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Diagnostic yield and therapeutic impact of open lung biopsy in the critically ill patient

patients. (DOCX) Acknowledgments We thank M. Watts for his help with translation into English. Author Contributions Conceptualization: Bertrand Souweine. Formal analysis: Lucie Cassagnes, Bruno Pereira

Heart rate variability in type 2 diabetes mellitus: A systematic review and meta–analysis

suitability was not reached, a third author (Bruno Pereira) reviewed the debated articles. Then, all authors reviewed the eligible articles. 3 / 19 Quality of the assessment Despite not designed for ... analysis: Bruno Pereira, FreÂdeÂric Dutheil. Investigation: Thomas Benichou, FreÂdeÂric Dutheil. Methodology: FreÂdeÂric Dutheil. Project administration: FreÂdeÂric Dutheil. Resources: Thomas Benichou

Effects of flow rate on the migration of different plasticizers from PVC infusion medical devices

Auvergne); Gael Grimandi, Pierre Pinta (LIOAD UMR 791, University of Nantes, France), Colette Breysse (3S InPack, Aubière, France) Author Contributions Conceptualization: Lise Bernard, Bruno Pereira ... , ValeÂrie Sautou. Data curation: Lise Bernard, ValeÂrie Sautou. Formal analysis: Teuta Eljezi, HeÂlène Clauson, CeÂline Lambert, Bruno Pereira. Investigation: Teuta Eljezi, HeÂlène Clauson. Methodology

Effect of ketamine combined with magnesium sulfate in neuropathic pain patients (KETAPAIN): study protocol for a randomized controlled trial

Neuropathic pain is difficult to treat, and the efficacy of recommended drugs remains limited. N-methyl-d-aspartate receptors are implicated, and antagonists are a pharmacological option. Ketamine is widely used in French pain clinics, but without consensus or recommendations. Furthermore, the association of ketamine with magnesium has been poorly studied. The aim of the present...

Decreased prevalence of cancer in patients with multiple sclerosis: A case-control study

and controls. Author Contributions Taithe, Pierre Clavelou. Conceptualization: Xavier Moisset, Maud PerieÂ, Bruno Pereira, Emilie Dumont, Frederic Data curation: Xavier Moisset, Maud PerieÂ, Emilie ... Dumont, FrancËois-Xavier Lesage, Frederic Dutheil, Frederic Taithe, Pierre Clavelou. Formal analysis: Bruno Pereira. Funding acquisition: Pierre Clavelou. Investigation: Xavier Moisset, Maud PerieÂ

Randomized blinded trial of standardized written patient information before total knee arthroplasty

Background The effect of patient education before total knee arthroplasty (TKA) is controversial. No consensus exists about the optimal content of educational interventions. In a previous study, we developed and validated an educational booklet on the peri-TKA management of knee osteoarthritis. Purposes Our primary purpose was to evaluate the impact of the educational booklet on...

Burnout, associated comorbidities and coping strategies in French community pharmacies—BOP study: A nationwide cross-sectional study

Background Work-related stress and burnout syndromes are unfortunately common comorbidities found in health professionals. However, burnout syndrome has only been partly and episodically assessed for community pharmacists whereas these professionals are exposed to patients’ demands and difficulties every day. Prevalence of burnout, associated comorbidities and coping strategies...

At-risk and intervention thresholds of occupational stress using a visual analogue scale

Background The visual analogue scale (VAS) is widely used in clinical practice by occupational physicians to assess perceived stress in workers. However, a single cut-off (black-or-white decision) inadequately discriminates between workers with and without stress. We explored an innovative statistical approach to distinguish an at-risk population among stressed workers, and to...

Stress and salivary cortisol in emergency medical dispatchers: A randomized shifts control trial

Stress at work is a public health concern. Phone operators in emergency medical dispatch centers are particularly at risk. We aimed to demonstrate that the most stressful time for emergency medical dispatchers is the shift when they receive emergency incoming calls, with cortisol as a biomarker of stress. For each emergency medical dispatcher, we measured outcomes over a control...

