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Computational study of HIV gp120 as a target for polyanionic entry inhibitors: Exploiting the V3 loop region

. Hollingsworth, IV, Anne M. Brown, Richard D. Gandour, David R. Bevan. Data curation: Louis R. Hollingsworth, IV. Formal analysis: Anne M. Brown, Richard D. Gandour, David R. Bevan. Investigation: Louis R ... . Hollingsworth, IV, Anne M. Brown, David R. Bevan. Methodology: Louis R. Hollingsworth, IV, Anne M. Brown, Richard D. Gandour, David R. Bevan. Project administration: Anne M. Brown, David R. Bevan. Supervision

Purine biosynthesis in archaea: variations on a theme

Background The ability to perform de novo biosynthesis of purines is present in organisms in all three domains of life, reflecting the essentiality of these molecules to life. Although the pathway is quite similar in eukaryotes and bacteria, the archaeal pathway is more variable. A careful manual curation of genes in this pathway demonstrates the value of manual curation in...