Search: authors:"Andrew Furey"

Macrophage migration inhibitory factor may play a protective role in osteoarthritis

Scholar Jieying Xiong View author publications You can also search for this author in PubMed Google Scholar Andrew Furey View author publications You can also search for this author in PubMed ... College of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada Liujun Chen & Dake Qi Discipline of Surgery, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada Andrew

Differential correlation network analysis identified novel metabolomics signatures for non-responders to total joint replacement in primary osteoarthritis patients

A classification modeling approach for determining metabolite signatures in osteoarthritis

: Weidong Zhang, Sergei Likhodii, Guang Sun, Andrew Furey, Edward Randell. Formal analysis: Jason S. Rockel, Weidong Zhang, Konstantin Shestopaloff, Kala Funding acquisition: Guangju Zhai, Mohit Kapoor ... . Rockel, Weidong Zhang, Konstantin Shestopaloff, Sergei Likhodii, Guang Sun, Andrew Furey, Edward Randell, Kala Sundararajan, Rajiv Gandhi, Guangju Zhai, Mohit Kapoor. 12 / 13 1. Oliveria SA , Felson DT

Does Open Reduction and Internal Fixation versus Primary Arthrodesis Improve Patient Outcomes for Lisfranc Trauma? A Systematic Review and Meta-analysis

BackgroundAlthough Lisfranc injuries are uncommon, representing approximately 0.2% of all fractures, they are complex and can result in persistent pain, degenerative arthritis, and loss of function. Both open reduction and internal fixation (ORIF) and primary fusion have been proposed as treatment options for these injuries, but debate remains as to which approach is better...

Hyperglycemia-related advanced glycation end-products is associated with the altered phosphatidylcholine metabolism in osteoarthritis patients with diabetes

: Guangju Zhai. Validation: Edward W. Randell, Guang Sun, Guangju Zhai. Writing ± original draft: Weidong Zhang. Writing ± review & editing: Edward W. Randell, Guang Sun, Sergei Likhodii, Ming Liu, Andrew ... Furey, Guangju Zhai. 8 / 10 9 / 10 1. Glyn-Jones S , Palmer AJ , Agricola R , Price AJ , Vincent TL , Weinans H , et al. Osteoarthritis. Lancet . 2015 ; 386 : 376 ± 387 . https://doi.org/10.1016/S0140

Overexpression of MMP13 in human osteoarthritic cartilage is associated with the SMAD-independent TGF-β signalling pathway

Introduction In vitro and animal model of osteoarthritis (OA) studies suggest that TGF-β signalling is involved in OA, but human data is limited. We undertook this study to elucidate the role of TGF-β signalling pathway in OA by comparing the expression levels of TGFB1 and BMP2 as ligands, SMAD3 as an intracellular mediator, and MMP13 as a targeted gene between human...

Genome-wide DNA methylation study of hip and knee cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in osteoarthritis

Evidence suggests that epigenetics plays a role in osteoarthrits (OA). The aim of the study was to describethe genome wide DNA methylation changes in hip and knee OA and identify novel genes and pathwaysinvolved in OA by comparing the DNA methylome of the hip and knee osteoarthritic cartilage tissues withthose of OA-free individuals. Cartilage samples were collected from hip or...

SMAD3 Is Associated with the Total Burden of Radiographic Osteoarthritis: The Chingford Study

Background A newly-described syndrome called Aneurysm-Osteoarthritis Syndrome (AOS) was recently reported. AOS presents with early onset osteoarthritis (OA) in multiple joints, together with aneurysms in major arteries, and is caused by rare mutations in SMAD3. Because of the similarity of AOS to idiopathic generalized OA (GOA), we hypothesized that SMAD3 is also associated with...