sustained and progressive control actions in this Latin American region. Received March 14, 2016. Accepted for publication August 19, 2016. Published online October 5, 2016. Authors’ addresses: Andre M ... . Siqueira, Instituto Nacional de Infectologia, Fundacao Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil, E-mail: . Oscar Mesones-Lapouble, Pan American Health Organization, Brasilia, Brazil, E-mail: oscar
Background. Despite increasing evidence of the development of Plasmodium vivax chloroquine (CQ) resistance, there have been no trials comparing its efficacy with that of artemisinin-based combination therapies (ACTs) in Latin America.