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Search: authors:"C. Cooper"

4 papers found.
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Metabolic aspects of pig-to-monkey (Macaca fascicularis) islet transplantation: implications for translation into clinical practice

A. Casu R. Bottino A. N. Balamurugan H. Hara D. J. van der Windt N. Campanile C. Smetanka D. K. C. Cooper M. Trucco Aims/hypothesis Attempts to use an alternative source of islets to restore glucose

PARL Leu262Val is not associated with fasting insulin levels in UK populations

Aims/hypothesis PARL, the gene encoding presenilins-associated rhomboid-like protein, maps to chromosome 3q27 within a quantitative trait locus that influences components of the metabolic syndrome. Recently, an amino acid substitution (Leu262Val, rs3732581) in PARL was associated with fasting plasma insulin levels in a US white population (N=1031). This variant was also found to...

Type 2 diabetes mellitus is associated with increased axial bone density in men and women from the Hertfordshire Cohort Study: evidence for an indirect effect of insulin resistance?

Aims/hypothesis Previous studies have suggested that the high bone density often observed in type 2 diabetic patients may be explained by insulin resistance. We explored this hypothesis in the Hertfordshire Cohort Study. Methods A total of 465 men and 444 women aged 59 to 71 years and with no prior diagnosis of diabetes attended a clinic where a glucose tolerance test was...

The effects of aerobic exercise on metabolic risk, insulin sensitivity and intrahepatic lipid in healthy older people from the Hertfordshire Cohort Study: a randomised controlled trial

Aims/hypothesis We sought to determine the effect of an aerobic exercise intervention on clustered metabolic risk and related outcomes in healthy older adults in a single-centre, explanatory randomised controlled trial. Methods Participants from the Hertfordshire Cohort Study (born 1931–1939) were randomly assigned to 36 supervised 1 h sessions on a cycle ergometer over 12 weeks...