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6 papers found.
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Cardiovascular risk in patients with alpha-1-antitrypsin deficiency

Alpha-1-antitrypsin deficiency (AATD) is a rare inherited condition caused by mutations of the SERPINA1 gene that is associated with the development of a COPD like lung disease. The comorbidities in patients with AATD-related lung diseases are not well defined. The aim of this study was to analyze the clinical phenotype of AATD patients within the German COPD cohort study COSYCONET ...

A phase II trial comparing pazopanib with doxorubicin as first-line treatment in elderly patients with metastatic or advanced soft tissue sarcoma (EPAZ): study protocol for a randomized controlled trial

randomized controlled trial Annika Karch 1 Armin Koch 1 Viktor Grünwald 0 0 Clinic for Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School , Carl-Neuberg-Strasse 1, 30625

ACEMg-mediated hearing preservation in cochlear implant patients receiving different electrode lengths (PROHEARING): study protocol for a randomized controlled trial

Background The indications for a cochlear implant (CI) have been extended to include patients with some residual hearing. Shorter and thinner atraumatic electrodes have been designed to preserve the residual hearing in the implanted ear. However, the insertion of the electrode array into the cochlea, with potential mechanical trauma and the presence of this foreign body inside the ...

Relative impact of COPD and comorbidities on generic health-related quality of life: a pooled analysis of the COSYCONET patient cohort and control subjects from the KORA and SHIP studies

KORA and SHIP studies Margarethe E. Wacker 0 Rudolf A. Jörres Annika Karch Armin Koch Joachim Heinrich Stefan Karrasch Holger Schulz Annette Peters Sven Gläser Ralf Ewert Sebastian E. Baumeister Claus

Assessing health-related quality of life in COPD: comparing generic and disease-specific instruments with focus on comorbidities

Background Chronic Obstructive Pulmonary Disease (COPD) influences different aspects of patient’s health-related quality of life (HRQL). While disease-specific HRQL instruments focus on symptoms and functional impairments, generic instruments cover a broader view on health. This study compares the generic EQ-5D-3 L and two disease-specific questionnaires (St.-George’s Respiratory ...

Non-invasive diagnosis of acute rejection in renal transplant patients using mass spectrometry of urine samples - a multicentre phase 3 diagnostic accuracy study

Gwinner 0 Annika Karch Jochen Metzger Hermann Haller Armin Koch 0 Equal contributors 1 Institute for Medical Statistics, University Medical Center Göttingen , Humboldtallee 32, 37073 Göttingen , Germany