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11 papers found.
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Characterization of intercellular communication and mitochondrial donation by mesenchymal stromal cells derived from the human lung

Background Bone marrow-derived mesenchymal stromal cells (BM-MSCs) are capable of repairing wounded lung epithelial cells by donating cytoplasmic material and mitochondria. Recently, we characterized two populations of human lung-derived mesenchymal stromal cells isolated from digested parenchymal lung tissue (LT-MSCs) from healthy individuals or from lung transplant recipients...

A 20-year multicentre outcome analysis of salvage mechanical circulatory support for refractory cardiogenic shock after cardiac surgery

Khorsandi 0 Scott Dougherty 1 Andrew Sinclair Keith Buchan Fiona MacLennan Omar Bouamra Philip Curry Vipin Zamvar 0 Geoffrey Berg Nawwar Al-Attar 0 Department of Cardiothoracic Surgery, Royal Infirmary of

Identification of candidate gonadal sex differentiation genes in the chicken embryo using RNA-seq

Background Despite some advances in recent years, the genetic control of gonadal sex differentiation during embryogenesis is still not completely understood. To identify new candidate genes involved in ovary and testis development, RNA-seq was used to define the transcriptome of embryonic chicken gonads at the onset of sexual differentiation (day 6.0/stage 29). Results RNA-seq...

Mammalian sex determination—insights from humans and mice

Stefanie Eggers Andrew Sinclair Abbreviations ACD AMH AR Responsible Editors: Tariq Ezaz and Jennifer Graves. 0 ) Murdoch Children's Research Institute, Royal Children's Hospital and Department of

Open urethroplasty versus endoscopic urethrotomy - clarifying the management of men with recurrent urethral stricture (the OPEN trial): study protocol for a randomised controlled trial

Stephenson et al. Trials Rachel Stephenson 5 Sonya Carnell 5 Nicola Johnson 5 Robbie Brown 5 Jennifer Wilkinson 5 Anthony Mundy 3 Steven Payne 2 Nick Watkin 9 James N'Dow 8 Andrew Sinclair 7 Rowland ... Foundation Trust; Andrew Baird, Aintree University Hospitals NHS Foundation Trust, Liverpool; Andrew Sinclair, Stockport NHS Foundation Trust; Rajeshwar Krishnan, East Kent Hospitals University NHS Foundation

Disorders of sex development: insights from targeted gene sequencing of a large international patient cohort

Background Disorders of sex development (DSD) are congenital conditions in which chromosomal, gonadal, or phenotypic sex is atypical. Clinical management of DSD is often difficult and currently only 13% of patients receive an accurate clinical genetic diagnosis. To address this we have developed a massively parallel sequencing targeted DSD gene panel which allows us to sequence...

Eleven years of sexual discovery

A report on Novartis Foundation Symposium 244 "The Genetics and Biology of Sex Determination", London, UK, 1-3 May 2001.

Rapid Development of Non-Alcoholic Steatohepatitis in Psammomys obesus (Israeli Sand Rat)

Background and Aims A major impediment to establishing new treatments for non-alcoholic steatohepatitis is the lack of suitable animal models that accurately mimic the biochemical and metabolic characteristics of the disease. The aim of this study was to explore a unique polygenic animal model of metabolic disease as a model of non-alcoholic steatohepatitis by determining the...

Copy Number Variation in Patients with Disorders of Sex Development Due to 46,XY Gonadal Dysgenesis

Disorders of sex development (DSD), ranging in severity from mild genital abnormalities to complete sex reversal, represent a major concern for patients and their families. DSD are often due to disruption of the genetic programs that regulate gonad development. Although some genes have been identified in these developmental pathways, the causative mutations have not been...