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Three new species of Paraboea (Gesneriaceae) from limestone karsts of China based on morphological and molecular evidence

13008 (IBK); ibid., 20 March 2013, Bo Pan & Chun-Rui Lin H2159 (IBK); ibid., 20 March 2013, Quanzhou Exped. 450324130320003LY (IBK). Hunan: Yongzhou City, Shiyantou Town, 250 m, 20 March 2013, Bo Pan et ... broadly cuneate), the cymes, 2–3-branched, 6–22-flowered (vs. 1–2-branched, 3–8-flowered). Type: CHINA. Guangxi: Quanzhou County, Huangshahe Town. 240  m, 26°03′N, 111°13′E, 20 March 2013, Wei-Bin Xu & Bo

Inhibition of histone acetylation by curcumin reduces alcohol-induced fetal cardiac apoptosis

Background Prenatal alcohol exposure may cause cardiac development defects, however, the underlying mechanisms are not yet clear. In the present study we have investigated the roles of histone modification by curcumin on alcohol induced fetal cardiac abnormalities during the development. Methods and results Q-PCR and Western blot results showed that alcohol exposure increased...

Optimization and preoperative adjustment design of remote center motion mechanism for minimally invasive surgical robot

In this paper, a new remote center motion (RCM) mechanism called triangle is proposed; this mechanism is simple and with high stiffness. A complete kinematic analysis and optimization algorithm implying AHP which is a combination of quantitative and qualitative analysis method incorporating the requirements for minimally invasive surgery (MIS) are performed to find the optimal...

Diagnostic Accuracy of PIK3CA Mutation Detection by Circulating Free DNA in Breast Cancer: A Meta-Analysis of Diagnostic Test Accuracy

Mutation of p110 alpha-catalytic subunit of phosphatidylinositol 3-kinase (PIK3CA) has high predictive and prognostic values for breast cancer. Hence, there has been a marked interest in detecting and monitoring PIK3CA genotype with non-invasive technique, such as circulating free DNA (cfDNA). However, the diagnostic accuracy of PIK3CA genotyping by cfDNA is still a problem of...

Three new species of Primulina (Gesneriaceae) from limestone karsts of China based on morphological and molecular evidence

specific epithet is derived from the white maculation along the veins. Additional specimens examined CHINA. Guangdong Province, Yangchun City, Shiwang Township, 11 April 2014, Wei-Bin Xu & Bo Pan 11949 (IBK ... Province, Yangshan County, Qinglian Township, alt. 60 m, in the crevice of limestone hills, 3 May 2012, Bo Pan & Wei-Bin Xu 11697 (holotype IBK). Primulina yangshanensis is most similar to P. mabaensis K.F

DNA methylation regulates mouse cardiac myofibril gene expression during heart development

Background It is well known that epigenetic modifications play an important role in controlling the regulation of gene expression during the development. Our previous studies have demonstrated that the expression of fetal troponin I gene (also called slow skeletal troponin I, ssTnI) is predominated in the fetal stage, reduced after birth and disappeared in the adulthood. The...

Unique Effects of Acute Aripiprazole Treatment on the Dopamine D2 Receptor Downstream cAMP-PKA and Akt-GSK3β Signalling Pathways in Rats

Aripiprazole is a wide-used antipsychotic drug with therapeutic effects on both positive and negative symptoms of schizophrenia, and reduced side-effects. Although aripiprazole was developed as a dopamine D2 receptor (D2R) partial agonist, all other D2R partial agonists that aimed to mimic aripiprazole failed to exert therapeutic effects in clinic. The present in vivo study aimed...

One-layer versus two-layer duct-to-mucosa pancreaticojejunostomy after pancreaticoduodenectomy: study protocol for a randomized controlled trial

Background Although various pancreaticojejunal duct-to-mucosa anastomosis methods have been developed to reduce the postoperative risks of pancreaticoduodenectomy, pancreatic fistula remains the most serious complication with a high incident rate. The aim of this study is to compare the safety and effectiveness of one-layer and two-layer duct-to-mucosa pancreaticojejunostomy in...

Dexamethasone versus ondansetron in the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgery: a meta-analysis of randomized controlled trials

Background Dexamethasone is an antiemetic alternative to ondansetron. We aimed to compare the effects of dexamethasone and ondansetron in preventing postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic surgery. Methods We searched PubMed, Embase, Medline and Cochrane Library (from inception to July 2014) for eligible studies. The primary outcome was the...

Understanding the molecular mechanisms of human microtia via a pig model of HOXA1 syndrome

Microtia is a congenital malformation of the outer ears. Although both genetic and environmental components have been implicated in microtia, the genetic causes of this innate disorder are poorly understood. Pigs have naturally occurring diseases comparable to those in humans, providing exceptional opportunity to dissect the molecular mechanism of human inherited diseases. Here...

Organic contaminants and carbon nanoparticles: sorption mechanisms and impact parameters

Bo PAN 0 0 (Faculty of Environmental Science & Engineering, Kunming University of Science & Technology , Kunming 650500 , China) 1 Project supported by the National Natural Science Foundation of China

Fibroblast Activation Protein Overexpression and Clinical Implications in Solid Tumors: A Meta-Analysis

Objective Fibroblast activation protein (FAP) plays a vital role in tumor invasion and metastasis. Previous studies have reported its prognostic value in different tumors. However, the results of these reports remain controversial. In this study, a meta-analysis was performed to clarify this issue. Methods A search of the PubMed, Embase and CNKI databases was conducted to analyze...

Islet-1 May Function as an Assistant Factor for Histone Acetylation and Regulation of Cardiac Development-Related Transcription Factor Mef2c Expression

ObjectiveIslet-1 is an important transcription factor for cardiac development through mediating extensive interactions between DNA and proteins. The present study was to investigate the role of Islet-1 in regulating the expression of cardiac development-related transcription factors and mechanism. Methods and ResultsThe expression of Islet-1 and histone acetylases (HATs) subtype...

PaGenBase: A Pattern Gene Database for the Global and Dynamic Understanding of Gene Function

Pattern genes are a group of genes that have a modularized expression behavior under serial physiological conditions. The identification of pattern genes will provide a path toward a global and dynamic understanding of gene functions and their roles in particular biological processes or events, such as development and pathogenesis. In this study, we present PaGenBase, a novel...

PaGeFinder: quantitative identification of spatiotemporal pattern genes

Summary: Pattern Gene Finder (PaGeFinder) is a web-based server for on-line detection of gene expression patterns from serial transcriptomic data generated by high-throughput technologies like microarray or next-generation sequencing. Three particular parameters, the specificity measure, the dispersion measure and the contribution measure, were introduced and implemented in...

DNA methylation of germ-cell-specific basic helix-loop-helix (HLH) transcription factors, Sohlh2 and Figlα during gametogenesis

Regulation of germ-cell-specific transcription is essential for the differentiation and other physiological processes of germ cells. Germ-cell-specific transcription factors, Sohlh2 and Figla, play key roles in gametogenesis. To elucidate whether an epigenetic mechanism is involved in the controlled expression of Sohlh2 and Figlα, we examined the dynamics of DNA methylation at...

Indications of Clinical and Genetic Predictors for Aromatase Inhibitors Related Musculoskeletal Adverse Events in Chinese Han Women with Breast Cancer

Background Women with breast cancer treated with aromatase inhibitors (AIs) may experience musculoskeletal symptoms that lead to discontinuation of effective therapy. The purpose of the current study is to evaluate the clinical and genetic predictors for AIs-related musculoskeletal adverse events(MS-AEs). Methodology and Principal Findings We recruited 436 postmenopausal Chinese...