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A Feedback-Based Approach to Utilizing Embeddings for Clinical Decision Support

Clinical Decision Support (CDS) is widely seen as an information retrieval (IR) application in the medical domain. The goal of CDS is to help physicians find useful information from a collection of medical articles with respect to the given patient records, in order to take the best care of their patients. Most of the existing CDS methods do not sufficiently consider the semantic...

Xuezhikang, an extract from red yeast rice, attenuates vulnerable plaque progression by suppressing endoplasmic reticulum stress-mediated apoptosis and inflammation

work related to this manuscript was performed at Shanghai Chest Hospital and Renji Hospital, Shanghai Jiaotong Conceptualization: Linghong Shen, Zhe Sun, Shichun Chu, Ben He. Data curation: Zhe Sun ... , Shichun Chu. Formal analysis: Zhe Sun, Shichun Chu. Funding acquisition: Linghong Shen, Zhe Sun, Liuhua Hu, Ben He. Investigation: Zhe Sun, Shichun Chu. Methodology: Zhe Sun, Shichun Chu, Zhaohua Cai

Rational transplant timing and dose of mesenchymal stromal cells in patients with acute myocardial infarction: a meta-analysis of randomized controlled trials

Background Mesenchymal stromal cells (MSCs) are considered to have a modest benefit on left ventricular ejection fraction (LVEF) in patients with acute myocardial infarction (AMI). However, the optimal injection timing and dose needed to induce beneficial cardiac effects are unknown. The purpose of this meta-analysis was to identify an optimal MSC transplantation time and cell...

A systematic review of randomised controlled trials examining the therapeutic effects of adult bone marrow-derived stem cells for non-ischaemic dilated cardiomyopathy

cardiomyopathy Yi Lu 0 Yiqin Wang 0 Menglu Lin Jiale Zhou Zi Wang Meng Jiang Ben He 0 Equal contributors Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University , 160 Pujian

Bestrophin 3 Ameliorates TNFα-Induced Inflammation by Inhibiting NF-κB Activation in Endothelial Cells

Citation: Song W, Yang Z, He B ( Bestrophin 3 Ameliorates TNFa-Induced Inflammation by Inhibiting NF-kB Activation in Endothelial Cells Wei Song 0 Zhen Yang 0 Ben He 0 Christina L. Addison, Ottawa

Image-guided left ventricular lead placement in cardiac resynchronization therapy for patients with heart failure: a meta-analysis

-liang Mao Ben He 0 Equal contributors Department of Cardiology, Ren Ji hospital, School of Medicine, Shanghai Jiao Tong University , 200001 Shanghai , China Background: Heart failure (HF) is a

Functional Relevance of Protein Glycosylation to the Pro-Inflammatory Effects of Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) on Monocytes/Macrophages

Background and Objective Extracellular matrix metalloproteinase inducer (EMMPRIN) is an important pro-inflammatory protein involved in the cellular functions of monocytes/macrophages. We have hypothesized that high-level heterogeneousness of protein glycosylation of EMMPRIN may have functional relevance to its biological effects and affect the inflammatory activity of monocytes...

A Novel Method in the Stratification of Post-Myocardial-Infarction Patients Based on Pathophysiology

Objectives We proposed that the severity of ST-segment elevation myocardial infarction (STEMI) could be classified based on pathophysiological changes. Methods First-STEMI patients were classified within hospitalization. Grade 0: no detectable myocardial necrosis; Grade 1: myocardial necrosis without functional and morphological abnormalities; Grade 2: myocardial necrosis with...

Liver X receptor agonist treatment attenuates cardiac dysfunction in type 2 diabetic db/db mice

Background Liver X receptor (LXR) plays a critical regulatory role in metabolism and inflammation, and has been demonstrated to be involved in cardiovascular physiology/pathology. In the present study, we investigated the effect of GW3965, a potent LXR agonist, on diabetic cardiomyopathy (DCM) in type 2 diabetic db/db mice. Methods and Results Non-diabetic db/+ mice and diabetic...

Two-Dimensional Echocardiography in the Assessment of Long-Term Prognosis in Patients with Pulmonary Arterial Hypertension

Objective To investigate the relationship between cardiac diastolic dysfunction and outcomes in patients with pulmonary arterial hypertension (PAH) and to clarify the potential effect of two-dimensional echocardiography (2D-echo) on prognostic value in patients with PAH. Methods Patients diagnosed with PAH (as WSPH (World Symposia on Pulmonary Hypertension) classification I...

Orphan nuclear receptor Nur77 Inhibits Oxidized LDL-induced differentiation of RAW264.7 murine macrophage cell line into dendritic like cells

Nie Zhao-hua Cai Ming-li Cui Shi-qun Sun Hua Xiao Qin Shao Ling-hong Shen Ben He 0 Equal contributors Department of Cardiology, Renji Hospital, Shanghai Jiaotong University School of Medicine

Association between Tissue Characteristics of Coronary Plaque and Distal Embolization after Coronary Intervention in Acute Coronary Syndrome Patients: Insights from a Meta-Analysis of Virtual Histology-Intravascular Ultrasound Studies

Background and Objectives The predictive value of plaque characteristics assessed by virtual histology-intravascular ultrasound (VH-IVUS) including fibrous tissue (FT), fibrofatty (FF), necrotic core (NC) and dense calcium (DC) in identifying distal embolization after percutaneous coronary intervention (PCI) is still controversial. We performed a systematic review and meta...

Atorvastatin Improves Plaque Stability in ApoE-Knockout Mice by Regulating Chemokines and Chemokine Receptors

It is well documented that statins protect atherosclerotic patients from inflammatory changes and plaque instability in coronary arteries. However, the underlying mechanisms are not fully understood. Using a previously established mouse model for vulnerable atherosclerotic plaque, we investigated the effect of atorvastatin (10 mg/kg/day) on plaque morphology. Atorvastatin did not...

The expression and significance of proto-oncogene c-fos in viral myocarditis

Background c-fos may play a role in the pathogenesis of some diseases. The expression and function of c-fos in viral myocarditis (VMC) have not yet been reported. To study the change and significance of proto-oncogene c-fos in VMC is the objective of this experiment. Methods An animal model of VMC was established via coxsackie virus B3 inoculation. VMC mice were then treated with...