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Sodium channel Nav1.7 expression is upregulated in the dorsal root ganglia in a rat model of paclitaxel-induced peripheral neuropathy

Paclitaxel-induced peripheral neuropathy is not completely known. Since the sodium channel Nav1.7 has been implicated in pain perception, and is upregulated in pain disorders, we investigated the effect of paclitaxel on Nav1.7 expression in rat dorsal root ganglion (DRG) neurons. Thirty Sprague-Dawley rats were administered either 2 mg/kg paclitaxel or vehicle on days 0, 2, 4 and ...

Precise film dosimetry for stereotactic radiosurgery and stereotactic body radiotherapy quality assurance using Gafchromic™ EBT3 films

Purpose The purpose of this study is to evaluate the dosimetric uncertainty associated with Gafchromic™ (EBT3) films and establish a practical and efficient film dosimetry protocol for Stereotactic Radiosurgery (SRS) and Stereotactic Body Radiotherapy (SBRT). Method and materials EBT3 films were irradiated at each of seven different dose levels between 1 and 15 Gy with open fields ...

To gate or not to gate - dosimetric evaluation comparing Gated vs. ITV-based methodologies in stereotactic ablative body radiotherapy (SABR) treatment of lung cancer

Background To compare retrospectively generated gated plans to conventional internal target volume (ITV)-based plans and to evaluate whether gated radiotherapy provides clinically relevant dosimetric improvements to organs-at-risk (OARs). Methods Evaluation was performed of 150 stereotactic ablative radiotherapy treatment plans delivered to 128 early-stage (T1-T3 (<5 cm)) NSCLC ...

Acausality in nonlocal gravity theory

We investigate the nonlocal gravity theory by deriving nonlocal equations of motion using the traditional variation principle in a homogeneous background. We focus on a class of models with a linear nonlocal modification term in the action. It is found that the resulting equations of motion contain the advanced Green’s function, implying that there is an acausality problem. As a ...

Positive effect of HPV status on prognostic value of blood lymphocyte-to-monocyte ratio in advanced cervical carcinoma

Background This retrospective study aimed to investigate the prognostic significance of pretreatment lymphocyte-to-monocyte ratio (LMR) in locally advanced cervical cancer and its effect on overall survival. Methods The usual blood routine test was quantitatively performed to detect LMR. Signal strengths of human papilloma virus (HPV) type DNA in detected cervical cancer samples ...

Determining leaf trajectories for dynamic multileaf collimators with consideration of marker visibility: an algorithm study

The purpose of this study was to develop a leaf-setting algorithm for Dynamic Multileaf Collimator–Intensity-Modulated Radiation Therapy (DMLC–IMRT) for optimal marker visibility. Here, a leaf-setting algorithm (called a Delta algorithm) was developed with the objective of maximizing marker visibility so as to improve the tracking effectiveness of fiducial markers during treatment ...

A Computationally Inexpensive Optimal Guidance via Radial-Basis-Function Neural Network for Autonomous Soft Landing on Asteroids

Optimal guidance is essential for the soft landing task. However, due to its high computational complexities, it is hardly applied to the autonomous guidance. In this paper, a computationally inexpensive optimal guidance algorithm based on the radial basis function neural network (RBFNN) is proposed. The optimization problem of the trajectory for soft landing on asteroids is ...

sRNATarBase 3.0: an updated database for sRNA-target interactions in bacteria

Bacterial sRNAs are a class of small regulatory RNAs of about 40–500 nt in length; they play multiple biological roles through binding to their target mRNAs or proteins. Therefore, elucidating sRNA targets is very important. However, only targets of a few sRNAs have been described. To facilitate sRNA functional studies such as developing sRNA target prediction models, we updated ...

Decentralized Sliding Mode Observer Based Dual Closed-Loop Fault Tolerant Control for Reconfigurable Manipulator against Actuator Failure

This paper considers a decentralized fault tolerant control (DFTC) scheme for reconfigurable manipulators. With the appearance of norm-bounded failure, a dual closed-loop trajectory tracking control algorithm is proposed on the basis of the Lyapunov stability theory. Characterized by the modularization property, the actuator failure is estimated by the proposed decentralized ...

mRNA translation and protein synthesis: an analysis of different modelling methodologies and a new PBN based approach

Background mRNA translation involves simultaneous movement of multiple ribosomes on the mRNA and is also subject to regulatory mechanisms at different stages. Translation can be described by various codon-based models, including ODE, TASEP, and Petri net models. Although such models have been extensively used, the overlap and differences between these models and the implications of ...

