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Effects of Coinfection on the Dynamics of Two Pathogens in a Tick-Host Infection Model

Research Article | Open Access Volume 2020 |Article ID 5615173 | https://doi.org/10.1155/2020/5615173 Bei Sun, Xue Zhang, Marco Tosato, "Effects of Coinfection on the Dynamics of Two ... Pathogens in a Tick-Host Infection Model Bei Sun,1 Xue Zhang,1 and Marco Tosato2 1College of Science, Northeastern University, Shenyang, Liaoning 110819, China 2Laboratory for Industrial and Applied

Unfolded protein response in colorectal cancer

Colorectal cancer (CRC) is a gastrointestinal malignancy originating from either the colon or the rectum. A growing number of researches prove that the unfolded protein response (UPR) is closely related to the occurrence and progression of colorectal cancer. The UPR has three canonical endoplasmic reticulum (ER) transmembrane protein sensors: inositol requiring kinase 1 (IRE1...

Ferroptosis: past, present and future

Ferroptosis is a new type of cell death that was discovered in recent years and is usually accompanied by a large amount of iron accumulation and lipid peroxidation during the cell death process; the occurrence of ferroptosis is iron-dependent. Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease...

Intestinal flora imbalance affects bile acid metabolism and is associated with gallstone formation

, Youzheng Street 23, Harbin, 150001, ChinaQiang Wang, Chenjun Hao, Wenchao Yao, Defu Zhu, Haifeng Lu, Long Li, Biao Ma, Bei Sun, Dongbo Xue & Weihui Zhang AuthorsQiang Wang View author publications You can ... search for this author in PubMed Google Scholar Bei Sun View author publications You can also search for this author in PubMed Google Scholar Dongbo Xue View author publications You can also search

Recent advances in research on aspartate β-hydroxylase (ASPH) in pancreatic cancer: A brief update

Pancreatic cancer (PC) is a highly aggressive tumor, often difficult to diagnose and treat. Aspartate β-hydroxylase (ASPH) is a type II transmembrane protein and the member of α-ketoglutarate-dependent dioxygenase family, found to be overexpressed in different cancer types, including PC. ASPH appears to be involved in the regulation of proliferation, invasion and metastasis of PC...

Propofol inhibited autophagy through Ca2+/CaMKKβ/AMPK/mTOR pathway in OGD/R-induced neuron injury

The neuroprotective role of propofol (PPF) in cerebral ischemia-reperfusion (I/R) has recently been highlighted. This study aimed to explore whether the neuroprotective mechanisms of PPF were linked to its regulation of Ca2+/CaMKKβ (calmodulin-dependent protein kinase kinase β)/AMPK (AMP-activated protein kinase)/mTOR (mammalian target of rapamycin)/autophagy pathway. Cultured...

Hypoxia-Inducible Factor-1α Knockdown Plus Glutamine Supplementation Attenuates the Predominance of Necrosis over Apoptosis by Relieving Cellular Energy Stress in Acute Pancreatitis

Guo,1 Jiachen Lv,2 Fan Xiao,1 Wangjun Zhang,1 Jie Li,1 Zhitao Lin,1 Bei Sun,1 and Gang Wang1 1The Department of General Surgery, The No. 1 Affiliated Hospital of Harbin Medical University, Harbin

UBL4A inhibits autophagy-mediated proliferation and metastasis of pancreatic ductal adenocarcinoma via targeting LAMP1

• Google Scholar Search for Yilong Li in:PubMed • Google Scholar Search for Hua Chen in:PubMed • Google Scholar Search for Shangha Pan in:PubMed • Google Scholar Search for Bei Sun in:PubMed • Google ... the IHC. All authors read and approved the final manuscript. Corresponding author Correspondence to Bei Sun. Ethics declarations Ethics approval and consent to participate PDAC and normal

Pancreatic kallikrein protects against diabetic retinopathy in KK Cg-Ay/J and high-fat diet/streptozotocin-induced mouse models of type 2 diabetes

Aims/hypothesisMany studies have shown that tissue kallikrein has effects on diabetic vascular complications such as nephropathy, cardiomyopathy and neuropathy, but its effects on diabetic retinopathy are not fully understood. Here, we investigated the retinoprotective role of exogenous pancreatic kallikrein and studied potential mechanisms of action.MethodsWe used KK Cg-Ay/J...

