation: Amy G. Brown, Natalia M. Tulina, Guillermo O. Barila, Michael S. Hester. Writing ± review & editing: Amy G. Brown, Natalia M. Tulina

Differential Methylation of Genes Associated with Cell Adhesion in Preeclamptic Placentas

Preeclampsia (PE), a hypertensive disorder of pregnancy, is hypothesized to be associated with, if not mechanistically related to abnormal placental function. However, the exact mechanisms regulating the pathogenesis of PE remain unclear. While many studies have investigated changes in gene expression in the PE placenta, the role of epigenetics in PE associated placental ...

Lipopolysaccharide induces cytokine production and decreases extravillous trophoblast invasion through a mitogen-activated protein kinase-mediated pathway: possible mechanisms of first trimester placental dysfunction

BACKGROUND Defects in extravillous trophoblast (EVT) function could contribute to placental dysfunction resulting in adverse obstetrical outcomes. Adverse obstetrical outcomes have been highly correlated with intrauterine infection; however, the mechanisms linking infection to placental dysfunction remain unclear. We investigated the effects of inflammation on EVT cytokine ...