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Multiple Cayley-Klein metric learning

: Yanhong Bi. Formal analysis: Yanhong Bi, Bin Fan, Fuchao Wu. Funding acquisition: Bin Fan, Fuchao Wu. Investigation: Yanhong Bi. Methodology: Yanhong Bi, Bin Fan, Fuchao Wu. Resources: Fuchao Wu ... . Software: Yanhong Bi. Supervision: Bin Fan, Fuchao Wu. 13 / 15 Writing ± original draft: Yanhong Bi. Writing ± review & editing: Bin Fan. 14 / 15 1. MacQueen JB . On convergence of k-means and partitions

Green and efficient dry gel conversion synthesis of SAPO-34 catalyst with plate-like morphology

SAPO-34 catalyst with plate-like morphology was designed and synthesized for the first time, by the dry gel conversion method using cheap triethylamine as a structure-directing agent assisted with seed suspension containing nanosheet-like SAPO-34 seed. The latter played an important role in formation of SAPO-34 (CHA-type) with plate-like morphology. In addition, the yield of the ...

Iterative Usage of Fixed and Random Effect Models for Powerful and Efficient Genome-Wide Association Studies

False positives in a Genome-Wide Association Study (GWAS) can be effectively controlled by a fixed effect and random effect Mixed Linear Model (MLM) that incorporates population structure and kinship among individuals to adjust association tests on markers; however, the adjustment also compromises true positives. The modified MLM method, Multiple Loci Linear Mixed Model (MLMM), ...

Pycnogenol Attenuates the Release of Proinflammatory Cytokines and Expression of Perilipin 2 in Lipopolysaccharide-Stimulated Microglia in Part via Inhibition of NF-κB and AP-1 Activation

Over activation of microglia results in the production of proinflammatory agents that have been implicated in various brain diseases. Pycnogenol is a patented extract from French maritime pine bark (Pinus pinaster Aiton) with strong antioxidant and anti-inflammatory potency. The present study investigated whether pycnogenol may be associated with the production of proinflammatory ...

A genome-wide scan for signatures of selection in Chinese indigenous and commercial pig breeds

Background Modern breeding and artificial selection play critical roles in pig domestication and shape the genetic variation of different breeds. China has many indigenous pig breeds with various characteristics in morphology and production performance that differ from those of foreign commercial pig breeds. However, the signatures of selection on genes implying for economic traits ...

The luminescence properties of Sr3Gd(BO3)3: Tb3+ phosphors under vacuum ultraviolet excitation

Tb3+-activated Sr3Gd(BO3)3 green phosphors were prepared by conventional solid-state reaction. The vacuum ultraviolet (VUV) excitation, photoluminescence (PL) and decay properties of the phosphors in the visible range were investigated. The excitation spectrum showed a strong broad band from 160 to 200 nm with a maximum at 183 nm which was adjacent to the VUV excitation light ...

Japanese encephalitis virus infects porcine kidney epithelial PK15 cells via clathrin- and cholesterol-dependent endocytosis

Background Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that causes acute viral encephalitis in humans. Pigs are important amplifiers of JEV. The entry mechanism of JEV into porcine cells remains largely unknown. In this study, we present a study of the internalization mechanism of JEV in porcine kidney epithelial PK15 cells. Results We demonstrated that the ...

Analysis of Genome-Wide Copy Number Variations in Chinese Indigenous and Western Pig Breeds by 60 K SNP Genotyping Arrays

Copy number variations (CNVs) represent a substantial source of structural variants in mammals and contribute to both normal phenotypic variability and disease susceptibility. Although low-resolution CNV maps are produced in many domestic animals, and several reports have been published about the CNVs of porcine genome, the differences between Chinese and western pigs still remain ...

Photoluminescence and cathodoluminescence properties of a novel CaLaGa3O7:Dy3+ phosphor

A single host white emitting phosphor, CaLaGa3O7:Dy3+, was synthesized by chemical co-precipitation. Field emission scanning electron microscopy, X-ray diffraction, laser particle size analysis, and photoluminescence and cathodoluminescence spectra were used to investigate the structural and optical properties of the phosphor. The phosphor particles were composed of microspheres ...

Development of loop-mediated isothermal amplification assay for specific and rapid detection of differential goat Pox virus and Sheep Pox virus

Background Capripox viruses are economically important pathogens in goat and sheep producing areas of the world, with specific focus on goat pox virus (GTPV), sheep pox virus (SPPV) and the Lumpy Skin Disease virus (LSDV). Clinically, sheep pox and goat pox have the same symptoms and cannot be distinguished serologically. This presents a real need for a rapid, inexpensive, and easy ...

