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Lack of coordination between partners: investigation of Physician-Preferred and Patient-Preferred (4P) basal insulin titration algorithms in the real world

Xiaodan Zhang,2 Xiaowei Li,2 Ruike Liu,3 Yunlin Wang,4 Bo Chen,5 Ling He,6 Wangen Li2 1Department of Endocrinology, The Third Affiliated Hospital, Southern Medical University, Guangzhou 510630, People’s ... chen 5 ling he 6 Wangen li 2 Background: Patient-centered care is respectful to a patient's preference. All prior clinical trials on patient self-titration algorithms for basal insulin were decided by

Rotating magnetic field-controlled fabrication of magnetic hydrogel with spatially disk-like microstructures

Composite biomaterials with controllable microstructures play an increasingly important role in tissue engineering and regenerative medicine. Here, we report a magnetic hydrogel composite with disk-like microstructure fabricated by assembly of iron oxide nanoparticles during the gelation process in the presence of rotating magnetic field. It should be mentioned that the iron...

Oncological outcome of complete response after neoadjuvant chemotherapy for breast conserving surgery: a systematic review and meta-analysis

With limited sample sizes and single-institution designs, how complete response (CR) after neoadjuvant chemotherapy (NAC) influences breast conserving surgery (BCS) and its value in prognosis are not clear. A systematic research review was conducted using electronic database. The rate of clinical complete response (cCR) in BCS after NAC and these pathological CR (PCR) and non-pCR...

Oncological outcome of complete response after neoadjuvant chemotherapy for breast conserving surgery: a systematic review and meta-analysis

With limited sample sizes and single-institution designs, how complete response (CR) after neoadjuvant chemotherapy (NAC) influences breast conserving surgery (BCS) and its value in prognosis are not clear. A systematic research review was conducted using electronic database. The rate of clinical complete response (cCR) in BCS after NAC and these pathological CR (PCR) and non-pCR...

Who should cast the casting vote? Using sequential voting to amalgamate information

In this study, we are concerned with how agents can best amalgamate their private information about a binary state of Nature. The agents are heterogeneous in their “ability”, the quality of their private information. The agents cannot directly communicate their private information but instead can only vote between the two states (say “Innocent” or “Guilty” on a criminal jury). We...

Efficacy of PI3K/AKT/mTOR pathway inhibitors for the treatment of advanced solid cancers: A literature-based meta-analysis of 46 randomised control trials

Contributions Conceptualization: Xuan Li, Weidong Wei. Data curation: Xuan Li, Danian Dai, Bo Chen. Formal analysis: Xuan Li, Danian Dai, Hailin Tang. Funding acquisition: Hailin Tang, Xiaoming Xie. Methodology ... : Bo Chen. Project administration: Weidong Wei. Software: Bo Chen. Supervision: Xiaoming Xie. Validation: Hailin Tang, Xiaoming Xie. Visualization: Weidong Wei. Writing ± original draft: Xuan Li

Damage Model of Reinforced Concrete Members under Cyclic Loading

Based on the Kumar damage model, a new damage model for reinforced concrete members is established in this paper. According to the damage characteristics of reinforced concrete members subjected to cyclic loading, four judgment conditions for determining the rationality of damage models are put forward. An ideal damage index (D) is supposed to vary within a scale of zero (no...

Role of metastasis-associated protein 1 in prognosis of patients with digestive tract cancers: A meta-analysis

eligible study by two investigators (Guo-dong Cao, Bo Chen). Any disagreement was resolved through discussion until a consensus was reached. The following data were extracted: first author's name, year of

Non-Invasive Multimodality Imaging Directly Shows TRPM4 Inhibition Ameliorates Stroke Reperfusion Injury

The transient receptor potential melastatin 4 (TRPM4) channel has been suggested to play a key role in the treatment of ischemic stroke. However, in vivo evaluation of TRPM4 channel, in particular by direct channel suppression, is lacking. In this study, we used multimodal imaging to assess edema formation and quantify the amount of metabolically functional brain salvaged after a...

