. Author Contributions Conceptualization: Genfeng Li, Bo Gao. Data curation: Genfeng Li, Cong Zhu. Formal analysis: Huaqiang Fang. Funding acquisition: Genfeng Li, Cong Zhu, Hao Hu. Investigation: Hao Hu ... . Methodology: Cong Zhu. Project administration: Genfeng Li. Supervision: Bo Gao. 12 / 13 14. 16. 17. Writing – original draft: Genfeng Li. Writing – review & editing: Bo Gao. Zhijun Zhou , Hao Wang, Yeqing
experiments and acquiring the data for this manuscript. Author Contributions Zhang, Qipeng Song. Conceptualization: Bo Gao, Li Li, Peixin Shen, Zhipeng Zhou, Peiming Xu, Wei Sun, Cui Data curation: Bo Gao ... , Zhipeng Zhou, Peiming Xu, Qipeng Song. Formal analysis: Bo Gao, Li Li, Qipeng Song. Investigation: Bo Gao, Peixin Shen. Methodology: Zhipeng Zhou, Wei Sun. Project administration: Bo Gao, Peixin Shen
(17YF1421800). Author Contributions Data curation: James A. Bunce, Xiaocen Zhu. Formal analysis: James A. Bunce, Xiaocen Zhu. Funding acquisition: James A. Bunce, Bo Gao. Investigation: Genyun Chen ... . Methodology: Mingnan Qu, Richard C. Sicher, Xiaocen Zhu. Project administration: James A. Bunce, Genyun Chen. 14 / 16 Resources: Richard C. Sicher, Bo Gao. Software: Mingnan Qu. Supervision: Richard C. Sicher
Stochastic link capacity degradations are common phenomena in transport network which can cause travel time variations and further can affect travelers’ daily route choice behaviors. This paper formulates a deterministic dynamic model, to capture the day-to-day (DTD) flow evolution process in the presence of degraded link capacity degradations. The aggregated network flow...
Casein kinase 1 delta (CK1δ) is a conserved serine/threonine protein kinase that regulates diverse cellular processes. Mice lacking CK1δ have a perinatal lethal phenotype and typically weigh 30% less than their wild type littermates. However, the causes of death and small size are unknown. We observed cells with abnormally large nuclei in tissue from Csnk1d null embryos, and...
conflicts of interest-Bo Gao. (PDF) Author Contributions Conceptualization: Bo Gao, Mark S. Shiroishi, Zhiqian Li, Guiquan Shen. Data curation: Bo Gao, Xudong Shen, Mark S. Shiroishi, Mingfan Pang, Zhiqian ... Li, Benxia Yu, Guiquan Shen. Formal analysis: Bo Gao, Xudong Shen, Mark S. Shiroishi, Zhiqian Li, Benxia Yu, Guiquan Shen. Funding acquisition: Bo Gao, Zhiqian Li, Guiquan Shen. Investigation: Bo
Background Tuberculosis (TB) represents a major global health problem. The prognosis of clinically active tuberculosis depends on the complex interactions between Mycobacterium tuberculosis (Mtb) and its host. In recent years, autophagy receives particular attention for its role in host defense against intracellular pathogens, including Mtb. In present study, we aim to...
Liver cirrhosis is recognized as being the consequence of immune-mediated hepatocyte damage and repair processes. However, the regulation of these immune responses underlying liver cirrhosis has not been elucidated. In this study, we used GEO datasets and bioinformatics methods to established coding and non-coding gene regulatory networks including transcription factor-/lncRNA...
Up to now, immunization of disease propagation has attracted great attention in both theoretical and experimental researches. However, vast majority of existing achievements are limited to the simple assumption of single layer networked population, which seems obviously inconsistent with recent development of complex network theory: each node could possess multiple roles in...
Supporting Information files. Funding: Harbin Medical University Postgraduate Innovative Research Projects, YJSCX2015-19HYD, Dr Bo Gao. The funders had no role in study design, data collection and analysis
Background It is well-recognized that diabetes represents a powerful independent risk factor for cardiovascular diseases. However, very few studies have investigated the relationship between diabetes and risk of aortic dissection (AD). Aim The aim of this case-control study was to evaluate the association between diabetes and risk of AD in Chinese population. Methods A hospital...
Objective The aim of this study was to compare the effects of hypotensive and normotensive resuscitation with a novel combination of fluids via lactate Ringer’s solution (LRS), 6% hydroxyethyl starch 130/0.4 solution (HES), and 7.5% hypertonic saline solution (HSS) at early stage of uncontrolled hemorrhagic shock (UHS) before hemostasis. Methods New Zealand white rabbits (n = 32...
Objective The aim of this study is to observe the chronic effects of diltiazem release capsules on patients with coronary slow flow (CSF) phenomenon. Methods From 2004 to 2009, 80 consecutive patients with chest pain and normal coronary arteries evidenced by coronary angiography and CSF were included in this randomized, double-blind, placebo-controlled trial. CSF patterns were...
Fungal diversity within plant roots is affected by several factors such as dispersal limitation, habitat filtering, and plant host preference. Given the differences in life style between symbiotic and non-symbiotic fungi, the main factors affecting these two groups of fungi may be different. We assessed the diversity of root associated fungi of Rhododendron decorum using internal...
The identification and quantitative analysis of protein-protein interactions are essential to the functional characterization of proteins in the post-proteomics era. The methods currently available are generally time-consuming, technically complicated, insensitive and/or semi-quantitative. The lack of simple, sensitive approaches to precisely quantify protein-protein interactions...
Odontogenesis relies on the reciprocal signaling interactions between dental epithelium and neural crest-derived mesenchyme, which is regulated by several signaling pathways. Subtle changes in the activity of these major signaling pathways can have dramatic effects on tooth development. An important regulator of such subtle changes is the fine tuning function of microRNAs (miRNAs...
Huang-Lian-Jie-Du Decoction (HLJDD) is a classical Traditional Chinese Medicine (TCM) formula with heat-dissipating and detoxifying effects. It is used to treat inflammation-associated diseases. However, no systematic pharmacokinetic (PK) and pharmacodynamic (PD) data concerning the activity of HLJDD under inflammatory conditions is available to date. In the present study, the...
The study of systems genetics is changing the way the genetic and molecular basis of phenotypic variation, such as disease susceptibility and drug response, is being analyzed. Moreover, systems genetics aids in the translation of insights from systems biology into genetics. The use of systems genetics enables greater attention to be focused on the potential impact of genetic...
Osteosarcoma, the most common primary bone tumor in children and young adolescents, is characterized by local invasion and distant metastasis. But the detailed mechanisms of osteosarcoma metastasis are not well known. In the present study, we found that βig-h3 promotes metastatic potential of human osteosarcoma cells in vitro and in vivo. Furthermore, βig-h3 co-localized with...
Fat infiltration within marrow cavity is one of multitudinous features of estrogen deficiency, which leads to a decline in bone formation functionality. The origin of this fat is unclear, but one possibility is that it is derived from osteoblasts, which transdifferentiate into adipocytes that produce bone marrow fat. We examined the dose-dependent effect of 17β-estradiol on the...