Retraction Note to: Genetic polymorphisms in VDR, ESR1 and ESR2 genes may contribute to susceptibility to Parkinson’s disease: a meta-analysis

& Li-Bo Zhao The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publica tion Ethics (COPE). After a thorough investigation we have strong reason to

Energetic cost of behavioral thermoregulation in turtle embryos

The cost of behavioral thermoregulation is well recognized in the posthatching stage of ectothermic vertebrates. However, thermoregulatory behavior was discovered only recently in turtle embryos, and the cost of this interesting behavior remains unknown. We manipulated the intensity of thermoregulatory behavior in turtle embryos (Pelodiscus sinensis) and determined the hatching ...

Effects of vagus nerve stimulation on cognitive functioning in rats with cerebral ischemia reperfusion

Background Vagus nerve stimulation (VNS) has become the most common non-pharmacological treatment for intractable drug-resistant epilepsy. However, the contribution of VNS to neurological rehabilitation following stroke has not been thoroughly examined. Therefore, we investigated the specific role of acute VNS in the recovery of cognitive functioning and the possible mechanisms ...

Effects of Manipulated Above- and Belowground Organic Matter Input on Soil Respiration in a Chinese Pine Plantation

Alteration in the amount of soil organic matter input can have profound effect on carbon dynamics in forest soils. The objective of our research was to determine the response in soil respiration to above- and belowground organic matter manipulation in a Chinese pine (Pinus tabulaeformis) plantation. Five organic matter treatments were applied during a 2-year experiment: both litter ...

Temporal Coordination of Carbohydrate Metabolism during Mosquito Reproduction

Hematophagous mosquitoes serve as vectors of multiple devastating human diseases, and many unique physiological features contribute to the incredible evolutionary success of these insects. These functions place high-energy demands on a reproducing female mosquito, and carbohydrate metabolism (CM) must be synchronized with these needs. Functional analysis of metabolic gene profiling ...

Regulation of Gene Expression Patterns in Mosquito Reproduction

In multicellular organisms, development, growth and reproduction require coordinated expression of numerous functional and regulatory genes. Insects, in addition to being the most speciose animal group with enormous biological and economical significance, represent outstanding model organisms for studying regulation of synchronized gene expression due to their rapid development and ...

DNA Detection of Schistosoma japonicum: Diagnostic Validity of a LAMP Assay for Low-Intensity Infection and Effects of Chemotherapy in Humans

Background Schistosomiasis has decreased significantly in prevalence and intensity of infection in China, thus more accurate and sensitive methods are desperately needed for the further control of schistosomiasis. The present work aimed to assess the utility of the loop-mediated isothermal amplification (LAMP) for detection of light intensity infection or false-negative patients ...

Small Peptide Inhibitor of JNK3 Protects Dopaminergic Neurons from MPTP Induced Injury via Inhibiting the ASK1-JNK3 Signaling Pathway

Introduction and Aims The ASK1-JNK3 signaling pathway plays a pivotal role in the pathogenesis of Parkinson's disease (PD). The specific binding of β-arrestin2 to JNK3 is essential for activation of the ASK1-JNK3 cascade, representing a potential therapeutic target for preventing dopaminergic neuronal death in PD. The aim of this study was to identify a novel strategy for the ...

Overexpression of NIMA-related kinase 2 is associated with progression and poor prognosis of prostate cancer

Background The NIMA-related kinase 2 (NEK2) is a serine/threonine kinase that is involved in regulation of centrosome duplication and spindle assembly during mitosis. Dysregulation of these processes causes chromosome instability and aneuploidy, which are hallmark changes of many solid tumors. However, whether aberrant expression of NEK2 is associated with outcome of prostate ...

Turtle embryos move to optimal thermal environments within the egg

Bo Zhao Teng Li Richard Shine Wei-Guo Du 0 School of Biological Sciences A08, University of Sydney , New South Wales 2006 Australia 1 Hangzhou Key Laboratory of Animal Adaptation and Evolution