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Gender differences in functional connectivities between insular subdivisions and selective pain-related brain structures

BackgroundThe incidence of pain disorders in women is higher than in men, making gender differences in pain a research focus. The human insular cortex is an important brain hub structure for pain processing and is divided into several subdivisions, serving different functions in pain perception. Here we aimed to examine the gender differences of the functional connectivities (FCs...

Prevalence of stroke and associated risk factors among middle-aged and older farmers in western China

Objectives China has the world’s largest population and the stroke has become the leading cause of death in recent years. The purpose of this study was to explore the associations between hypertension, family history of stroke, diabetes mellitus, obesity and stroke among middle-aged and older farmers of western China. A population-based study was conducted from June 2014 to April...

POS: A High-Level System to Simplify Real-Time Stream Application Development on Storm

Real-time stream computing becomes increasingly important due to the sheer amount of content continually generated in various kinds of social networks and e-commerce websites. Many distributed real-time computing systems have been built for different applications, and Storm is one of the most prominent systems with high-performance, fault-tolerance and low-latency features...

The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/β-catenin signaling

Background With more than 600,000 mortalities each year, colorectal cancer (CRC) is the third most commonly diagnosed type of cancer worldwide. Recently, mechanisms involving noncoding RNAs have been implicated in the development of CRC. Methods We examined expression levels of lncRNA CRNDE and miR-181a-5p in 64 cases of CRC tissues and cell lines by qRT-PCR. Gain-of-function and...

The surgical management of hypertrophic obstructive cardiomyopathy with the concomitant mitral valve abnormalities

OBJECTIVES The purpose of this retrospective study was to analyse the pathogenesis and the treatment strategies of hypertrophic obstructive cardiomyopathy (HOCM) with the concomitant mitral valve abnormalities.

The imaging features of metanephric adenoma: a case report and review of literature

The imaging features of metanephric adenoma: a case report and review of literature Yu-Chuan Hu,1,* Lang Wu,2,* Lin-Feng Yan,1 Wei Zhang,3 Guang-Bin Cui1 1Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi'an, People’s Republic of China; 2Center for Clinical and Translational Science, Mayo Clinic, Rochester, MN, USA; 3Department of Pathology...

The results of a two-stage double switch operation for congenital corrected transposition of the great arteries with a deconditioned morphologically left ventricle

OBJECTIVES The purpose of this retrospective study was to evaluate a two-stage double switch operation, morphological left ventricular (mLV) retraining followed by an atrial–arterial switch operation, in the management of patients with congenitally corrected transposition of the great arteries (CCTGA) and a deconditioned mLV.

Screening and selection of peptides specific for esophageal cancer cells from a phage display peptide library

Shi-Yun Feng 0 You-Bin Cui 0 0 Department of Thoracic Surgery, The First Hospital of Jilin University , 71 Xinmin Street, 130021 Changchun , China 1 Department of Gynaecology and Obstetrics, The First

PFN2, a novel marker of unfavorable prognosis, is a potential therapeutic target involved in esophageal squamous cell carcinoma

Background Esophageal squamous cell carcinoma (ESCC) is one of the most aggressively malignant tumors with dismal prognosis. Profilin 2 (PFN2) is an actin-binding protein that regulates the dynamics of actin polymerization and plays a key role in cell motility. Recently, PFN2 have emerged as significant regulators of cancer processes. However, the clinical significance and...

Correlation of Abdominal Fat Distribution with Different Types of Diabetes in a Chinese Population

To investigate abdominal fat distribution in Chinese subjects with diabetes and its correlation with different types of diabetes. A total of 176 diabetic subjects were enrolled, 92 with type 1 and 84 with type 2, with a mean age of 27.41 and 49.3 yrs. No subject has history of severe diseases. Multi-slice CT was used to measure total abdominal adipose (TA) and visceral adipose...

