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Dietary and health biomarkers—time for an update

In the dietary and health research area, biomarkers are extensively used for multiple purposes. These include biomarkers of dietary intake and nutrient status, biomarkers used to measure the biological effects of specific dietary components, and biomarkers to assess the effects of diet on health. The implementation of biomarkers in nutritional research will be important to...

Guidelines for Biomarker of Food Intake Reviews (BFIRev): how to conduct an extensive literature search for biomarker of food intake discovery

Gao 0 Augustin Scalbert 2 Guy Vergères 1 Marjukka Kolehmainen 7 Claudine Manach 6 Lorraine Brennan 5 Sri Harsha Pedapati 5 Lydia A. Afman 4 David S. Wishart 9 Rosa Vázquez-Fresno 9 Cristina Andres

A scheme for a flexible classification of dietary and health biomarkers

Biomarkers are an efficient means to examine intakes or exposures and their biological effects and to assess system susceptibility. Aided by novel profiling technologies, the biomarker research field is undergoing rapid development and new putative biomarkers are continuously emerging in the scientific literature. However, the existing concepts for classification of biomarkers in...

Exposome-Explorer: a manually-curated database on biomarkers of exposure to dietary and environmental factors

Exposome-Explorer ( is the first database dedicated to biomarkers of exposure to environmental risk factors. It contains detailed information on the nature of biomarkers, their concentrations in various human biospecimens, the study population where measured and the analytical techniques used for measurement. It also contains correlations with...

MetMSLine: an automated and fully integrated pipeline for rapid processing of high-resolution LC–MS metabolomic datasets

Summary: MetMSLine represents a complete collection of functions in the R programming language as an accessible GUI for biomarker discovery in large-scale liquid-chromatography high-resolution mass spectral datasets from acquisition through to final metabolite identification forming a backend to output from any peak-picking software such as XCMS. MetMSLine automatically creates...

Reliability of Serum Metabolites over a Two-Year Period: A Targeted Metabolomic Approach in Fasting and Non-Fasting Samples from EPIC

Objective Although metabolic profiles have been associated with chronic disease risk, lack of temporal stability of metabolite levels could limit their use in epidemiological investigations. The present study aims to evaluate the reliability over a two-year period of 158 metabolites and compare reliability over time in fasting and non-fasting serum samples. Methods Metabolites...

Modulation of miRNA Expression by Dietary Polyphenols in apoE Deficient Mice: A New Mechanism of the Action of Polyphenols

Background Polyphenols are the most abundant antioxidants in the human diet and are widespread constituents of fruits and beverages, such as tea, coffee or wine. Epidemiological, clinical and animal studies support a role of polyphenols in the prevention of various diseases, such as cardiovascular diseases, cancers or neurodegenerative diseases. Recent findings suggest that...

Phenol-Explorer 3.0: a major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content

Clermont-Ferrand , France 2 Present address: Augustin Scalbert, International Agency for Research on Cancer (IARC) , Lyon , France 3 International Agency for Research on Cancer (IARC), Nutrition and

Assessment of dietary intake: NuGO symposium report

. Food chemistry, xenobiotic metabolism and dietary assessment: bioinformatics and metabolomics to decipher their complex links Augustin Scalbert (Unite de Nutrition Humaine, INRA, France) introduced ... illustrate the data-driven approach, Augustin Scalbert described a proof-of-principle metabolomics study that was carried out in his laboratory to identify markers of consumption of citrus fruit juices. Urine

Phenol-Explorer 2.0: a major update of the Phenol-Explorer database integrating data on polyphenol metabolism and pharmacokinetics in humans and experimental animals

-Lacueva 4 6 Augustin Scalbert 2 7 0 CIBER 08/08: Fisiopatologa de la Obesidad y la Nutricio n and RD06/0045/1003 Alimentaci on Saludable, Instituto de Salud Carlos III , Spain 1 Department of Internal

Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research

Mass spectrometry (MS) techniques, because of their sensitivity and selectivity, have become methods of choice to characterize the human metabolome and MS-based metabolomics is increasingly used to characterize the complex metabolic effects of nutrients or foods. However progress is still hampered by many unsolved problems and most notably the lack of well established and...

HMDB 3.0—The Human Metabolome Database in 2013

The Human Metabolome Database (HMDB) ( is a resource dedicated to providing scientists with the most current and comprehensive coverage of the human metabolome. Since its first release in 2007, the HMDB has been used to facilitate research for nearly 1000 published studies in metabolomics, clinical biochemistry and systems biology. The most recent release of HMDB...

Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort

Background Hepatocellular carcinoma (HCC), the most prevalent form of liver cancer, is difficult to diagnose and has limited treatment options with a low survival rate. Aside from a few key risk factors, such as hepatitis, high alcohol consumption, smoking, obesity, and diabetes, there is incomplete etiologic understanding of the disease and little progress in identification of...

Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study

Background Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and...

Challenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies

The challenge of modern nutrition and health research is to identify food-based strategies promoting life-long optimal health and well-being. This research is complex because it exploits a multitude of bioactive compounds acting on an extensive network of interacting processes. Whereas nutrition research can profit enormously from the revolution in ‘omics’ technologies, it has...

Thyroid-Stimulating Hormone, Thyroglobulin, and Thyroid Hormones and Risk of Differentiated Thyroid Carcinoma: The EPIC Study

. Travis Graham Byrnes Augustin Scalbert Isabelle Romieu Marc Gunter Elio Riboli Silvia Franceschi Increased levels of thyroglobulin (Tg) and thyroid-stimulating hormone (TSH) are associated with

The Association Between Dietary Flavonoid and Lignan Intakes and Incident Type 2 Diabetes in European Populations: The EPIC-InterAct study

OBJECTIVE To study the association between dietary flavonoid and lignan intakes, and the risk of development of type 2 diabetes among European populations.

Dietary Flavonoid Intake and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Cohort

, University Medical Center Utrecht, Utrecht, the Netherlands (H. Bas Bueno-de-Mesquita, Peter D. Siersema); Nutrition and Metabolism Section, International Agency for Research on Cancer, Lyon, France (Augustin ... Scalbert, Isabelle Romieu, Veronika Fedirko); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia (Veronica Fedirko); Institut National de la Santé et de la