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Synthesis, characterization, biological evaluation and molecular docking studies of 2-(1H-benzo[d]imidazol-2-ylthio)-N-(substituted 4-oxothiazolidin-3-yl) acetamides

Background A series of 2-(1H-benzo[d]imidazol-2-ylthio)-N-(substituted 4-oxothiazolidin-3-yl) acetamides was synthesized and characterized by physicochemical and spectral means. The synthesized compounds were evaluated for their in vitro antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Candida albicans and Aspergillus niger by tube...

Bis-pyrimidine acetamides: design, synthesis and biological evaluation

Background In the past few years, increased resistance of microorganisms towards antimicrobial agents become a serious health problem, so there is a need for the discovery of new antimicrobial agents. On the other hand, bis-pyrimidines possess various types of biological activity. In view of this, in the present study we have designed and synthesized a new series of bis...

Synthesis, molecular docking and biological evaluation of bis-pyrimidine Schiff base derivatives

Vasudevan Syed Adnan Ali Shah Manikandan Selvaraj Balasubramanian Narasimhan 0 0 Faculty of Pharmaceutical Sciences, Maharshi Dayanand University , Rohtak 124001 , India Background: Heterocyclic pyrimidine

Variability in CRP, regulatory T cells and effector T cells over time in gynaecological cancer patients: a study of potential oscillatory behaviour and correlations

Mutsa T Madondo 0 Sandra Tuyaerts Brit B Turnbull Anke Vanderstraeten Holbrook Kohrt Balasubramanian Narasimhan Frederic Amant Michael Quinn Magdalena Plebanski 0 1 0 Department of Immunology, Vaccine

A method for calling gains and losses in array CGH data

Array CGH is a powerful technique for genomic studies of cancer. It enables one to carry out genome-wide screening for regions of genetic alterations, such as chromosome gains and losses, or localized amplifications and deletions. In this paper, we propose a new algorithm ‘Cluster along chromosomes’ (CLAC) for the analysis of array CGH data. CLAC builds hierarchical clustering...

Sample classification from protein mass spectrometry, by ‘peak probability contrasts’

Motivation: Early cancer detection has always been a major research focus in solid tumor oncology. Early tumor detection can theoretically result in lower stage tumors, more treatable diseases and ultimately higher cure rates with less treatment-related morbidities. Protein mass spectrometry is a potentially powerful tool for early cancer detection. We propose a novel method for...

Characterizing the admixed African ancestry of African Americans

L Assimes 5 Alan S Go 4 Mark A Hlatky Carlos Iribarren 4 Joshua W Knowles 5 Jun Li 1 Balasubramanian Narasimhan Steven Sidney 4 Audrey Southwick 3 Richard M Myers 2 Thomas Quertermous 5 Neil Risch 0