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A Randomized, Single-Center Double-Blinded Trial on the Effects of Diltiazem Sustained-Release Capsules in Patients with Coronary Slow Flow Phenomenon at 6-Month Follow-Up

Objective The aim of this study is to observe the chronic effects of diltiazem release capsules on patients with coronary slow flow (CSF) phenomenon. Methods From 2004 to 2009, 80 consecutive patients with chest pain and normal coronary arteries evidenced by coronary angiography and CSF were included in this randomized, double-blind, placebo-controlled trial. CSF patterns were...

A modified total arch replacement combined with a stented elephant trunk implantation for acute type A dissection under deep hypothermic circulatory arrest and selective antegrade cerebral perfusion

Objectives Since the optimal management of patients with acute aortic dissection is unclear, this study analyzed total arch replacement combined with stented elephant trunk implantation in the treatment of acute type A aortic dissection. Methods Between February 2008 and February 2013, 86 consecutive patients admitted to our hospital for acute type A dissection underwent total...

A multidimensional integration analysis reveals potential bridging targets in the process of colorectal cancer liver metastasis

Supporting Information files. Funding: Harbin Medical University Postgraduate Innovative Research Projects, YJSCX2015-19HYD, Dr Bo Gao. The funders had no role in study design, data collection and analysis

A pilot study of pre-operative motor dysfunction from gliomas in the region of corticospinal tract: Evaluation with diffusion tensor imaging

conflicts of interest-Bo Gao. (PDF) Author Contributions Conceptualization: Bo Gao, Mark S. Shiroishi, Zhiqian Li, Guiquan Shen. Data curation: Bo Gao, Xudong Shen, Mark S. Shiroishi, Mingfan Pang, Zhiqian ... Li, Benxia Yu, Guiquan Shen. Formal analysis: Bo Gao, Xudong Shen, Mark S. Shiroishi, Zhiqian Li, Benxia Yu, Guiquan Shen. Funding acquisition: Bo Gao, Zhiqian Li, Guiquan Shen. Investigation: Bo

ABCA Transporter Gene Expression and Poor Outcome in Epithelial Ovarian Cancer

Background ATP-binding cassette (ABC) transporters play various roles in cancer biology and drug resistance, but their association with outcomes in serous epithelial ovarian cancer (EOC) is unknown.

Allele-Specific Behavior of Molecular Networks: Understanding Small-Molecule Drug Response in Yeast

The study of systems genetics is changing the way the genetic and molecular basis of phenotypic variation, such as disease susceptibility and drug response, is being analyzed. Moreover, systems genetics aids in the translation of insights from systems biology into genetics. The use of systems genetics enables greater attention to be focused on the potential impact of genetic...

An attempt to interpret a biochemical mechanism of C4 photosynthetic thermo-tolerance under sudden heat shock on detached leaf in elevated CO2 grown maize

(17YF1421800). Author Contributions Data curation: James A. Bunce, Xiaocen Zhu. Formal analysis: James A. Bunce, Xiaocen Zhu. Funding acquisition: James A. Bunce, Bo Gao. Investigation: Genyun Chen ... . Methodology: Mingnan Qu, Richard C. Sicher, Xiaocen Zhu. Project administration: James A. Bunce, Genyun Chen. 14 / 16 Resources: Richard C. Sicher, Bo Gao. Software: Mingnan Qu. Supervision: Richard C. Sicher

Analysis on setting airshaft at mid-tunnel to reduce transient pressure variation

Setting airshaft is one of the methods efficient to control the aerodynamic effects on a train traveling through a tunnel. By using numeral simulation, analysis is carried out on the effect of airshaft on transient pressures generated in cabin. After setting airshaft, the magnitude of pressure fluctuation in cabin is reduced nearly 40%. By analyzing the role of airshaft in...

