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Oxidative toxicity in diabetes and Alzheimer’s disease: mechanisms behind ROS/ RNS generation

of Biological Sciences, University of Queensland, Australia. Bushra Ijaz is Assistant professor at CEMB, University of the Punjab, Lahore, Sidra Rehman is Assistant professor at COMSATS; while Fayyaz

Gene expression profiling of HCV genotype 3a initial liver fibrosis and cirrhosis patients using microarray

Background Hepatitis C virus (HCV) causes liver fibrosis that may lead to liver cirrhosis or hepatocellular carcinoma (HCC), and may partially depend on infecting viral genotype. HCV genotype 3a is being more common in Asian population, especially Pakistan; the detail mechanism of infection still needs to be explored. In this study, we investigated and compared the gene...

Role of HCV Core gene of genotype 1a and 3a and host gene Cox-2 in HCV-induced pathogenesis

manuscript. Authors’ information Shah Jahan (PhD molecular Biology) and Saba Khaliq (PhD molecular Biology) are both PhD scholars, Bushra Ijaz (M Phil Molecular Biology) and Waqar Ahmad (M Phil Chemistry) are

Anti-apoptotic effect of HCV core gene of genotype 3a in Huh-7 cell line

Molecular Biology), Saba Khaliq (PhD Molecular Biology), Usman Ali Ashfaq (PhD Molecular Biology), Muhammad Hassan Siddiqui (M. Phil Molecular Biology) and Bushra Ijaz and Waqar Ahmad are research officer at

Revised cutoff values of ALT and HBV DNA level can better differentiate HBeAg (-) chronic inactive HBV patients from active carriers

. All work was performed under supervision of SH. We all authors read and approved the final manuscript. Authors information Bushra Ijaz (M Phil Molecular Biology), Waqar Ahmad (M Phil Chemistry) and

Development of persistent HCV genotype 3a infection cell culture model in huh-7 cell

Background Hepatitis C virus (HCV) is one of the major health concerns globally, with genotype 3a as the most prevalent in Pakistan. Lack of efficient HCV genotype 3a small animal models as well as genomic replicons has hampered the complete understanding of its life cycle, pathogenesis and therapeutic options. In this study we aimed to develop a persistent HCV genotype 3a...

HCV entry receptors as potential targets for siRNA-based inhibition of HCV

Background Hepatitis C virus (HCV) is a major health concern with almost 3% of the world's population (350 million individuals) and 10% of the Pakistani population chronically infected with this viral pathogen. The current therapy of interferon-α and ribavirin against HCV has limited efficiency, so alternative options are desperately needed. RNA interference (RNAi), which results...

Huh-7 cell line as an alternative cultural model for the production of human like erythropoietin (EPO)

Background and Aims Erythropoietin (EPO) is a glycoprotein hormone which is required to regulate the production of red blood cells. Deficiency of EPO is known to cause anemia in chronically infected renal patients and they require regular blood transfusion. Availability of recombinant EPO has eliminated the need for blood transfusion and now it is extensively used for the...

Effect of combined siRNA of HCV E2 gene and HCV receptors against HCV

Molecular Biolohgy) and Usman Ali Ashfaq (PhD Molecular Biology) are research scholars at CEMB. Bushra Ijaz (M.Phil Molecular Biology) and Waqar Ahmad (M.Phil Chemistry) are research officers at CEMB whereas

HCV genotype-specific correlation with serum markers: Higher predictability for genotype 4a

Background Several factors have been proposed to assess the clinical outcome of HCV infection. The correlation of HCV genotypes to possible serum markers in clinical prediction is still controversial. The main objective of this study was to determine the existence of any correlation between HCV genotypes to viral load and different clinical serum markers. Methods We performed a...

Inhibition of core gene of HCV 3a genotype using synthetic and vector derived siRNAs

, Bushra Ijaz (M Phil Molecular Biology) and Waqar Ahmad (M Phil Chemistry) are Research Officer, Sultan Asad, Asim Pervaiz, Baila Samreen and Mahwish Khan are M Phil scholars, while Sajida Hassan (PhD

Association of laboratory parameters with viral factors in patients with hepatitis C

. Authors information Bushra Ijaz (M Phil Molecular Biology), Waqar Ahmad (M Phil Chemistry) and Gull S (MSc Biochemistry) are Research Officer; Shah Jahan and Saba Khaliq (PhD in Molecular biology), Javed FT

NS4A protein as a marker of HCV history suggests that different HCV genotypes originally evolved from genotype 1b

the final manuscript. Authors information Bushra Ijaz (M Phil Molecular Biology), Waqar Ahmad (M Phil Chemistry), and Sana Gull (MSc Biochemistry) are Research Officer at CEMB. Aleena Samrin and Usman

Claudin-1 required for HCV virus entry has high potential for phosphorylation and O-glycosylation

the final manuscript. Authors information Bushra Ijaz (M Phil Molecular Biology), Waqar Ahmad (M Phil Chemistry) and Gull S (MSc Biochemistry) are Research Officer; Shabbiri K is lecturer while Fouzia

Serine 204 phosphorylation and O-β-GlcNAC interplay of IGFBP-6 as therapeutic indicator to regulate IGF-II functions in viral mediated hepatocellular carcinoma

, IB, SK, IB and HS approve finalized version of paper. All work was performed under supervision of HS. All authors read and approved the final manuscript. Authors information Bushra Ijaz (M Phil

A comparison of four fibrosis indexes in chronic HCV: Development of new fibrosis-cirrhosis index (FCI)

arrange data. All work was performed under supervision of SH. All authors read and approved the final manuscript. Authors information Bushra Ijaz (M Phil Molecular Biology), Waqar Ahmad (M Phil Chemistry

A brief review on molecular, genetic and imaging techniques for HCV fibrosis evaluation

performed under supervision of HS. All authors read and approved the final manuscript. Authors information Shah Jahan, Saba Khaliq and Samrin A (PhD in Molecular biology), Bushra Ijaz (M Phil Molecular