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Search: authors:"Bram J. van Raam"

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Caspase Cleavage Sites in the Human Proteome: CaspDB, a Database of Predicted Substrates

Bram J. van Raam 0 Guy S. Salvesen 0 Piotr Cieplak 0 Shawn B. Bratton, The University of Texas MD Anderson Cancer Center, United States of America 0 Sanford Burnham Medical Research Institute , La Jolla

Mitochondrial Membrane Potential in Human Neutrophils Is Maintained by Complex III Activity in the Absence of Supercomplex Organisation

BackgroundNeutrophils depend mainly on glycolysis for their energy provision. Their mitochondria maintain a membrane potential (Δψm), which is usually generated by the respiratory chain complexes. We investigated the source of Δψm in neutrophils, as compared to peripheral blood mononuclear leukocytes and HL-60 cells, and whether neutrophils can still utilise this Δψm for the...