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Search: authors:"Antje R. Weseler"

5 papers found.
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Redox-dependent thiol modifications: implications for the release of extracellular vesicles

Extracellular vesicles (EVs), including microvesicles and exosomes, are emerging as important regulators of homeostasis and pathophysiology. During pro-inflammatory and pro-oxidant conditions, EV release is induced. As EVs released under such conditions often exert pro-inflammatory and procoagulant effects, they may actively promote the pathogenesis of chronic diseases. There is...

Protection against Chemotaxis in the Anti-Inflammatory Effect of Bioactives from Tomato Ketchup

Guido R. M. M. Haenen * 0 Antje R. Weseler 0 Aalt Bast 0 0 Department of Toxicology, Faculty of Health, Medicine and Life Sciences, Maastricht University , Maastricht , The Netherlands - The

Oxidative Stress and Vascular Function: Implications for Pharmacologic Treatments

Antje R. Weseler Aalt Bast 0 ) Department of Pharmacology and Toxicology, Maastricht University Medical Centre, Universiteitssingel 50 , 6229 ER Maastricht, The Netherlands Production of

Dietary Flavanols Modulate the Transcription of Genes Associated with Cardiovascular Pathology without Changes in Their DNA Methylation State

Background In a recent intervention study, the daily supplementation with 200 mg monomeric and oligomeric flavanols (MOF) from grape seeds for 8 weeks revealed a vascular health benefit in male smokers. The objective of the present study was to determine the impact of MOF consumption on the gene expression profile of leukocytes and to assess changes in DNA methylation...

Pleiotropic Benefit of Monomeric and Oligomeric Flavanols on Vascular Health - A Randomized Controlled Clinical Pilot Study

Background Cardiovascular diseases are expanding to a major social-economic burden in the Western World and undermine man's deep desire for healthy ageing. Epidemiological studies suggest that flavanol-rich foods (e.g. grapes, wine, chocolate) sustain cardiovascular health. For an evidenced-based application, however, sound clinical data on their efficacy are strongly demanded...