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Why We Still Need To Speak About Sex Differences and Sex Hormones in Pain

for the integrity of the work as a whole, and has given final approval for the version to be published. Disclosures. Anna Maria Aloisi has nothing to disclose. Compliance with Ethics Guidelines. This

In Vitro and In Vivo Characterization of the New Analgesic Combination Beta-Caryophyllene and Docosahexaenoic Acid

Beta-caryophyllene (BCP) and docosahexaenoic acid (DHA) are components of several plants with documented anti-inflammatory and analgesic effects in animal pain models. In the present study, in vitro and in vivo tests were carried out to evaluate their effects, alone or in combination, during long-lasting administration in a model of persistent pain. IR spectra of the two...

Testosterone-Induced Effects on Lipids and Inflammation

Chronic pain has to be considered in all respects a debilitating disease and 10–20% of the world's adult population is affected by this disease. In the most general terms, pain is symptomatic of some form of dysfunction and (often) the resulting inflammatory processes in the body. In the study of pain, great attention has been paid to the possible involvement of gonadal hormones...

Inflammatory Pain and Corticosterone Response in Infant Rats: Effect of 5-HT1A Agonist Buspirone Prior to Gestational Stress

. Vershinina,3 Anna Maria Aloisi,4 and Vladimir A. Otellin1 1Laboratory of Ontogeny of the Nervous System, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, Nab. Makarova 6, St. Petersburg