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Optimal economic operation of isolated community microgrid incorporating temperature controlling devices

With the increasing connection of controllable devices to isolated community microgrid, an economic operation model of isolated community microgrid based on the temperature regulation characteristics of temperature controlling devices composed of wind turbine, micro-gas turbine, energy storage battery and heat pump is proposed. With full consideration of various economic costs...

Mycoalgae biofilm: development of a novel platform technology using algae and fungal cultures

Background Microalgae is considered a promising source for biofuel and bioenergy production, bio-remediation and production of high-value bioactive compounds, but harvesting microalgae is a major bottleneck in the algae based processes. The objective of this research is to mimic the growth of natural lichen and develop a novel biofilm platform technology using filamentous fungi...

Determining the optimal screening interval for type 2 diabetes mellitus using a risk prediction model

Kou, Anita D. Misra-Hebert, Bo Hu. Formal analysis: Andrei Brateanu, Lei Kou, Bo Hu. Funding acquisition: Andrei Brateanu, Nana Kobaivanova. Investigation: Andrei Brateanu, Sihe Wang. Methodology ... : Andrei Brateanu, Anita D. Misra-Hebert, Bo Hu, Abhishek Deshpande, Nana Kobaivanova, Michael B. Rothberg. Project administration: Andrei Brateanu, Sihe Wang. Resources: Andrei Brateanu, Sihe Wang, Nana

Transurethral 160-W straight beam green laser vaporesection of the prostate: initial experience after 180 procedures

Although the photoselective vaporization of the prostate has been considered one of the most promising alternatives for treatment of benign prostatic hyperplasia (BPH), published clinical data with the surgical technology of straight beam lithium triborate laser (LBO) is still lacking. To evaluate the technical improvement and initial experience of the 160-W straight beam LBO...

Behaviors and Strategies of Bacterial Navigation in Chemical and Nonchemical Gradients

Navigation of cells to the optimal environmental condition is critical for their survival and growth. Escherichia coli cells, for example, can detect various chemicals and move up or down those chemical gradients (i.e., chemotaxis). Using the same signaling machinery, they can also sense other external factors such as pH and temperature and navigate from both sides toward some...

Wind speed model based on kernel density estimation and its application in reliability assessment of generating systems

. IEEE Trans Power Appar Syst PAS-102 ( 1 ): 134 -143 Bo HU received the Ph.D. degree in electrical engineering from Chongqing University, Chongqing, China, in 2010 . Currently, he is an associate

MethylAction: detecting differentially methylated regions that distinguish biological subtypes

DNA methylation differences capture substantial information about the molecular and gene-regulatory states among biological subtypes. Enrichment-based next generation sequencing methods such as MBD-isolated genome sequencing (MiGS) and MeDIP-seq are appealing for studying DNA methylation genome-wide in order to distinguish between biological subtypes. However, current analytic...

Metabolic engineering of Methylobacterium extorquens AM1 for 1-butanol production

Background Butanol is a promising next generation fuel and a bulk chemical precursor. Although clostridia are the primary industrial microbes for the fermentative production of 1-butanol, alternative engineered hosts have the potential to generate 1-butanol from alternative carbon feedstocks via synthetic metabolic pathways. Methylobacterium extorquens AM1, a facultative...

Mitochondrial Haplogroups and Risk of Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is a serious and often fatal disease. It is a panvasculopathy of the pulmonary microcirculation characterized by vasoconstriction and arterial obstruction due to vascular proliferation and remodeling and ultimately right ventricular failure. Mitochondrial dysfunction is a universal finding in pulmonary vascular cells of patients with PAH, and...

Metabolomics Revealed an Association of Metabolite Changes and Defective Growth in Methylobacterium extorquens AM1 Overexpressing ecm during Growth on Methanol

Methylobacterium extorquens AM1 is a facultative methylotroph capable of growth on both single-carbon and multi-carbon compounds. The ethylmalonyl-CoA (EMC) pathway is one of the central assimilatory pathways in M. extorquens during growth on C1 and C2 substrates. Previous studies had shown that ethylmalonyl-CoA mutase functioned as a control point during the transition from...

