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Role of Human Leukocyte Antigens (HLA) in Autoimmune Diseases

article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published. Disclosures. Gergely Bodis, Victoria Toth, and Andreas Schwarting have

Epigenetic Aspects of Systemic Lupus Erythematosus

interest. Manfred Relle, Bernd Fo¨hr, and Andreas Schwarting declare that they have no conflict of interest. Compliance with ethics guidelines. This article is based on previously conducted studies and does

The count of tender rather than swollen joints correlates with aortic stiffness in patients with rheumatoid arthritis

Background Patients with rheumatoid arthritis (RA) are at a higher cardiovascular (CV) risk in comparison to the general population. CV risk associates closely with aortic stiffness. Aim of this exploration was therefore to evaluate aortic stiffness in patients with RA and to examine its association with various RA associated parameters as well as with traditional CV risk factors...

First Real-World Insights into Belimumab Use and Outcomes in Routine Clinical Care of Systemic Lupus Erythematosus in Germany: Results from the OBSErve Germany Study

OBSErve Germany was the first observational study of belimumab as add-on treatment for systemic lupus erythematosus (SLE) in routine clinical care in Germany, retrospectively collecting data from 102 SLE patients, 6 months before and after belimumab initiation. Most patients had moderate or severe SLE and several SLE manifestations. After 6 months of belimumab treatment, 78% of...

Comparative analysis of procoagulatory activity of haemodialysis, haemofiltration and haemodiafiltration with a polysulfone membrane (APS) and with different modes of enoxaparin anticoagulation

Background. Treatment modalities of renal replacement therapy differ in their diffusive and convective mass transfer characteristics. It was the goal of this study to clarify whether an increase in convective mass transfer as performed with haemofiltration (HF) and haemodiafiltration (HDF) in comparison with high-flux haemodialysis (HD) is associated with an alteration in...

Proteinase-3 as the major autoantigen of c-ANCA is strongly expressed in lung tissue of patients with Wegener's granulomatosis

Proteinase-3 (PR-3) is a neutral serine proteinase present in azurophil granules of human polymorphonuclear leukocytes and serves as the major target antigen of antineutrophil cytoplasmic antibodies with a cytoplasmic staining pattern (c-ANCA) in Wegener's granulomatosis (WG). The WG disease appears as severe vasculitis in different organs (e.g. kidney, nose and lung). Little is...

Safety and clinical outcomes of rituximab therapy in patients with different autoimmune diseases: experience from a national registry (GRAID)

Andreas Schwarting Rdiger Eming Michael Hertl Rudolf Stadler Michael Schwarz-Eywill Siegfried Wassenberg Martin Fleck Claudia Metzler Uwe Zettl Jens Westphal Stefan Heitmann Anna L Herzog Heinz Wiendl