Antibacterial activity and biological performance of a novel antibacterial coating containing a halogenated furanone compound loaded poly(L-lactic acid) nanoparticles on microarc-oxidized titanium

Yicheng Cheng,1,2,* Xianghui Zhao,3,* Xianghui Liu,2,* Weige Sun,2 Huifang Ren,1 Bo Gao,1 Jiang Wu1 1State Key Laboratory of Military Stomatology, Department of Prosthodontics, School of Stomatology, Fourth

Association between Diabetes and Risk of Aortic Dissection: A Case-Control Study in a Chinese Population

Background It is well-recognized that diabetes represents a powerful independent risk factor for cardiovascular diseases. However, very few studies have investigated the relationship between diabetes and risk of aortic dissection (AD). Aim The aim of this case-control study was to evaluate the association between diabetes and risk of AD in Chinese population. Methods A hospital...

Changes in Skeletal Muscle and Body Weight on Sleeping Beauty Transposon-Mediated Transgenic Mice Overexpressing Pig mIGF-1

Insulin-like growth factor (IGF-I) is an important growth factor in mammals, but the functions of the local muscle-specific isoform of insulin-like growth factor 1 (mIGF-1) to skeletal muscle development have rarely been reported. To determine the effect of pig mIGF-1 on body development and muscle deposition in vivo and to investigate the molecular mechanisms, the transgenic...

Characteristics of Heavy Metals and Pb Isotopic Composition in Sediments Collected from the Tributaries in Three Gorges Reservoir, China

2013; Accepted 19 October 2013; Published 28 January 2014 Academic Editors: J. Lutzenkirchen and G. Sen Copyright © 2014 Bo Gao et al. This is an open access article distributed under the Creative

Coding and non-coding gene regulatory networks underlie the immune response in liver cirrhosis

Liver cirrhosis is recognized as being the consequence of immune-mediated hepatocyte damage and repair processes. However, the regulation of these immune responses underlying liver cirrhosis has not been elucidated. In this study, we used GEO datasets and bioinformatics methods to established coding and non-coding gene regulatory networks including transcription factor-/lncRNA...

Different Distribution Patterns between Putative Ercoid Mycorrhizal and Other Fungal Assemblages in Roots of Rhododendron decorum in the Southwest of China

Fungal diversity within plant roots is affected by several factors such as dispersal limitation, habitat filtering, and plant host preference. Given the differences in life style between symbiotic and non-symbiotic fungi, the main factors affecting these two groups of fungi may be different. We assessed the diversity of root associated fungi of Rhododendron decorum using internal...

Dose-Dependent Effect of Estrogen Suppresses the Osteo-Adipogenic Transdifferentiation of Osteoblasts via Canonical Wnt Signaling Pathway

Fat infiltration within marrow cavity is one of multitudinous features of estrogen deficiency, which leads to a decline in bone formation functionality. The origin of this fat is unclear, but one possibility is that it is derived from osteoblasts, which transdifferentiate into adipocytes that produce bone marrow fat. We examined the dose-dependent effect of 17β-estradiol on the...

Effect of Hypotensive Resuscitation with a Novel Combination of Fluids in a Rabbit Model of Uncontrolled Hemorrhagic Shock

Objective The aim of this study was to compare the effects of hypotensive and normotensive resuscitation with a novel combination of fluids via lactate Ringer’s solution (LRS), 6% hydroxyethyl starch 130/0.4 solution (HES), and 7.5% hypertonic saline solution (HSS) at early stage of uncontrolled hemorrhagic shock (UHS) before hemostasis. Methods New Zealand white rabbits (n = 32...

Evolution of Photoluminescence, Raman, and Structure of CH3NH3PbI3 Perovskite Microwires Under Humidity Exposure

Self-assembled organic-inorganic CH3NH3PbI3 perovskite microwires (MWs) upon humidity exposure along several weeks were investigated by photoluminescence (PL) spectroscopy, Raman spectroscopy, and X-ray diffraction (XRD). We show that, in addition to the common perovskite decomposition into PbI2 and the formation of a hydrated phase, humidity induced a gradual PL redshift at the...

Exploiting noise in array CGH data to improve detection of DNA copy number change

2122412883; Fax: +1 2128492643; Email: *Correspondence may also be addressed to Jian-Bo Gao. Tel: +1 3523920918; Fax: +1 3523920044; Email: - Developing effective methods for analyzing arrayCGH data to