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Global, Regional, and National Estimates of Rotavirus Mortality in Children <5 Years of Age, 2000–2013

Background. Rotavirus vaccine is recommended for routine use in all countries globally. To facilitate decision making on rotavirus vaccine adoption by countries, help donors prioritize investments in health interventions, and monitor vaccine impact, we estimated rotavirus mortality for children <5 years of age from 2000 to 2013. Methods. We searched PubMed using the keyword...

Intestinal Immunity Is a Determinant of Clearance of Poliovirus After Oral Vaccination

. Boesch 6 Margaret E. Ackerman 6 Harrie van der Avoort 5 M. Steven Oberste 4 Mark A. Pallansch 4 Anthony H. Burton 3 Mohammad A. Jaffar 8 Roland W. Sutter 7 0 National Institute of Infectious Disease

Randomized Trial of Type 1 and Type 3 Oral Monovalent Poliovirus Vaccines in Newborns in Africa

(See the editorial commentary by Cochi and Linkins, on pages 169–71.) ARTICLE Background. The Global Polio Eradication Initiative aims to eradicate wild poliovirus by the end of 2012. Therefore, more-immunogenic polio vaccines, including monovalent oral poliovirus vaccines (mOPVs), are needed for supplemental immunization activities. This trial assessed the immunogenicity of...