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How to responsibly acknowledge research work in the era of big data and biobanks: ethical aspects of the Bioresource Research Impact Factor (BRIF)

Currently, a great deal of biomedical research in fields such as epidemiology, clinical trials and genetics is reliant on vast amounts of biological and phenotypic information collected and assembled in biobanks. While many resources are being invested to ensure that comprehensive and well-organised biobanks are able to provide increased access to, and sharing of biomedical samples ...

Developing a guideline to standardize the citation of bioresources in journal articles (CoBRA)

Background Many biomedical publications refer to data obtained from collections of biosamples. Sharing such bioresources (biological samples, data, and databases) is paramount for the present governance of research. Recognition of the effort involved in generating, maintaining, and sharing high quality bioresources is poorly organized, which does not encourage sharing. At ...

Mapping the translational science policy ‘valley of death’

Region he is also conducting research on the ethical and regulatory aspects of the governance of stem cell-based medicine. Anne Cambon-Thomsen, MD, is Director of Research in CNRS (French national centre

Linkage disequilibrium organization of the human KIR superlocus: implications for KIR data analyses

analytical strategy. Anne Cambon- Thomsen contributed to the discussion and the manuscript. Derek Middleton and Pierre-Antoine Gourraud conceived the research and wrote the paper 1 ) Department of Neurology

New classification of HLA-DRB1 alleles in rheumatoid arthritis susceptibility: a combined analysis of worldwide samples

Introduction Rheumatoid arthritis (RA) is a complex polygenic disease of unknown etiology. HLA-DRB1 alleles encoding the shared epitope (SE) (RAA amino acid pattern in positions 72 to 74 of the third hypervariable region of the DRβ1 chain) are associated with RA susceptibility. A new classification of HLA-DRB1 SE alleles has been developed by Tezenas du Montcel and colleagues to ...

Public Health Genomics (PHG) and Public Participation: Points to Consider

:// Authors Denise Avard, Lucie M. Bucci, Michael M. Burgess, Jane Kaye, Catherine Heeney, Yanick Farmer, and Anne Cambon-Thomsen This contributions is available in Journal of Public Deliberation

A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for autoantibody production in rheumatoid arthritis

The HLA-DRB1 gene was reported to be associated with anticitrullinated protein/peptide autoantibody (ACPA) production in rheumatoid arthritis (RA) patients. A new classification of HLA-DRB1 alleles, reshaping the shared epitope (SE) hypothesis, was recently found relevant in terms of RA susceptibility and structural severity. We investigated the relevance of this new classification ...

Biobanking for Europe

Biobanks are well-organized resources comprising biological samples and associated information that are accessible to scientific investigation. Across Europe, millions of samples with related data are held in different types of collections. While individual collections can be well organized and accessible, the resources are subject to fragmentation, insecurity of funding and ...

Systems medicine and integrated care to combat chronic noncommunicable diseases

Brightling Anne Cambon-Thomsen Alfredo Cesario Sonia Abdelhak Stylianos E Antonarakis Antoine Avignon Andrea Ballabio Eugenio Baraldi Alexander Baranov Thomas Bieber Joël Bockaert Samir Brahmachari Christian