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Mild cognitive impairment is associated with poor physical function but not bone structure or density in late adulthood: findings from the Hertfordshire cohort study

A. Patel is first author. C. Cooper and E.M. Dennison are joint senior authors. Introduction Mild cognitive impairment (MCI) is a heterogeneous state between normal ageing and early dementia [ 1 ... Research UK and the International Osteoporosis Foundation. Compliance with ethical standards Conflict of interest Professor C Cooper has received consultancy fees/ honoraria from Servier; Eli Lilly; Merck

Muscle Mass, Muscle Morphology and Bone Health Among Community-Dwelling Older Men: Findings from the Hertfordshire Sarcopenia Study (HSS)

Sarcopenia and osteoporosis are associated with poor health outcomes in older people. Relationships between muscle and bone have typically been reported at a functional or macroscopic level. The aims of this study were to describe the relationships between muscle morphology and bone health among participants of the Hertfordshire Sarcopenia Study (HSS). 105 older men, mean age 72...

Correlates of Level and Loss of Grip Strength in Later Life: Findings from the English Longitudinal Study of Ageing and the Hertfordshire Cohort Study

contributed equally to the manuscript. C. Cooper and C. R. Gale are senior authors and contributed equally to the manuscript characterised using mixed-effects models in ELSA and a residual change approach in ... accountable for the work. Compliance with Ethical Standards Conflict of interest H. E. Syddall, L. D. Westbury, S. C. Shaw, E. M. Dennison, C. Cooper, and C. R. Gale declare that they have no conflict of

A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence

. Skidmore, Khairul Mohd Fadzli Mustaffa, Lynsay C. Cooper, Scott E. Guimond, Edwin A. Yates, Alister G. Craig. Funding acquisition: Mark A. Skidmore, Edwin A. Yates, Alister G. Craig. Investigation: Khairul ... Mohd Fadzli Mustaffa, Lynsay C. Cooper, Scott E. Guimond. Methodology: Mark A. Skidmore, Lynsay C. Cooper, Scott E. Guimond, Alister G. Craig. 14 / 16 Project administration: Edwin A. Yates, Alister G

Epidemiology of Sarcopenia: Determinants Throughout the Lifecourse

Sarcopenia is an age-related syndrome characterised by progressive and generalised loss of skeletal muscle mass and strength; it is a major contributor to the risk of physical frailty, functional impairment in older people, poor health-related quality of life and premature death. Many different definitions have been used to describe sarcopenia and have resulted in varying...

Bone Phenotype Assessed by HRpQCT and Associations with Fracture Risk in the GLOW Study

they have no conflict of interest. C Cooper reports personal fees from Alliance for Better Bone Health, Amgen, Eli Lilly, GSK, Medtronic, Merck, Novartis, Pfizer, Roche, Servier, Takeda and UCB

Relationships Between Markers of Inflammation and Muscle Mass, Strength and Function: Findings from the Hertfordshire Cohort Study

and C. Cooper declare that they have no conflict of interest. Ethical Approval The baseline Hertfordshire Cohort Study had ethical approval from the Hertfordshire and Bedfordshire Local Research Ethics

Recent hip fracture trends in Sweden and Denmark with age-period-cohort effects

Summary This study used nationwide hip fracture data from Denmark and Sweden during 1987–2010 to examine effects of (birth) cohort and period. We found that time trends, cohort, and period effects were different in the two countries. Results also indicated that hip fracture rates may increase in the not so far future. Introduction The reasons for the downturn in hip fracture...

Bone density and body composition in newly licenced professional jockeys

Summary The primary objective is the description of bone mineral density (BMD) and body composition in newly licensed jockeys. One in three male, flat jockeys has a very low bone mineral density. Further research is needed to assess the short-term risk of fractures and long-term health implications of these findings. Introduction Describe bone mineral density (BMD) and body...

Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review

Summary This systematic review summarizes the effect of combined exercise and nutrition intervention on muscle mass and muscle function. A total of 37 RCTs were identified. Results indicate that physical exercise has a positive impact on muscle mass and muscle function in subjects aged 65 years and older. However, any interactive effect of dietary supplementation appears to be...

Physical activity and osteoarthritis: a consensus study to harmonise self-reporting methods of physical activity across international cohorts

for Sport, Exercise and Osteoarthritis (Grant Ref. 20194). Conflict of interest B Ainsworth receives royalties from Taylor & Francis. C Cooper has received consultancy from Servier, Amgen, Novartis, Eli

Secondary prevention of fractures after hip fracture: a qualitative study of effective service delivery

Summary There is variation in how services to prevent secondary fractures after hip fracture are delivered and no consensus on best models of care. This study identifies healthcare professionals’ views on effective care for the prevention of these fractures. It is hoped this will provide information on how to develop services. Introduction Hip fracture patients are at high risk...

Skeletal muscle morphology in sarcopenia defined using the EWGSOP criteria: findings from the Hertfordshire Sarcopenia Study (HSS)

Background Sarcopenia is defined as the loss of muscle mass and function with age and is associated with decline in mobility, frailty, falls and mortality. There is considerable interest in understanding the underlying mechanisms. Our aim was to characterise muscle morphology changes associated with sarcopenia among community dwelling older men. Methods One hundred and five men...

Identification and management of patients at increased risk of osteoporotic fracture: outcomes of an ESCEO expert consensus meeting

Summary Osteoporosis represents a significant and increasing healthcare burden in Europe, but most patients at increased risk of fracture do not receive medication, resulting in a large treatment gap. Identification of patients who are at particularly high risk will help clinicians target appropriate treatment more precisely and cost-effectively, and should be the focus of future...

UK clinical guideline for the prevention and treatment of osteoporosis

50 years in the UK . Maturitas 62 : 105 - 108 4. Compston J , Bowring C , Cooper A , Cooper C , Davies C , Francis R , Kanis JA , Marsh D , McCloskey EV , Reid DM , Selby P , National Osteoporosis

Life-course approach to nutrition

Alliance ( 2014 ) Fracture Prevention Central . http://www.nbha.org/fpc Accessed 8 Jun 2015 Akesson K, Marsh D , Mitchell PJ , McLellan AR , Stenmark J , Pierroz DD , Kyer C , Cooper C , Group IOFFW ( 2013

The RUDY study platform – a novel approach to patient driven research in rare musculoskeletal diseases

Background Research into rare diseases is becoming more common, with recognition of the significant diagnostic and therapeutic care gaps. Registries are considered a key research methodology to address rare diseases. This report describes the structure of the Rare UK Diseases Study (RUDY) platform that aims to improve research processes and address many of the challenges of...

A novel accelerometer-based method to describe day-to-day exposure to potentially osteogenic vertical impacts in older adults: findings from a multi-cohort study

Summary This observational study assessed vertical impacts experienced in older adults as part of their day-to-day physical activity using accelerometry and questionnaire data. Population-based older adults experienced very limited high-impact activity. The accelerometry method utilised appeared to be valid based on comparisons between different cohorts and with self-reported...