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The farnesoid X receptor agonist obeticholic acid upregulates biliary excretion of asymmetric dimethylarginine via MATE-1 during hepatic ischemia/reperfusion injury

editing assistance and Prof. Anthony Baldry for revising the English. Author Contributions Conceptualization: Andrea Ferrigno, Mariapia Vairetti. Formal analysis: Andrea Ferrigno, Laura Giuseppina Di ... Pasqua, Clarissa Berardo, Veronica Siciliano, Vittoria Rizzo. Funding acquisition: Plinio Richelmi. Methodology: Andrea Ferrigno, Laura Giuseppina Di Pasqua, Clarissa Berardo, Veronica Siciliano

Evaluation of ADMA-DDAH-NOS axis in specific brain areas following nitroglycerin administration: study in an animal model of migraine

Background Nitric oxide (NO) is known to play a key role in migraine pathogenesis, but modulation of NO synthesis has failed so far to show efficacy in migraine treatment. Asymmetric dimethylarginine (ADMA) is a NO synthase (NOS) inhibitor, whose levels are regulated by dimethylarginine dimethylaminohydrolase (DDAH). Systemic administration of nitroglycerin (or glyceryl...