BackgroundDihydrofolate reductase (DHFR) is an important target for antimetabolite class of antimicrobials because it participates in purine synthesis. 2-mercaptobenzimidazole (2MBI) has similar structural features as purine nucleotides. Given that benzimidazole and similar heteroaromatics have been broadly examined for their anticancer potential, so, we hereby report the design...
Lim Syed Adnan Ali Shah Vasudevan Mani Balasubramanian Narasimhan 0 0 Faculty of Pharmaceutical Sciences, Maharshi Dayanand University , Rohtak 124001 , India Background: Dihydrofolate reductase (DHFR
In order to overcome the challenges of microbial resistance as well as to improve the effectiveness and selectivity of chemotherapeutic agents against cancer, a novel series of 4-(4-bromophenyl)-thiazol-2-amine derivatives was synthesized and its molecular structures were confirmed by physicochemical and spectral characteristics. The synthesized compounds were further evaluated...
Sharma1, Sanjiv Kumar1, Balasubramanian Narasimhan ORCID: orcid.org/0000-0002-9627-094X1, Kalavathy Ramasamy2,3, Siong Meng Lim2,3, Syed Adnan Ali Shah2,4 & Vasudevan Mani5 BMC Chemistry volume 13 ... AuthorsSearch for Deepika Sharma in:PubMed • Google Scholar Search for Sanjiv Kumar in:PubMed • Google Scholar Search for Balasubramanian Narasimhan in:PubMed • Google Scholar Search for Kalavathy Ramasamy
The utility of oxazole as intermediates for the synthesis of new chemical entities in medicinal chemistry have been increased in the past few years. Oxazole is an important heterocyclic nucleus having a wide spectrum of biological activities which drew the attention of researchers round the globe to synthesize various oxazole derivatives and screen them for their various...
Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, IndiaSaloni Kakkar & Balasubramanian Narasimhan AuthorsSearch for Saloni Kakkar in:PubMed • Google Scholar Search for Balasubramanian ... Narasimhan in:PubMed • Google Scholar Corresponding author Correspondence to Balasubramanian Narasimhan. Rights and permissions Open Access This article is distributed under the terms of the Creative
Array CGH is a powerful technique for genomic studies of cancer. It enables one to carry out genome-wide screening for regions of genetic alterations, such as chromosome gains and losses, or localized amplifications and deletions. In this paper, we propose a new algorithm ‘Cluster along chromosomes’ (CLAC) for the analysis of array CGH data. CLAC builds hierarchical clustering...
tables, authored or reviewed drafts of the paper, approved the final draft. Balasubramanian Narasimhan conceived and designed the experiments, authored or reviewed drafts of the paper, approved the final
BackgroundBenzimidazole is a heterocyclic moiety whose derivatives are present in many of the bioactive compounds and posses diverse biological and clinical applications. Benzimidazole agents are the vital pharmacophore and privileged sub-structures in chemistry of medicine. They have received much interest in drug discovery because benzimidazoles exhibited enormous significance...
Benzimidazole is a heterocyclic moiety whose derivatives are present in many of the bioactive compounds and posses diverse biological and clinical applications. Benzimidazole agents are the vital pharmacophore and privileged sub-structures in chemistry of medicine. They have received much interest in drug discovery because benzimidazoles exhibited enormous significance. So...
BackgroundIn continuation of our work, new diazenyl chalcones scaffolds (C-18 to C-27) were efficiently synthesized from substituted acetophenone azo dyes (A–E) by base catalyzed Claisen–Schmidt condensation with different substituted aromatic/heteroaromatic aldehydes.MethodologyThe synthesized chalcones were assessed for their in vitro antimicrobial potential towards several...
docking studies Harmeet Kaur1, Jasbir Singh2 & Balasubramanian Narasimhan ORCID: orcid.org/0000-0002-9627-094X1 BMC Chemistry volume 13, Article number: 87 (2019) Cite this article Article metrics ... for Balasubramanian Narasimhan in:PubMed • Google Scholar Contributions Authors BN and HK have designed and performed the synthesis and the biological evaluations. The author JS have done the
Cancer is one of the most serious medical problem and second leading cause of death in the world, characterized by a deregulation of the cell cycle which mainly results in a progressive loss of cellular differentiation and uncontrolled cellular growth. The benzimidazole is a heterocyclic moiety found in extensive number of natural and biological active molecules. Benzimidazole...
AffiliationsFaculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, 124001, IndiaSumit Tahlan, Sanjiv Kumar, Saloni Kakkar & Balasubramanian Narasimhan AuthorsSearch for Sumit Tahlan in:PubMed ... • Google Scholar Search for Sanjiv Kumar in:PubMed • Google Scholar Search for Saloni Kakkar in:PubMed • Google Scholar Search for Balasubramanian Narasimhan in:PubMed • Google Scholar Contributions BN
BackgroundA new series of benzoxazole analogues was synthesized and checked for their in vitro antibacterial, antifungal and anticancer activities.Results and discussionThe synthesized benzoxazole compounds were confirmed by IR, 1H/13C-NMR, mass and screened for their in vitro antimicrobial activity against Gram-positive bacterium: Bacillus subtilis, four Gram-negative bacteria...
Ramasamy2,3, Vasudevan Mani4, Syed Adnan Ali Shah2,5 & Balasubramanian Narasimhan ORCID: orcid.org/0000-0002-9627-094X1 Chemistry Central Journal volume 12, Article number: 92 (2018) Cite this article ... • Google Scholar Search for Balasubramanian Narasimhan in:PubMed • Google Scholar Corresponding author Correspondence to Balasubramanian Narasimhan. Rights and permissions Open Access This article is
BackgroundIn the past few years, increased resistance of microorganisms towards antimicrobial agents become a serious health problem, so there is a need for the discovery of new antimicrobial agents. On the other hand, bis-pyrimidines possess various types of biological activity. In view of this, in the present study we have designed and synthesized a new series of bis-pyrimidine...
in:Nature Research journals • PubMed • Google ScholarSearch for Balasubramanian Narasimhan in:Nature Research journals • PubMed • Google ScholarSearch for Roger A Warnke in:Nature Research journals • PubMed
L Assimes 5 Alan S Go 4 Mark A Hlatky Carlos Iribarren 4 Joshua W Knowles 5 Jun Li 1 Balasubramanian Narasimhan Steven Sidney 4 Audrey Southwick 3 Richard M Myers 2 Thomas Quertermous 5 Neil Risch 0
Population-based biobanks with genomic and dense phenotype data provide opportunities for generating effective therapeutic hypotheses and understanding the genomic role in disease predisposition. To characterize latent components of genetic associations, we apply truncated singular value decomposition (DeGAs) to matrices of summary statistics derived from genome-wide association...
