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Neuropsychology and Advances in Memory Function

Neuropsychology and advances in memory function B. Gordon 0 0 Departments of Neurology and Cognitive Science, The Johns Hopkins University, Cognitive Neurology/Neuropsychology and The Memory Clinic

Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype

Hutchinson-Gilford syndrome (HGPS, OMIM 176670, a rare premature aging disorder that leads to death at an average age of 14.7 years due to myocardial infarction or stroke, is caused by mutations in the LMNA gene. Lamins help maintain the shape and stability of the nuclear envelope in addition to regulating DNA replication, DNA transcription, proliferation and differentiation. The...

Fluoride export (FEX) proteins from fungi, plants and animals are 'single barreled' channels containing one functional and one vestigial ion pore

The fluoride export protein (FEX) in yeast and other fungi provides tolerance to fluoride (F-), an environmentally ubiquitous anion. FEX efficiently eliminates intracellular fluoride that otherwise would accumulate at toxic concentrations. The FEX homolog in bacteria, Fluc, is a ‘double-barreled’ channel formed by dimerization of two identical or similar subunits. FEX in yeast...

American Society for Enhanced Recovery (ASER) and Perioperative Quality Initiative (POQI) Joint Consensus Statement on Optimal Analgesia within an Enhanced Recovery Pathway for Colorectal Surgery: Part 2—From PACU to the Transition Home

Background Within an enhanced recovery pathway (ERP), the approach to treating pain should be multifaceted and the goal should be to deliver “optimal analgesia”, which we define in this paper as a technique that optimizes patient comfort and facilitates functional recovery with the fewest medication side effects. Methods With input from a multidisciplinary, international group of...

Bringing Eyes of Faith to Film: Using Popular Movies to Cultivate a Sacramental Imagination and Improve Media Literacy in Adolescents

Loyola Marymount University and Loyola Law School. For more information about Digital Commons , please contact 1 Charles B. Gordon, C.S.C. Karen E. Eifler University of Portland , Oregon , USA - Bringing

Minimum Incidence of Adult Invasive Pneumococcal Disease in Blantyre, Malawi an Urban African Setting: A Hospital Based Prospective Cohort Study

Invasive pneumococcal disease causes substantial morbidity and mortality in Africa. Evaluating population level indirect impact on adult disease of pneumococcal conjugate vaccine (PCV) programmes in infants requires baseline population incidence rates but these are often lacking in areas with limited disease surveillance. We used hospital based blood culture and cerebrospinal...

Chronic Household Air Pollution Exposure Is Associated with Impaired Alveolar Macrophage Function in Malawian Non-Smokers

Background Household air pollution in low income countries is an important cause of mortality from respiratory infection. We hypothesised that chronic smoke exposure is detrimental to alveolar macrophage function, causing failure of innate immunity. We report the relationship between macrophage function and prior smoke exposure in healthy Malawians. Methods Healthy subjects...

Novel Analysis of Immune Cells from Nasal Microbiopsy Demonstrates Reliable, Reproducible Data for Immune Populations, and Superior Cytokine Detection Compared to Nasal Wash

The morbidity and mortality related to respiratory tract diseases is enormous, with hundreds of millions of individuals afflicted and four million people dying each year. Understanding the immunological processes in the mucosa that govern outcome following pathogenic encounter could lead to novel therapies. There is a need to study responses at mucosal surfaces in humans for two...

Application of Au–Cu nanowires fabricated by laser ablation in superfluid helium as catalysts for CO oxidation

, Moscow, Russian Federation 115409 1 Institute of Problems of Chemical Physics RAS , 1 Semenov avenue, Chernogolovka, Moscow Region, Russian Federation 142432 2 E. B. Gordon 3 Lomonosov Moscow State ... superfluid helium . Appl Phys Lett 101 : 052605 ( 1 )- 052605 ( 5 ) 27. Lebedev V , Moroshkin P , Grobety B , Gordon E , Weis A ( 2011 ) Formation of metallic nanowires by laser ablation in liquid helium . J

Oral Typhoid Vaccination With Live-Attenuated Salmonella Typhi Strain Ty21a Generates Ty21a-Responsive and Heterologous Influenza Virus–Responsive CD4+ and CD8+ T Cells at the Human Intestinal Mucosa

Background. Oral vaccination with live-attenuated Salmonella Typhi strain Ty21a is modestly efficacious, but the mechanisms of protection are currently unknown. While humoral and cellular immune responses are well described in peripheral blood, the cellular response at the intestinal mucosa has never been directly assessed. Methods. We vaccinated healthy adults with Ty21a and...

