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8 papers found.
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Sliding Window Top-K Monitoring over Distributed Data Streams

Most of the traditional top-k algorithms are based on a single-server setting. They may be highly inefficient and/or cause huge communication overhead when applied to a distributed system environment. Therefore, the problem of top-k monitoring in distributed environments has been intensively investigated recently. This paper studies how to monitor the top-k data objects with the...

Increased half-life and enhanced potency of Fc-modified human PCSK9 monoclonal antibodies in primates

Li. Data curation: Hua Li. Formal analysis: Li Zhao. Funding acquisition: Yong Su. Investigation: Qingsong Guo, Bei Gao. Methodology: Ben Chen. Project administration: Yijun Shen. Resources ... : Jinsong Wu. 12 / 14 Software: Tong Yang. Supervision: Yijun Shen. Validation: Li Zhao, Ben Chen. Writing ± original draft: Hua Li. Writing ± review & editing: Yijun Shen, Li Jin. 13 / 14 1. Seidah NG

T0001, a variant of TNFR2-Fc fusion protein, exhibits improved Fc effector functions through increased binding to membrane-bound TNFα

T0001 is a recombinant human TNFR-Fc fusion protein mutant; it exhibits higher affinity to TNFα than etanercept and is now being tested in a Phase 1 study in China ( Identifier: NCT02481180). T0001 can inhibit the binding of soluble TNFα (sTNFα) or membrane-bound TNFα (mTNFα) to TNF receptors. When bound to mTNFα, the Fc-bearing TNFα antagonists have the...

Antibacterial Activity and Kinetics of Litsea cubeba Oil on Escherichia coli

Xiao-Mo Huang 0 Yi-Ben Chen 0 Yiguo Hong, CAS, China 0 State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application

U-Shape Suppressive Effect of Phenol Red on the Epileptiform Burst Activity via Activation of Estrogen Receptors in Primary Hippocampal Culture

Phenol red is widely used in cell culture as a pH indicator. Recently, it also has been reported to have estrogen-like bioactivity and be capable of promoting cell proliferation in different cell lines. However, the effect of phenol red on primary neuronal culture has never been investigated. By using patch clamp technique, we demonstrated that hippocampal pyramidal neurons...

Pulse Width Modulation Electro-Acupuncture on Cardiovascular Remodeling and Plasma Nitric Oxide in Spontaneously Hypertensive Rats

This study was designed to investigate the effect of pulse width modulation electro-acupuncture (PWM-EA) on cardiovascular remodeling and nitric oxide (NO) in spontaneously hypertensive rats (SHR). Thirty-four male SHR were randomly divided into control, captopril, and two PWM-EA groups, which were treated with 350 Hz (SHR-350 Hz) and whole audio bandwith electro-acupuncture (SHR...

SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status

The Bcl-2 family of proteins is critical to the life and death of malignant B-lymphocytes. Interfering with their activity using small-molecule inhibitors (SMI) is being explored as a new therapeutic strategy for treating B-cell tumors. We evaluated the efficacy of TW-37, a non-peptidic SMI of Bcl-2 against a range spectrum of human B-cell lines, fresh patient samples and animal...