Inhibition of RIPK1-dependent regulated acinar cell necrosis provides protection against acute pancreatitis via the RIPK1/NF-κB/AQP8 pathway

Currently, preliminary results have confirmed the existence of receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like protein (MLKL)-dependent necroptosis of pancreatic acinar cells during early acute pancreatitis (AP), which might be a potential target for the effective regulation of necroinflammatory injury. However, the exact effect of receptor...

SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart

Hyperglycaemia associated with myocardial oxidative stress and fibrosis is the main cause of diabetic cardiomyopathy. Empagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor has recently been reported to improve glycaemic control in patients with type 2 diabetes in an insulin-independent manner. The aim of this study was to investigate the effect of empagliflozin on...

Total thyroidectomy as primary surgical management for thyroid disease: surgical therapy experience from 5559 thyroidectomies in a less-developed region

Background The objective of this study was to evaluate the safety of total thyroidectomy for thyroid disorders and summarise the treatment experience in a less-developed region. Methods This was a retrospective observational cohort study using the computerised database of the First Affiliated Hospital of Harbin Medical University. All consecutive thyroidectomy patients from 2003...

Total thyroidectomy as primary surgical management for thyroid disease: surgical therapy experience from 5559 thyroidectomies in a less-developed region

The objective of this study was to evaluate the safety of total thyroidectomy for thyroid disorders and summarise the treatment experience in a less-developed region. This was a retrospective observational cohort study using the computerised database of the First Affiliated Hospital of Harbin Medical University. All consecutive thyroidectomy patients from 2003 to 2014 were...

Pancreatic Acinar Cells Employ miRNAs as Mediators of Intercellular Communication to Participate in the Regulation of Pancreatitis-Associated Macrophage Activation

 Xin Qiao,2 Bei Sun,1 Weihui Zhang,1 and Dongbo Xue1 1Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China 2Department of Surgery

Pancreatic Acinar Cells Employ miRNAs as Mediators of Intercellular Communication to Participate in the Regulation of Pancreatitis-Associated Macrophage Activation

 Xin Qiao,2 Bei Sun,1 Weihui Zhang,1 and Dongbo Xue1 1Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China 2Department of Surgery

Pancreatic Acinar Cells Employ miRNAs as Mediators of Intercellular Communication to Participate in the Regulation of Pancreatitis-Associated Macrophage Activation

 Xin Qiao,2 Bei Sun,1 Weihui Zhang,1 and Dongbo Xue1 1Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China 2Department of Surgery

Pancreatic Acinar Cells Employ miRNAs as Mediators of Intercellular Communication to Participate in the Regulation of Pancreatitis-Associated Macrophage Activation

 Xin Qiao,2 Bei Sun,1 Weihui Zhang,1 and Dongbo Xue1 1Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, China 2Department of Surgery

Angelica Dahurica ethanolic extract improves impaired wound healing by activating angiogenesis in diabetes

Abnormal angiogenesis plays an important role in impaired wound healing and development of chronic wounds in diabetes mellitus. Angelica dahurica radix is a common traditional Chinese medicine with wide spectrum medicinal effects. In this study, we analyzed the potential roles of Angelica dahurica ethanolic extract (ADEE) in correcting impaired angiogenesis and delayed wound...

ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis

Fuliang He in:PubMed • Google Scholar Search for Xuewei Bai in:PubMed • Google Scholar Search for Bei Sun in:PubMed • Google Scholar Search for Mien-Chie Hung in:PubMed • Google Scholar Search for