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Double-edged sword of gonadotropin-releasing hormone (GnRH): A novel role of GnRH in the multiple beneficial functions of endometrial stem cells

supported by a fund (HD18A0016) by Research of Korea Centers for Disease Control and Prevention. Author information Author notes These authors contribute equally: Se-Ra Park, Ara Cho AffiliationsDepartment ... of Health Sciences and Technology, GAIHST, Gachon University, Incheon, 21999, Republic of KoreaSe-Ra Park, Ara Cho & In-Sun HongDepartment of Molecular Medicine, School of Medicine, Gachon University

MUFFINN: cancer gene discovery via network analysis of somatic mutation data

A major challenge for distinguishing cancer-causing driver mutations from inconsequential passenger mutations is the long-tail of infrequently mutated genes in cancer genomes. Here, we present and evaluate a method for prioritizing cancer genes accounting not only for mutations in individual genes but also in their neighbors in functional networks, MUFFINN (MUtations For...

WormNet v3: a network-assisted hypothesis-generating server for Caenorhabditis elegans

High-throughput experimental technologies gradually shift the paradigm of biological research from hypothesis-validation toward hypothesis-generation science. Translating diverse types of large-scale experimental data into testable hypotheses, however, remains a daunting task. We previously demonstrated that heterogeneous genomics data can be integrated into a single genome-scale...

FlyNet: a versatile network prioritization server for the Drosophila community

Drosophila melanogaster (fruit fly) has been a popular model organism in animal genetics due to the high accessibility of reverse-genetics tools. In addition, the close relationship between the Drosophila and human genomes rationalizes the use of Drosophila as an invertebrate model for human neurobiology and disease research. A platform technology for predicting candidate genes...