All-trans retinoic acid suppresses malignant characteristics of CD133-positive thyroid cancer stem cells and induces apoptosis

Jiang. Funding acquisition: Ling Jiang. Investigation: Shan Xiao. Methodology: Bin Lv. Software: Bo Chen. Visualization: Yan Xie. Writing ± original draft: Dan Mei. Writing ± review & editing: Dan

Involvement of poly(ADP-ribose) polymerase-1 in development of spinal cord injury in Chinese individuals: a Chinese clinical study

-De Yu, Bo Chen, Li Jiang, Jing-Bo Shang Department of Spine Surgery, The Third People’s Hospital of Dalian, Dalian, People’s Republic of China *These authors contributed equally to this work Objective

Liver fibrosis detection and staging: a comparative study of T1ρ MR imaging and 2D real-time shear-wave elastography

Purpose To compare the results of T1ρ MR imaging and 2D real-time shear-wave elastography (SWE) for liver fibrosis detection and staging. Methods Twenty-nine rabbit models of CCl4-induced liver fibrosis were established and six untreated rabbits served as controls. T1ρ MR imaging and 2D real-time SWE examination were performed at 2, 4, 6, 8, 10, and 12 weeks. T1ρ values and liver...

Two Novel Vesicle-Inducing Proteins in Plastids 1 Genes Cloned and Characterized in Triticum urartu

Vesicle-inducing protein in plastids 1 (Vipp1) is thought to play an important role both in thylakoid biogenesis and chloroplast envelope maintenance during stress. Vipp1 is conserved in photosynthetic organisms and forms a high homo-oligomer complex structure that may help sustain the membrane integrity of chloroplasts. This study cloned two novel VIPP1 genes from Triticum...

A Novel Polar Copolymer Design as a Multi-Functional Binder for Strong Affinity of Polysulfides in Lithium-Sulfur Batteries

High energy density, low cost and environmental friendliness are the advantages of lithium-sulfur (Li-S) battery which is regarded as a promising device for electrochemical energy storage systems. As one of the important ingredients in Li-S battery, the binder greatly affects the battery performance. However, the conventional binder has some drawbacks such as poor capability of...

HER3, but Not HER4, Plays an Essential Role in the Clinicopathology and Prognosis of Gastric Cancer: A Meta-Analysis

Background and Aim Human epidermal growth factor receptor (HER) family plays an important role in gastric cancer (GC), especially HER2. Too much attention has been paid to HER2; however, the functions of HER3 and HER4 overexpression in GC are always ignored. The clinicopathological and prognostic roles of HER3 and HER4 in GC are controversial. In this study, a systematic review...

Efficacy differences of electroacupuncture with single acupoint or matching acupoints for chemotherapy-induced nausea and vomiting: study protocol for a randomized controlled trial

Previous studies have shown that acupuncture is beneficial for the alleviation of chemotherapy-induced nausea and vomiting. However, there is a lack of clinical evidence concerning the effects of acupoint-matching on chemotherapy-induced nausea and vomiting. This is a parallel randomized controlled trial to evaluate the occurrence of nausea and vomiting after chemotherapy (the...

Phosphorylated Mammalian Target of Rapamycin p-mTOR Is a Favorable Prognostic Factor than mTOR in Gastric Cancer

author's name, year of publication, total number of patients, clinicopathological parameters, and survival time. During the data extraction, any disagreements were resolved by a third investigator (Bo Chen

Clinicopathological Characteristics of Mucinous Breast Cancer: A Retrospective Analysis of a 10-Year Study

Background Mucinous breast carcinoma (MC) is a special type of breast cancer that presents with a large amount of extracellular mucin. MC comprises approximately 4% of all invasive breast cancers. This type of tumor has a better prognosis and higher incidence in peri- and post-menopausal patients. Pathologically, there are two main subtypes of MC: pure and mixed. In this study...