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Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype

) Acknowledgments The technical assistance by Petra Lippmann is acknowledged. Conceptualization: Anne Walter, Stefan Knapp, Laurent Meijer, Conrad Kunick. Data curation: Anne Walter, Apirat Chaikuad, Renate Helmer ... , Nadège LoaeÈc, Ingo Ott, Stefan Knapp, Laurent Meijer, Conrad Kunick. Formal analysis: Anne Walter, Apirat Chaikuad, Nadège LoaeÈc, Lutz Preu, Ingo Ott, Laurent Meijer, Conrad Kunick. Funding

The Closely Related CD103+ Dendritic Cells (DCs) and Lymphoid-Resident CD8+ DCs Differ in Their Inflammatory Functions

Migratory CD103+ and lymphoid-resident CD8+ dendritic cells (DCs) share many attributes, such as dependence on the same transcription factors, cross-presenting ability and expression of certain surface molecules, such that it has been proposed they belong to a common sub-lineage. The functional diversity of the two DC types is nevertheless incompletely understood. Here we reveal...

Spatial organization of a ubiquitous eukaryotic kinetochore protein network in Drosophila chromosomes

Chromosome segregation during meiosis and mitosis depends on the assembly of functional kinetochores within centromeric regions. Centromeric DNA and kinetochore proteins show surprisingly little sequence conservation despite their fundamental biological role. However, our identification in Drosophila melanogaster of the most diverged orthologs identified so far, which encode...