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A Study of Coronary Bifurcation Shape in a Normal Population

During percutaneous coronary intervention, stents are placed in narrowings of the arteries to restore normal blood flow. Despite improvements in stent design, deployment techniques and drug-eluting coatings, restenosis and stent thrombosis remain a significant problem. Population stent design based on statistical shape analysis may improve clinical outcomes. Computed tomographic ...

Real-time aortic pulse wave velocity measurement during exercise stress testing

Background Pulse wave velocity (PWV), a measure of arterial stiffness, has been demonstrated to be an independent predictor of adverse cardiovascular outcomes. This can be derived non-invasively using cardiovascular magnetic resonance (CMR). Changes in PWV during exercise may reveal further information on vascular pathology. However, most known CMR methods for quantifying PWV are ...

Information maximizing component analysis of left ventricular remodeling due to myocardial infarction

Background Although adverse left ventricular shape changes (remodeling) after myocardial infarction (MI) are predictive of morbidity and mortality, current clinical assessment is limited to simple mass and volume measures, or dimension ratios such as length to width ratio. We hypothesized that information maximizing component analysis (IMCA), a supervised feature extraction method, ...

Hemodynamics in Idealized Stented Coronary Arteries: Important Stent Design Considerations

Stent induced hemodynamic changes in the coronary arteries are associated with higher risk of adverse clinical outcome. The purpose of this study was to evaluate the impact of stent design on wall shear stress (WSS), time average WSS, and WSS gradient (WSSG), in idealized stent geometries using computational fluid dynamics. Strut spacing, thickness, luminal protrusion, and ...

Quantification of LV function and mass by cardiovascular magnetic resonance: multi-center variability and consensus contours

Background High reproducibility of LV mass and volume measurement from cine cardiovascular magnetic resonance (CMR) has been shown within single centers. However, the extent to which contours may vary from center to center, due to different training protocols, is unknown. We aimed to quantify sources of variation between many centers, and provide a multi-center consensus ground ...

1099 Fully automated segmentation of the left and right ventricles: validation with a large clinical trial

Xiang Lin 0 Brett Cowan 0 Alistair Young 0 0 Address: University of Auckland , Auckland , New Zealand - Introduction Segmentation of the left (LV) and right (RV) ventricles is required for clinical