Predicting Subtypes of Thymic Epithelial Tumors Using CT: New Perspective based on a Comprehensive Analysis of 216 Patients

journals • PubMed • Google ScholarSearch for Bei Zhang in:Nature Research journals • PubMed • Google ScholarSearch for Guang-Bin Cui in:Nature Research journals • PubMed • Google Scholar Contributions G.-B.C ... interests The authors declare no competing financial interests. Corresponding author Correspondence to Guang-Bin Cui. Supplementary information Word documents1.Supplementary Information Supplementary

Does Dexmedetomidine as a Neuraxial Adjuvant Facilitate Better Anesthesia and Analgesia? A Systematic Review and Meta-Analysis

Background Neuraxial application of dexmedetomidine (DEX) as adjuvant analgesic has been invetigated in some randomized controlled trials (RCTs) but not been approved because of the inconsistency of efficacy and safety in these RCTs. We performed this meta-analysis to access the efficacy and safety of neuraxial DEX as local anaesthetic (LA) adjuvant. Methods We searched PubMed...

Cytosporinols A-C, new caryophyllene sesquiterpenoids from Cytospora sp.

Three new caryophyllene sesquiterpenoids, cytosporinols A-C (1–3), have been isolated from solid cultures of Cytospora sp. The structures of 1–3 were elucidated primarily by NMR spectroscopy, and 3 was further confirmed by X-ray crystallography. The absolute configurations of the C-11 secondary alcohol in 1 and the 6,8-diol moiety in 3 were deduced using the modified Mosher and...

Intravoxel incoherent motion diffusion-weighted MR imaging of gliomas: efficacy in preoperative grading

in:Nature Research journals • PubMed • Google ScholarSearch for Wen Wang in:Nature Research journals • PubMed • Google ScholarSearch for Guang-Bin Cui in:Nature Research journals • PubMed • Google Scholar ... interests T-YX is an employee of GE healthcare Greater China. All other authors declare no conflict of interests. Corresponding authors Correspondence to Wen Wang or Guang-Bin Cui. Rights and permissions

Serum Liver Fatty Acid Binding Protein Levels Correlate Positively with Obesity and Insulin Resistance in Chinese Young Adults

Background Liver fatty acid–binding protein (FABP1) plays an inconclusive role in adiposity. We investigated the association of serum FABP1 levels with obesity and insulin resistance in Chinese young people under 30 years old. Methodology and Principal Findings Cross-sectional analysis including 200 obese and 172 normal-weight subjects matched for age and sex, anthropometric...

Chemokine (C-C Motif) Ligand 20, a Potential Biomarker for Graves' Disease, Is Regulated by Osteopontin

Context Graves’ disease (GD) is a common autoimmune disease involving the thyroid gland. The altered balance of pro- and anti-inflammatory cytokines plays an important role in the pathogenesis of GD. Chemokine (C-C motif) ligand 20 (CCL20) is important for interleukin-17 (IL-17) signal activation and a potent chemoattractant for Th17 cells. Meanwhile, Osteopontin (OPN), a broadly...

SLC39A6: a potential target for diagnosis and therapy of esophageal carcinoma

Background Esophageal squamous cell carcinoma (ESCC) is a highly lethal cancer, and its underlying molecular mechanisms are poorly understood. Recent large-scale genome-wide association studies in Chinese Han populations have identified an ESCC susceptibility locus within the SLC39A6 gene. Here, we sought to explore the expression and biological function of SLC39A6 in ESCC...

Analysis of PTEN Methylation Patterns in Soft Tissue Sarcomas by MassARRAY Spectrometry

Soft tissue sarcomas (STSs) are a rare and fascinating group of diseases that can be subdivided into specific reciprocal translocations in STSs (SRTSs) and nonspecific reciprocal translocations in STSs (NRTSs). PTEN mutations are rare in STSs, suggesting that PTEN expression may be lost by alternative mechanisms such as methylation. In order to reveal whether aberrant PTEN...

Removal of Hsf4 leads to cataract development in mice through down-regulation of γS-crystallin and Bfsp expression

Background Heat-shock transcription factor 4 (HSF4) mutations are associated with autosomal dominant lamellar cataract and Marner cataract. Disruptions of the Hsf4 gene cause lens defects in mice, indicating a requirement for HSF4 in fiber cell differentiation during lens development. However, neither the relationship between HSF4 and crystallins nor the detailed mechanism of...

A Genome-Wide Association Study Confirms Previously Reported Loci for Type 2 Diabetes in Han Chinese

Background Genome-wide association study (GWAS) has identified more than 30 loci associated with type 2 diabetes (T2D) in Caucasians. However, genomic understanding of T2D in Asians, especially Han Chinese, is still limited. Methods and Principal Findings A two-stage GWAS was performed in Han Chinese from Mainland China. The discovery stage included 793 T2D cases and 806 healthy...