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Nestin-expressing progenitor cells: function, identity and therapeutic implications

The neuroepithelial stem cell protein, or Nestin, is a cytoskeletal intermediate filament initially characterized in neural stem cells. However, current extensive evidence obtained in in vivo models and humans shows presence of Nestin+ cells with progenitor and/or regulatory functions in a number of additional tissues, remarkably bone marrow. This review presents the current...

Membrane Blebbing Is Required for Mesenchymal Precursor Migration

Mesenchymal precursors (MPs) present some advantageous features, such as differentiation and migration, which make them promising candidates for cell therapy. A better understanding of MP migration characteristics would aid the development of cell delivery protocols. Traditionally, cell migration is thought to occur only through the formation of lamellipodia. More recently...

The Potential of Stem Cells in the Treatment of Cardiovascular Diseases

Aurora Bernal Beatriz G. Glvez Clinical Imperative 0 ) Centro Nacional de Investigaciones Cardiovasculares (CNIC) , C/Melchor Fernndez Almagro, 3, 28029 Madrid, Spain Although the adult mammalian

Altered Metabolic and Stemness Capacity of Adipose Tissue-Derived Stem Cells from Obese Mouse and Human

Adipose stem cells (ASCs) are an appealing source of cells for therapeutic intervention; however, the environment from which ASCs are isolated may impact their usefulness. Using a range of functional assays, we have evaluated whether ASCs isolated from an obese environment are comparable to cells from non-obese adipose tissue. Results showed that ASCs isolated from obese tissue...

Metabolic Rescue of Obese Adipose-Derived Stem Cells by Lin28/Let7 Pathway

Laura M. Prez Aurora Bernal Nuria San Martn Margarita Lorenzo Sonia Fernndez-Veledo Beatriz G. Glvez Adipose-derived stem cells (ASCs) are promising candidates for autologous cell-based regeneration

Method for Obtaining Committed Adult Mesenchymal Precursors from Skin and Lung Tissue

Aims The present study reports an easy and efficient method for obtaining adult mesenchymal precursors from different adult mouse tissues. Materials and Methods We describe the isolation and expansion of mesenchymal precursors from skin and lung by a non-enzymatic method. Skin and lung mesenchymal precursors isolated by a modified explant technique were characterized in vitro by...