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42 papers found.
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The Prophetic Vision of Robocop 3

With this paper, I reviewed the final installment of the Robocop movie trilogy through a satirical, post-Occupy Wall Street lens.

A single rapamycin dose protects against late-stage experimental cerebral malaria via modulation of host immunity, endothelial activation and parasite sequestration

Maladaptive immune responses during cerebral malaria (CM) result in high mortality despite opportune anti-malarial chemotherapy. Rapamycin, an FDA-approved immunomodulator, protects against experimental cerebral malaria (ECM) in mice through effects on the host. However, the potential for reduced adaptive immunity with chronic use, combined with an incomplete understanding of...

Is treatment for bipolar disorder more effective earlier in illness course? A comprehensive literature review

Background We aimed to investigate a key element of the early intervention approach; whether treatment at an earlier stage of bipolar disorder is more effective than later in its course. Methods A comprehensive literature review using Medline, Embase, Psychinfo, PsycArticle and Web of Science as data sources, with a subsequent narrative synthesis. Study quality was assessed using...

Drug therapy for alcohol dependence in primary care in the UK: A Clinical Practice Research Datalink study

Aim To evaluate drug therapy for alcohol dependence in the 12 months after first diagnosis in UK primary care. Design Open cohort study. Setting General practices contributing data to the UK Clinical Practice Research Database. Participants 39,980 people with an incident diagnosis of alcohol dependence aged 16 years or older between 1 January 1990 and 31 December 2013. Main...

Bullous Dermatosis in an End-Stage Renal Disease Patient: A Case Report and Literature Review

Patients with advanced chronic kidney disease including ESRD patients may present with a wide spectrum of cutaneous abnormalities, ranging from xerosis to hyperpigmentation to severe deforming necrotizing lesions. Skin problems are not uncommon in this population of patients, with a clinical presentation that can be quite bizarre, mandating a long list of differential diagnostic...

Bullous Dermatosis in an End-Stage Renal Disease Patient: A Case Report and Literature Review

Patients with advanced chronic kidney disease including ESRD patients may present with a wide spectrum of cutaneous abnormalities, ranging from xerosis to hyperpigmentation to severe deforming necrotizing lesions. Skin problems are not uncommon in this population of patients, with a clinical presentation that can be quite bizarre, mandating a long list of differential diagnostic...

Amorally Yours, A Letter from Dominique Strauss-Kahn to Marquis de Sade

With this paper, I satirically question how moral can a free market economy really be.

Cholesterol biosynthesis pathway as a novel mechanism of resistance to estrogen deprivation in estrogen receptor-positive breast cancer

Background Therapies targeting estrogenic stimulation in estrogen receptor-positive (ER+) breast cancer (BC) reduce mortality, but resistance remains a major clinical problem. Molecular studies have shown few high-frequency mutations to be associated with endocrine resistance. In contrast, expression profiling of primary ER+ BC samples has identified several promising signatures...

Extracellular excystation and development of Cryptosporidium: tracing the fate of oocysts within Pseudomonas aquatic biofilm systems

oocysts . Appl Environ Microbiol 1999 , 65 ( 9 ): 3936 - 3941 . 38. Edwards H , Andrew Thompson R , Koh WH , Clode PL : Labeling surface epitopes to identify Cryptosporidium life stages using a scanning

A review of factors influencing the stress response in Australian marsupials

Many Australian marsupials are threatened species. In order to manage in situ and ex situ populations effectively, it is important to understand how marsupials respond to threats. Stress physiology (the study of the response of animals to challenging stimuli), a key approach in conservation physiology, can be used to characterize the physiological response of wildlife to threats...

Susceptibility Weighted Imaging as a Useful Imaging Adjunct in Hemichorea Hyperglycaemia

Hyperglycaemia with hemichorea (HGHC) is an unusual clinical entity that can be associated with corpus striatum hyperintensity on T1-weighted (T1W) magnetic resonance imaging (MRI) sequences. We report the utility of the susceptibility weighted image (SWI) sequence and the filtered phase SWI sequence in the imaging assessment of HGHC.

RRP6 from Trypanosoma brucei: Crystal Structure of the Catalytic Domain, Association with EAP3 and Activity towards Structured and Non-Structured RNA Substrates

RRP6 is a 3′–5′ exoribonuclease associated to the eukaryotic exosome, a multiprotein complex essential for various RNA processing and degradation pathways. In Trypanosoma brucei, RRP6 associates with the exosome in stoichiometric amounts and was localized in both cytoplasm and nucleus, in contrast to yeast Rrp6 which is exclusively nuclear. Here we report the biochemical and...

Patient Experience Shows Little Relationship with Hospital Quality Management Strategies

Objectives Patient-reported experience measures are increasingly being used to routinely monitor the quality of care. With the increasing attention on such measures, hospital managers seek ways to systematically improve patient experience across hospital departments, in particular where outcomes are used for public reporting or reimbursement. However, it is currently unclear...

Simultaneous endovascular repair of an iatrogenic carotid-jugular fistula and a large iliocaval fistula presenting with multiorgan failure: a case report

Introduction Iliocaval fistulas can complicate an iliac artery aneurysm. The clinical presentation is classically a triad of hypotension, a pulsatile mass and heart failure. In this instance, following presentation with multiorgan failure, management included the immediate use of an endovascular stent graft on discovery of the fistula. Case presentation A 62-year-old Caucasian...

Is there a gap between recommended and ‘real world’ practice in the management of depression in young people? A medical file audit of practice

BackgroundLiterature has shown that dissemination of guidelines alone is insufficient to ensure that guideline recommendations are incorporated into every day clinical practice.MethodsWe aimed to investigate the gaps between guideline recommendations and clinical practice in the management of young people with depression by undertaking an audit of medical files in a catchment...

Predictive testing for inherited prion disease: report of 22 years experience

, Tracy Campbell, Gary Adamson, Andrew Thompson, John Collinge & Simon MeadClinical Genetics, St Michael’s Hospital, Bristol, UKSarah SmithsonClinical Genetics, Great Ormond St Hospital, London, UKElizabeth ... research. Author information AffiliationsNHS National Prion Clinic, National Hospital for Neurology and Neurosurgery, University College Hospitals NHS Trust, London, UKJane Owen, Michele Gorham, Andrew