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Chloral hydrate enteral infusion for sedation in ventilated children: the CHOSEN pilot study

We aimed to test a novel method of delivery of chloral hydrate (CH) sedation in ventilated critically ill young children. Children < 12 years old, within 72 hours of admission, who were ventilated, receiving enteral tube-feeds, with intermittent CH ordered were enrolled after signed consent. Patients received a CH loading-dose of 10 mg/kg enterally, then a syringe-pump enteral ...

Publication bias in animal research presented at the 2008 Society of Critical Care Medicine Conference

Background To determine a direct measure of publication bias by determining subsequent full-paper publication (P) of studies reported in animal research abstracts presented at an international conference (A). Methods We selected 100 random (using a random-number generator) A from the 2008 Society of Critical Care Medicine Conference. Using a data collection form and study manual, ...

The methodological quality of animal research in critical care: the public face of science

Meredith Bara 1 Ari R Joffe 0 0 Department of Pediatrics, 4-546 Edmonton Clinic Health Academy, University of Alberta , 11405 87 Avenue, Edmonton , Alberta T6G 1C9, Canada 1 Faculty of Medicine and

The ethical dimension in published animal research in critical care: the public face of science

Introduction The ethical quality of animal research is important for many reasons, including for maintaining public support. We aimed to determine the reported attention to the ethical dimensions of the 3Rs (Refinement, Reduction, and Replacement) in critical care animal research published in 2012. Methods A data-collection form and instruction manual were created based on ...

Early childhood language outcomes after arterial switch operation: a prospective cohort study

Background Developmental and language outcomes at 2 years of age of children who had arterial switch operation (ASO) for transposition of the great arteries 2004–2010 are described. Methods In this prospective cohort study, 91/98 (93 %) children who underwent ASO were assessed at 2 years of age with the Bayley Scales of Infant risk factors for this in multivariate analyses ...

A simple meningococcal sepsis prognostic score: focusing on the human animal

A simple cheap meningococcal sepsis prognostic score based on readily available, rapid, objective laboratory base excess and platelet count was developed and validated retrospectively. This BEP score should facilitate sepsis clinical trials, allowing study of the relevant human animal model.

Diagnostic accuracy of delirium diagnosis in pediatric intensive care: a systematic review

Introduction Delirium is common in adult intensive care, with validated tools for measurement, known risk factors and adverse neurocognitive outcomes. We aimed to determine what is known about pediatric delirium in the pediatric intensive care unit (PICU). Methods We conducted a systematic search for and review of studies of the accuracy of delirium diagnosis in children in the ...

Variability in the pediatric intensivists' threshold for withdrawal/limitation of life support as perceived by bedside nurses: a multicenter survey study

Colleen S Gresiuk 0 Ari R Joffe 0 0 University of Alberta, Stollery Children's Hospital , 8440 112 Street, Edmonton , Alberta, T6G 2B7, Canada Background: We hypothesized that bedside nurses

A survey of American neurologists about brain death: understanding the conceptual basis and diagnostic tests for brain death

Background Neurologists often diagnose brain death (BD) and explain BD to families in the intensive care unit. This study was designed to determine whether neurologists agree with the standard concept of death (irreversible loss of integrative unity of the organism) and understand the state of the brain when BD is diagnosed. Methods A previously validated survey was mailed to a ...

Multicentre validation of the bedside paediatric early warning system score: a severity of illness score to detect evolving critical illness in hospitalised children

Introduction The timely provision of critical care to hospitalised patients at risk for cardiopulmonary arrest is contingent upon identification and referral by frontline providers. Current approaches require improvement. In a single-centre study, we developed the Bedside Paediatric Early Warning System (Bedside PEWS) score to identify patients at risk. The objective of this study ...