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miRBase: annotating high confidence microRNAs using deep sequencing data

Ana Kozomara 0 Sam Griffiths-Jones 0 0 Faculty of Life Sciences, University of Manchester , Manchester , M13 9PT, UK We describe an update of the miRBase database (http://www.mirbase.org/), the

Target Repression Induced by Endogenous microRNAs: Large Differences, Small Effects

MicroRNAs are small RNAs that regulate protein levels. It is commonly assumed that the expression level of a microRNA is directly correlated with its repressive activity – that is, highly expressed microRNAs will repress their target mRNAs more. Here we investigate the quantitative relationship between endogenous microRNA expression and repression for 32 mature microRNAs in...

miRBase: integrating microRNA annotation and deep-sequencing data

Ana Kozomara 0 Sam Griffiths-Jones 0 0 Faculty of Life Sciences, University of Manchester , Michael Smith Building, Oxford Road, Manchester , M13 9PT, UK miRBase is the primary online repository for

Sex-Biased Expression of MicroRNAs in Schistosoma mansoni

Schistosomiasis is an important neglected tropical disease caused by digenean helminth parasites of the genus Schistosoma. Schistosomes are unusual in that they are dioecious and the adult worms live in the blood system. MicroRNAs play crucial roles during gene regulation and are likely to be important in sex differentiation in dioecious species. Here we characterize 112...