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52 papers found.
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Anti-Neu5Gc and anti-non-Neu5Gc antibodies in healthy humans

Our group previously investigated the levels of anti-Gal and anti-nonGal IgM and IgG in a cohort of 75 healthy humans of various backgrounds, and found some significant differences related to factors such as age, gender, ABO blood group, diet, vaccination history, and geographic location during childhood. We have now expanded our cohort (n = 84) to investigate the levels of ...

Programmable type III-A CRISPR-Cas DNA targeting modules

The CRISPR-Cas systems provide invader defense in a wide variety of prokaryotes, as well as technologies for many powerful applications. The Type III-A or Csm CRISPR-Cas system is one of the most widely distributed across prokaryotic phyla, and cleaves targeted DNA and RNA molecules. In this work, we have constructed modules of Csm systems from 3 bacterial species and ...

Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review

Summary This systematic review summarizes the effect of combined exercise and nutrition intervention on muscle mass and muscle function. A total of 37 RCTs were identified. Results indicate that physical exercise has a positive impact on muscle mass and muscle function in subjects aged 65 years and older. However, any interactive effect of dietary supplementation appears to be ...

Physical activity and osteoarthritis: a consensus study to harmonise self-reporting methods of physical activity across international cohorts

for Sport, Exercise and Osteoarthritis (Grant Ref. 20194). Conflict of interest B Ainsworth receives royalties from Taylor & Francis. C Cooper has received consultancy from Servier, Amgen, Novartis, Eli

The RUDY study platform – a novel approach to patient driven research in rare musculoskeletal diseases

Background Research into rare diseases is becoming more common, with recognition of the significant diagnostic and therapeutic care gaps. Registries are considered a key research methodology to address rare diseases. This report describes the structure of the Rare UK Diseases Study (RUDY) platform that aims to improve research processes and address many of the challenges of ...

Life-course approach to nutrition

Alliance ( 2014 ) Fracture Prevention Central . Accessed 8 Jun 2015 Akesson K, Marsh D , Mitchell PJ , McLellan AR , Stenmark J , Pierroz DD , Kyer C , Cooper C , Group IOFFW ( 2013

The Role of the Posterior Temporal and Medial Prefrontal Cortices in Mediating Learning from Romantic Interest and Rejection

Romantic interest or rejection can be powerful incentives not merely for their emotional impact, but for their potential to transform, in a single interaction, what we think we know about another person—or ourselves. Little is known, though, about how the brain computes expectations for, and learns from, real-world romantic signals. In a novel “speed-dating” paradigm, we had ...

The unfolded protein response is required for dendrite morphogenesis

Taylor, Roshni C Cooper, Kang Shen Xing Wei, Audrey S Howell, Xintong Dong, Caitlin A Taylor, Roshni C Cooper, Kang Shen The funders had no role in study design, data collection and interpretation, or the ... . the python code for image processing and data analysis. DOI: 10.7554/eLife.06963.025 5R01NS082208-02 Xing Wei, Audrey S Howell, Xintong Dong , Caitlin A Taylor, Roshni C Cooper, Kang Shen Arakawa

Effect of Roux-en-Y Gastric Bypass Surgery on Bile Acid Metabolism in Normal and Obese Diabetic Rats

In addition to classic functions of facilitating hepatobiliary secretion and intestinal absorption of lipophilic nutrients, bile acids (BA) are also endocrine factors and regulate glucose and lipid metabolism. Recent data indicate that antiobesity bariatric procedures e.g. Roux-en-Y gastric bypass surgery (RYGB), which also remit diabetes, increase plasma BAs in humans, leading to ...

Behavioral economics: implications for regulatory behavior

James C. Cooper 0 William E. Kovacic 0 0 J. C. Cooper Law & Economics Center, George Mason University School of Law , Arlington, VA, USA Behavioral economics (BE) examines the implications for

Lack of Modulation of Nicotinic Acetylcholine Alpha-7 Receptor Currents by Kynurenic Acid in Adult Hippocampal Interneurons

Kynurenic acid (KYNA), a classical ionotropic glutamate receptor antagonist is also purported to block the α7-subtype nicotinic acetylcholine receptor (α7* nAChR). Although many published studies cite this potential effect, few have studied it directly. In this study, the α7*-selective agonist, choline, was pressure-applied to interneurons in hippocampal subregions, CA1 stratum ...

Post-traumatic Stress Disorder, Race/Ethnicity, and Coronary Artery Disease Among Older Patients with Depression

, VA Palo Alto Health Care System , Palo Alto, CA , USA 1 D. C. Cooper 2 HSR&D, VA Puget Sound Health Care System , 1100 Olive Way, Suite 1400, Seattle, WA 98101 , USA 3 D. C. Cooper ( 4 K. M. Nelson 5 R

Ion Channel Expression in the Developing Enteric Nervous System

The enteric nervous system arises from neural crest-derived cells (ENCCs) that migrate caudally along the embryonic gut. The expression of ion channels by ENCCs in embryonic mice was investigated using a PCR-based array, RT-PCR and immunohistochemistry. Many ion channels, including chloride, calcium, potassium and sodium channels were already expressed by ENCCs at E11.5. There was ...

The US FRAX® filter: avoiding confusion or hindering progress?

Briefing , July 2003 2 ) Academic Unit of Bone Metabolism, University of Sheffield , Sheffield S5 7AU, UK 3 C. Cooper MRC Epidemiology Resource Centre, University of Southampton , Southampton, UK - The

Switch therapy in hospitalized patients with community-acquired pneumonia: Tigecycline vs. Levofloxacin

Background Switch therapy is a management approach combining early discontinuation of intravenous (IV) antibiotics, switch to oral antibiotics, and early hospital discharge. This analysis compares switch therapy using tigecycline versus levofloxacin in hospitalized patients with community-acquired pneumonia (CAP). Methods A prospective, randomized, double-blind, Phase 3 clinical ...

Xenotransplantation—will tolerance be essential?

that might induce tolerance. David K. C. Cooper Advance Access publication 5 August 2006 Sir, We appreciate Coopers opinion, which is based on a large experience in the field. Undoubtedly, major progress

Galaxy assembly bias on the red sequence

M. C. Cooper et al. 0 Department of Physics and Astronomy, University of Pittsburgh , 401-C Allen Hall, 3941 O'Hara Street, Pittsburgh, PA 15260, USA 1 Max-Planck-Institut fur Astronomie , Konigstuhl

Erratum to: Management of osteoporosis of the oldest old

, London , UK 8 A. Diez-Perez Servicio de Medicina Interna y Enfermedades Infecciosas, Hospital del Mar-IMIM and RETICEF , Barcelona , Spain 9 C. Cooper NIHR Musculoskeletal Biomedical Research Unit

The Arizona CDFS Environment Survey (ACES): A Magellan/IMACS Spectroscopic Survey of the Chandra Deep Field-South⋆

We present the Arizona CDFS Environment Survey (ACES), a recently completed spectroscopic redshift survey of the Chandra Deep Field-South (CDFS) conducted using the Inamori-Magellan Areal Camera and Spectrograph on the Magellan-Baade telescope. In total, the survey targeted 7277 unique sources down to a limiting magnitude of RAB = 24.1, yielding 5080 secure redshifts across the ∼30 ...