Oxidative and Anti-Oxidative Stress Markers in Chronic Glaucoma: A Systematic Review and Meta-Analysis

Chronic glaucoma is a multifactorial disease among which oxidative stress may play a major pathophysiological role. We conducted a systematic review and meta-analysis to evaluate the levels of oxidative and antioxidative stress markers in chronic glaucoma compared with a control group. The PubMed, Cochrane Library, Embase and Science Direct databases were searched for studies...

Incidence of immediate postpartum hemorrhages in French maternity units: a prospective observational study (HERA study)

Background Most estimates of postpartum hemorrhage (PPH) are calculated from studies that use administrative or medical birth databases, and only a few from prospective observational studies. Our principal objective was to estimate the incidence of PPH according to their severity (mild or severe) in vaginal deliveries (>500 mL, ≥1000 mL) and cesareans (>1000 mL and ≥1500 mL). The...

Vascular endothelial growth factor levels and rheumatic diseases of the elderly

Bruno Pereira 5 Marc Andre 0 3 Martin Soubrier 4 0 Département de médecine interne, Centre Hospitalier Universitaire Gabriel Montpied , 58, rue Montalembert, 63000 Clermont-Ferrand , France 1

Antibioprophylaxis in Prevention of Endophthalmitis in Intravitreal Injection: A Systematic Review and Meta-Analysis

Despite endophthalmitis being the most feared complication, antibioprophylaxis remains controversial in intravitreal injections. Therefore, we conducted a systematic review and meta-analysis on the effects of antibioprophylaxis in intravitreal injections in the prevention of endophthalmitis. The PubMed, Cochrane Library, Embase and Science Direct databases were searched for...

Fibromyalgia, milnacipran and experimental pain modulation: study protocol for a double blind randomized controlled trial

Background The prevalence of fibromyalgia increases worldwide and is characterized by widespread and chronic pain. Treatment is difficult and includes both drug and non-drug approaches. Milnacipran, an antidepressant, is used for fibromyalgia, with a possible beneficial effect on central pain modulation. Our hypothesis is that the efficacy of milnacipran in fibromyalgia depends...

Memantine before Mastectomy Prevents Post-Surgery Pain: A Randomized, Blinded Clinical Trial in Surgical Patients

Background Neuropathic pain following surgical treatment for breast cancer with or without chemotherapy is a clinical burden and patients frequently report cognitive, emotional and quality of life impairment. A preclinical study recently showed that memantine administered before surgery may prevent neuropathic pain development and cognitive dysfunction. With a translational...

General Practitioners’ Barriers to Prescribe Physical Activity: The Dark Side of the Cluster Effects on the Physical Activity of Their Type 2 Diabetes Patients

Aims/hypothesis To describe barriers to physical activity (PA) in type 2 diabetes patients and their general practitioners (GPs), looking for practitioner’s influence on PA practice of their patients. Methods We conducted a cross-sectional study on GPs (n = 48) and their type 2 diabetes patients (n = 369) measuring respectively barriers to prescribe and practice PA using a self...

Impact of patient education on chronic heart failure in primary care (ETIC): a cluster randomised trial

Background The Education Thérapeutique des patients Insuffisants Cardiaques (ETIC; Therapeutic Education for Patients with Cardiac Failure) trial aimed to determine whether a pragmatic education intervention in general practice could improve the quality of life of patients with chronic heart failure (CHF) compared with routine care. Results This cluster randomised controlled...

Daily urinary urea excretion to guide intermittent hemodialysis weaning in critically ill patients

Background There are no easily available markers of renal recovery to guide intermittent hemodialysis (IHD) weaning. The aim of this study was to identify markers for IHD weaning in critically ill patients with acute kidney injury (AKI). Methods We performed a retrospective single-center cohort study of patients treated with IHD for at least 7 days and four dialysis sessions for...