Cardiovascular imaging in children and adults following Kawasaki disease

Kawasaki disease (KD) is a paediatric vasculitis with coronary artery aneurysms (CAA) as its main complication. Two guidelines exist regarding the follow-up of patients after KD, by the American Heart Association and the Japanese Circulation Society. After the acute phase, CAA-negative patients are checked for cardiovascular risk assessment or with ECG and echocardiography until...

Ustekinumab: an evidence-based review of its effectiveness in the treatment of psoriasis

Ustekinumab: an evidence-based review of its effectiveness in the treatment of psoriasis Eliana Krulig, Kenneth B GordonNorthShore University HealthSystem, University of Chicago, Pritzker School of Medicine, Skokie, IL, USAIntroduction: Psoriasis is a chronic inflammatory skin disease affecting approximately 2% to 3% of the population worldwide. Discoveries over the past 3 to 5...

Feasibility study for early supported discharge in adults with respiratory infection in the UK

Background Many patients with pneumonia and lower respiratory tract infection that could be treated as outpatients according to their clinical severity score, are in fact admitted to hospital. We investigated whether, with medical and social input, these patients could be discharged early and treated at home. Objectives: (1) To assess the feasibility of providing an early...

Identification of novel non-canonical RNA-binding sites in Gemin5 involved in internal initiation of translation

Ribonucleic acid (RNA)-binding proteins are key players of gene expression control. We have shown that Gemin5 interacts with internal ribosome entry site (IRES) elements and modulates initiation of translation. However, little is known about the RNA-binding sites of this protein. Here we show that the C-terminal region of Gemin5 bears two non-canonical bipartite RNA-binding sites...

Lanreotide extended-release aqueous-gel formulation, injected by patient, partner or healthcare provider in patients with acromegaly in the United States: 1-year data from the SODA registry

Endocrinology, Ipsen Biopharmaceuticals , Inc, Basking Ridge, NJ, USA 5 M. B. Gordon Allegheny Neuroendocrinology Center, Division of Endocrinology, Allegheny General Hospital , Pittsburgh, PA, USA Lanreotide

Incomplete Recovery of Pneumococcal CD4 T Cell Immunity after Initiation of Antiretroviral Therapy in HIV-Infected Malawian Adults

HIV-infected African adults are at a considerably increased risk of life-threatening invasive pneumococcal disease (IPD) which persists despite antiretroviral therapy (ART). Defects in naturally acquired pneumococcal-specific T-cell immunity have been identified in HIV-infected adults. We have therefore determined the extent and nature of pneumococcal antigen-specific immune...

Impact of Experimental Human Pneumococcal Carriage on Nasopharyngeal Bacterial Densities in Healthy Adults

Colonization of the nasopharynx by Streptococcus pneumoniae is a necessary precursor to pneumococcal diseases that result in morbidity and mortality worldwide. The nasopharynx is also host to other bacterial species, including the common pathogens Staphylococcus aureus, Haemophilus influenzae, and Moraxella catarrhalis. To better understand how these bacteria change in relation...

Relationship of Metabolism and Cell Proliferation to the Mode of Action of Fluensulfone-Induced Mouse Lung Tumors: Analysis of Their Human Relevance Using the IPCS Framework

Christian Strupp 2 Deborah A. Banas 0 Samuel M. Cohen 1 Elliot B. Gordon 4 Martina Jaeger 3 Klaus Weberk To whom correspondence should be addressed at Makhteshim Agan Holding B.V. Schaffhausen Branch