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Search: authors:"Bashira A. Charles"

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Analyses of genome wide association data, cytokines, and gene expression in African-Americans with benign ethnic neutropenia

. Funding acquisition: Mary Cushman, Charles N. Rotimi, Griffin P. Rodgers. Methodology: Bashira A. Charles, Matthew M. Hsieh, Adebowale A. Adeyemo, Daniel Shriner, Kyung Chin, Kshitij Srivastava, Neil A ... , Griffin P. Rodgers. Writing ± original draft: Bashira A. Charles, Matthew M. Hsieh, Adebowale A. Adeyemo, Daniel Shriner. Writing ± review & editing: Bashira A. Charles, Matthew M. Hsieh, Adebowale A

Evolutionary context for the association of γ-globin, serum uric acid, and hypertension in African Americans

Background Hyperuricemia and associated cardio-metabolic disorders are more prevalent in African Americans than in European Americans. We used genome-wide admixture mapping and association testing to identify loci with ancestry effects on serum uric acid levels. Methods We analyzed 1,976 African Americans from Washington, D.C, including 1,322 individuals from 328 pedigrees and...

A genome-wide association study of serum uric acid in African Americans

Background Uric acid is the primary byproduct of purine metabolism. Hyperuricemia is associated with body mass index (BMI), sex, and multiple complex diseases including gout, hypertension (HTN), renal disease, and type 2 diabetes (T2D). Multiple genome-wide association studies (GWAS) in individuals of European ancestry (EA) have reported associations between serum uric acid...