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Search: authors:"Cátia Monteiro"

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Epigenome-wide DNA methylation profiling of periprostatic adipose tissue in prostate cancer patients with excess adiposity—a pilot study

Monteiro 0 8 Andreia Matos 6 7 Jiaying You 2 Avelino Fraga 5 6 Carina Pereira 0 10 Victoria Catalán 4 9 Amaia Rodríguez 4 9 Javier Gómez-Ambrosi 4 9 Gema Frühbeck 4 9 12 Pingzh 0 Molecular Oncology Group

Matrix metalloproteases as maestros for the dual role of LPS- and IL-10-stimulated macrophages in cancer cell behaviour

Background The interactions established between macrophages and cancer cells are largely dependent on instructions from the tumour microenvironment. Macrophages may differentiate into populations with distinct inflammatory profiles, but knowledge on their role on cancer cell activities is still very scarce. In this work, we investigated the influence of pro-inflammatory (LPS...

Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro

Background Obesity is associated with prostate cancer aggressiveness and mortality. The contribution of periprostatic adipose tissue, which is often infiltrated by malignant cells, to cancer progression is largely unknown. Thus, this study aimed to determine if periprostatic adipose tissue is linked with aggressive tumor biology in prostate cancer. Methods Supernatants of whole...

Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue

Background Periprostatic (PP) adipose tissue surrounds the prostate, an organ with a high predisposition to become malignant. Frequently, growing prostatic tumor cells extend beyond the prostatic organ towards this fat depot. This study aimed to determine the genome-wide expression of genes in PP adipose tissue in obesity/overweight (OB/OW) and prostate cancer patients. Methods...