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Identification of DNA-binding proteins using multi-features fusion and binary firefly optimization algorithm

Background DNA-binding proteins (DBPs) play fundamental roles in many biological processes. Therefore, the developing of effective computational tools for identifying DBPs is becoming highly desirable. Results In this study, we proposed an accurate method for the prediction of DBPs. Firstly, we focused on the challenge of improving DBP prediction accuracy with information solely...

R497K polymorphism in epidermal growth factor receptor gene is associated with the risk of acute coronary syndrome

Background Previous studies suggested that genetic polymorphisms in the epidermal growth factor receptor (EGFR) gene had been implicated in the susceptibility to some tumors and inflammatory diseases. EGFR has been recently implicated in vascular pathophysiological processes associated with excessive remodeling and atherosclerosis. Acute coronary syndrome (ACS) is a clinical...

Changes in Skeletal Muscle and Body Weight on Sleeping Beauty Transposon-Mediated Transgenic Mice Overexpressing Pig mIGF-1

Insulin-like growth factor (IGF-I) is an important growth factor in mammals, but the functions of the local muscle-specific isoform of insulin-like growth factor 1 (mIGF-1) to skeletal muscle development have rarely been reported. To determine the effect of pig mIGF-1 on body development and muscle deposition in vivo and to investigate the molecular mechanisms, the transgenic...

microRNA Expression in Rat Apical Periodontitis Bone Lesion

AuthorsSearch for Bo Gao in:Nature Research journals • PubMed • Google ScholarSearch for Liwei Zheng in:Nature Research journals • PubMed • Google Scholar Corresponding author Correspondence to Liwei Zheng

Severe burn injury in late pregnancy: a case report and literature review

The management of serious burn injuries during pregnancy is an unsolved clinical problem because of the low incidence of this disease. Although it has been documented that the effect of burns on fetal and maternal survival is detrimental, there have been conflicting reports among the different burn centers regarding the mortality of burned pregnant women and the management of...

Interleukin 23 regulates proliferation of lung cancer cells in a concentration-dependent way in association with the interleukin-23 receptor

A proinflammatory cytokine, interleukin 23 (IL-23), plays a role in tumor progression by inducing inflammation in the tumor microenvironment, although there is debate about its role in carcinogenesis. Direct effects of IL-23 on tumor cells have been reported rarely, and contradictory effects have been observed. Here, we studied such effects of IL-23 in lung cancer cells in vitro...

The association of interleukin-16 polymorphisms with IL-16 serum levels and risk of colorectal and gastric cancer

Interleukin (IL)-16, a multifunctional cytokine, plays a fundamental role in inflammatory diseases, as well as in the development and progression of tumors. Genetic variation in the DNA sequence of the IL-16 gene may lead to altered cytokine production and/or activity, and this variation may modulate an individual's susceptibility to both colorectal cancer (CRC) and gastric...

Missense mutations in IHH impair Indian Hedgehog signaling in C3H10T1/2 cells: Implications for brachydactyly type A1, and new targets for Hedgehog signaling

Heterozygous missense mutations in IHH result in Brachydactyly type A1 (BDA1; OMIM 112500), a condition characterized by the shortening of digits due to hypoplasia/aplasia of the middle phalanx. Indian Hedgehog signaling regulates the proliferation and differentiation of chondrocytes and is essential for endochondral bone formation. Analyses of activated IHH signaling in C3H10T1...

Static Force Analysis of Foot of Electrically Driven Heavy-Duty Six-Legged Robot under Tripod Gait

, China. He received his PhD degree from Harbin Institute of Technology, China, in 2015. His research interests include special robot systems and intelligent robotics. Hai-Bo Gao, born in 1970, is

Identification of citrullinated peptides in the synovial fluid of patients with rheumatoid arthritis using LC-MALDI-TOF/TOF

The objective of the study is to investigate potential citrullinated autoantigens as targets of anti-citrullinated protein antibodies (ACPAs) response in synovial fluids (SFs) of patients with rheumatoid arthritis (RA). SFs from six RA patients and six osteoarthritis (OA) patients as controls were collected. The citrullinated proteins in SFs were extracted by immunoprecipitation...

RhoA/Rho-Kinase Contribute to the Pathogenesis of Diabetic Renal Disease

Fangfang Peng Dongcheng Wu Bo Gao Alistair J. Ingram Baifang Zhang Katherine Chorneyko Rick McKenzie Joan C. Krepinsky OBJECTIVE-Accumulation of glomerular matrix proteins is central to the

Identification of Differentially Expressed Kinase and Screening Potential Anticancer Drugs in Papillary Thyroid Carcinoma

Aim. We aim to identify protein kinases involved in the pathophysiology of papillary thyroid carcinoma (PTC) in order to provide potential therapeutic targets for kinase inhibitors and unfold possible molecular mechanisms. Materials and Methods. The gene expression profile of GSE27155 was analyzed to identify differentially expressed genes and mapped onto human protein kinases...

Low diversity, activity, and density of transposable elements in five avian genomes

In this study, we conducted the activity, diversity, and density analysis of transposable elements (TEs) across five avian genomes (budgerigar, chicken, turkey, medium ground finch, and zebra finch) to explore the potential reason of small genome sizes of birds. We found that these avian genomes exhibited low density of TEs by about 10% of genome coverages and low diversity of...

Stress Analysis of a Class II MO-Restored Tooth Using a 3D CT-Based Finite Element Model

A computational method has been developed for stress analysis of a restored tooth so that experimental effort can be minimized. The objectives of this study include (i) developing a method to create a 3D FE assembly model for a restored tooth based on CT images and (ii) conducting stress analysis of the restored tooth using the 3D FE model established. To build up a solid...

Stress Analysis of a Class II MO-Restored Tooth Using a 3D CT-Based Finite Element Model

A computational method has been developed for stress analysis of a restored tooth so that experimental effort can be minimized. The objectives of this study include (i) developing a method to create a 3D FE assembly model for a restored tooth based on CT images and (ii) conducting stress analysis of the restored tooth using the 3D FE model established. To build up a solid...

Antibacterial activity and biological performance of a novel antibacterial coating containing a halogenated furanone compound loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium

Yicheng Cheng,1,2,* Xianghui Zhao,3,* Xianghui Liu,2,* Weige Sun,2 Huifang Ren,1 Bo Gao,1 Jiang Wu1 1State Key Laboratory of Military Stomatology, Department of Prosthodontics, School of Stomatology, Fourth

Tests of the Stability of Chinese RhFe Resistance Thermometers at Low Temperatures

Rhodium–iron resistance thermometers are recommended as precise thermometers at temperatures below 25 K. The thermometers were developed at the National Physical Laboratory and produced by H. Tinsley and Co Ltd almost 50 years ago. Later, they were made by other companies and institutes as well, but despite this, the availability of the thermometers decreased and a new source of...

ABCA Transporter Gene Expression and Poor Outcome in Epithelial Ovarian Cancer

Background ATP-binding cassette (ABC) transporters play various roles in cancer biology and drug resistance, but their association with outcomes in serous epithelial ovarian cancer (EOC) is unknown.