Terminal sliding mode control for cyber physical system based on filtering backstepping

Based on a nonlinear flight dynamic model with aerodynamic coefficients and external disturbance uncertainties, which is a typical cyber physical system, a filtering backstepping terminal sliding mode control method is proposed for a robust controller. The tracking differentiator can provide the capability of solving the problem of “complexity explosion” in backstepping...

Financial Incentives and Diabetes Disease Control in Employees: A Retrospective Cohort Analysis

Collaborative of Cleveland (grant KL2TR000440) and the National Center for Advancing Translational Sciences. Author Contributions: Drs. Anita D. Misra-Hebert, Bo Hu, Glen Taksler, and Michael B. Rothberg had ... access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Dr. Bo Hu, Department of Quantitative Health Sciences, Cleveland Clinic

Development of a Peptide ELISA for the Diagnosis of Aleutian Mink Disease

Aleutian disease (AD) is a common immunosuppressive disease in mink farms world-wide. Since the 1980s, counterimmunoelectrophoresis (CIEP) has been the main detection method for infection with the Aleutian Mink Disease Virus (AMDV). In this study, six peptides derived from the AMDV structural protein VP2 were designed, synthesized, and used as ELISA antigens to detect anti-AMDV...

Association of AT1R polymorphism with hypertension risk: An update meta-analysis based on 28,952 subjects

Background: Previous studies have shown that angiotensin II AT1 receptor gene (AT1R) polymorphisms are associated with the risk for hypertension. However, the results remain controversial. In the present study, we performed a meta-analysis to systematically summarize the association between AT1R genetic polymorphisms and the risk for hypertension.

Comprehensive molecular characterization of Methylobacterium extorquens AM1 adapted for 1-butanol tolerance

Background The toxicity of alcohols is one of the major roadblocks of biological fermentation for biofuels production. Methylobacterium extorquens AM1, a facultative methylotrophic α-proteobacterium, has been engineered to generate 1-butanol from cheap carbon feedstocks through a synthetic metabolic pathway. However, M. extorquens AM1 is vulnerable to solvent stress, which...

Identification and Evaluation of Reference Genes for Accurate Transcription Normalization in Safflower under Different Experimental Conditions

Safflower (Carthamus tinctorius L.) has received a significant amount of attention as a medicinal plant and oilseed crop. Gene expression studies provide a theoretical molecular biology foundation for improving new traits and developing new cultivars. Real-time quantitative PCR (RT-qPCR) has become a crucial approach for gene expression analysis. In addition, appropriate...

Cell-cell junctions: a target of acoustic overstimulation in the sensory epithelium of the cochlea

BackgroundExposure to intense noise causes the excessive movement of the organ of Corti, stretching the organ and compromising sensory cell functions. We recently revealed changes in the transcriptional expression of multiple adhesion-related genes during the acute phases of cochlear damage, suggesting that the disruption of cell-cell junctions is an early event in the process of...

Identifying Driver Genomic Alterations in Cancers by Searching Minimum-Weight, Mutually Exclusive Sets

An important goal of cancer genomic research is to identify the driving pathways underlying disease mechanisms and the heterogeneity of cancers. It is well known that somatic genome alterations (SGAs) affecting the genes that encode the proteins within a common signaling pathway exhibit mutual exclusivity, in which these SGAs usually do not co-occur in a tumor. With some success...

Effects of Psychological Stress on Hypertension in Middle-Aged Chinese: A Cross-Sectional Study

We examined the effect and relative contributions of different types of stress on the risk of hypertension. Using cluster sampling, 5,976 community-dwelling individuals aged 40–60 were selected. Hypertension was defined according to the Seventh Report of the Joint National Committee, and general psychological stress was defined as experiencing stress at work or home. Information...