Up-regulation of microglial cathepsin C expression and activity in lipopolysaccharide-induced neuroinflammation

BackgroundCathepsin C (Cat C) functions as a central coordinator for activation of many serine proteases in inflammatory cells. It has been recognized that Cat C is responsible for neutrophil recruitment and production of chemokines and cytokines in many inflammatory diseases. However, Cat C expression and its functional role in the brain under normal conditions or in ...

Meningothelial Cells React to Elevated Pressure and Oxidative Stress

Background Meningothelial cells (MECs) are the cellular components of the meninges enveloping the brain. Although MECs are not fully understood, several functions of these cells have been described. The presence of desmosomes and tight junctions between MECs hints towards a barrier function protecting the brain. In addition, MECs perform endocytosis and, by the secretion of ...

Genome-Wide Association Study Identifies Loci for Body Composition and Structural Soundness Traits in Pigs

Background The recent completion of the swine genome sequencing project and development of a high density porcine SNP array has made genome-wide association (GWA) studies feasible in pigs. Methodology/Principal Findings Using Illumina's PorcineSNP60 BeadChip, we performed a pilot GWA study in 820 commercial female pigs phenotyped for backfat, loin muscle area, body conformation in ...

Evidence of d-phenylglycine as delivering tool for improving l-dopa absorption

Background l-Dopa has been used for Parkinson's disease management for a long time. However, its wide variety in the rate and the extent of absorption remained challenge in designing suitable therapeutic regime. We report here a design of using d-phenylglycine to guard l-dopa for better absorption in the intestine via intestinal peptide transporter I (PepT1). Methods ...

Clinical application of human β-defensin and CD14 gene polymorphism in evaluating the status of chronic inflammation

Background Periodontitis is a common disease that affects the periodontal tissue supporting the teeth. This disease is attributed to multiple risk factors, including diabetes, cigarette smoking, alcohol, pathogenic microorganisms, genetics and others. Human beta-defensin-1 (hBD-1) is a cationic antimicrobial peptide with cysteine-rich ß-sheets and broad-spectrum antimicrobial ...

Gene polymorphism and protein of human pro- and anti-inflammatory cytokines in Chinese healthy subjects and chronic periodontitis patients

Wings TY Loo 0 Chang-bin Fan Lan-jun Bai Yuan Yue Yi-ding Dou Min Wang Hao Liang Mary NB Cheung Louis WC Chow 0 Jin-le Li Ye Tian Liu Qing 0 0 UNIMED Medical Institute , Hong Kong SAR Background

Comparing serum levels of cardiac biomarkers in cancer patients receiving chemotherapy and subjects with chronic periodontitis

Background Chronic periodontitis (CP) is a chronic inflammation associated with elevations of several inflammatory and cardiac markers. Studies implicated CP as one of the etiologies in coronary heart disease (CHD). Cardiotoxicity is a major complication of anticancer drugs, including anthracyclines and 5-fluorouracil (5FU). The most severe cardiac complications are heart failure, ...

Large-scale association study for structural soundness and leg locomotion traits in the pig

Background Identification and culling of replacement gilts with poor skeletal conformation and feet and leg (FL) unsoundness is an approach used to reduce sow culling and mortality rates in breeding stock. Few candidate genes related to soundness traits have been identified in the pig. Methods In this study, 2066 commercial females were scored for 17 traits describing body ...

MiRFinder: an improved approach and software implementation for genome-wide fast microRNA precursor scans

Background MicroRNAs (miRNAs) are recognized as one of the most important families of non-coding RNAs that serve as important sequence-specific post-transcriptional regulators of gene expression. Identification of miRNAs is an important requirement for understanding the mechanisms of post-transcriptional regulation. Hundreds of miRNAs have been identified by direct cloning and ...

Genetic diversity and C2-like subgenogroup strains of enterovirus 71, Taiwan, 2008

Background Human enterovirus 71 (EV-71) is known of having caused numerous outbreaks of hand-foot-mouth disease, and other clinical manifestations globally. In 2008, 989 EV-71 strains were isolated in Taiwan. Results In this study, the genetic and antigenic properties of these strains were analyzed and the genetic diversity of EV-71 subgenogroups surfacing in Taiwan was depicted, ...