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Association between urinary free light chains and progression to end stage renal disease in chronic kidney disease

research fellowship. Author Contributions Conceptualization: Iain Chapple, Indranil Dasgupta, Stephen J. Harding, Charles J. Ferro, Paul Cockwell. Data curation: Anthony Fenton, Mark D. Jesky, Rachel ... Webster, Stephanie J. Stringer, Punit Yadav, Indranil Dasgupta, Stephen J. Harding, Charles J. Ferro, Paul Cockwell. Formal analysis: Anthony Fenton. Funding acquisition: Stephen J. Harding, Charles J

Serum endotrophin, a type VI collagen cleavage product, is associated with increased mortality in chronic kidney disease

Background Patients with chronic kidney disease (CKD) are at increased risk of end-stage renal disease (ESRD) and early mortality. The underlying pathophysiological processes are not entirely understood but may include dysregulation of extracellular matrix formation with accelerated systemic and renal fibrosis. We assessed the relationship between endotrophin (ETP), a marker of...

Health-Related Quality of Life Impacts Mortality but Not Progression to End-Stage Renal Disease in Pre-Dialysis Chronic Kidney Disease: A Prospective Observational Study

Background Chronic kidney disease (CKD) is associated with reduced health-related quality of life (HRQL). However, the relationship between pre-dialysis CKD, HRQL and clinical outcomes, including mortality and progression to end-stage renal disease (ESRD) is unclear. Methods All 745 participants recruited into the Renal Impairment In Secondary Care study to end March 2014 were...