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Plasma metabolomics reveals membrane lipids, aspartate/asparagine and nucleotide metabolism pathway differences associated with chloroquine resistance in Plasmodium vivax malaria

, Jorge L. Salinas, Wuelton M. Monteiro, Fernando Val, Regina J. Cordy, Ken Liu, Gisely C. Melo, Andre M. Siqueira, Belisa Magalhaes, Marcus V. G. Formal analysis: Karan Uppal, Jorge L. Salinas, Ken Liu ... C. Melo, Andre M. Siqueira, Belisa Magalhaes, Mary R. Galinski, Marcus V. G. Lacerda, Dean P. Jones. Dean P. Jones. Galinski, Marcus V. G. Lacerda, Dean P. Jones. Methodology: Karan Uppal, Jorge L

Plasmodium vivax Landscape in Brazil: Scenario and Challenges

sustained and progressive control actions in this Latin American region. Received March 14, 2016. Accepted for publication August 19, 2016. Published online October 5, 2016. Authors’ addresses: Andre M ... . Siqueira, Instituto Nacional de Infectologia, Fundacao Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil, E-mail: . Oscar Mesones-Lapouble, Pan American Health Organization, Brasilia, Brazil, E-mail: oscar

Fixed-Dose Artesunate–Amodiaquine Combination vs Chloroquine for Treatment of Uncomplicated Blood Stage P. vivax Infection in the Brazilian Amazon: An Open-Label Randomized, Controlled Trial

Background. Despite increasing evidence of the development of Plasmodium vivax chloroquine (CQ) resistance, there have been no trials comparing its efficacy with that of artemisinin-based combination therapies (ACTs) in Latin America.