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Search: authors:"Bradley R. Groveman"

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Prion protein cleavage fragments regulate adult neural stem cell quiescence through redox modulation of mitochondrial fission and SOD2 expression

Neurogenesis continues in the post-developmental brain throughout life. The ability to stimulate the production of new neurones requires both quiescent and actively proliferating pools of neural stem cells (NSCs). Actively proliferating NSCs ensure that neurogenic demand can be met, whilst the quiescent pool makes certain NSC reserves do not become depleted. The processes...

Hippocampal protein kinase D1 is necessary for DHPG-induced learning and memory impairments in rats

. Conceptualization: Wenkuan Xin, Michael W. Salter, Mohamed Kabbaj, Xian-Min Yu. Data curation: Wei Wang, Florian Duclot, Bradley R. Groveman, Hui Wang. Formal analysis: Wei Wang, Florian Duclot, Bradley R. Groveman ... , Xin-Sheng Ding, Mohamed Kabbaj, Xian-Min Yu. Funding acquisition: Xing-Hong Jiang, Xin-Sheng Ding, Xian-Min Yu. Investigation: Wei Wang, Florian Duclot, Bradley R. Groveman, Nicole Carrier, Xiao-Qian

Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains

Prions propagate as multiple strains in a wide variety of mammalian species. The detection of all such strains by a single ultrasensitive assay such as Real Time Quaking-induced Conversion (RT-QuIC) would facilitate prion disease diagnosis, surveillance and research. Previous studies have shown that bank voles, and transgenic mice expressing bank vole prion protein, are...