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Xenotransplantation—will tolerance be essential?

that might induce tolerance. David K. C. Cooper Advance Access publication 5 August 2006 Sir, We appreciate Coopers opinion, which is based on a large experience in the field. Undoubtedly, major progress

Erythropoietin resistance: the role of inflammation and pro‐inflammatory cytokines

Up to 10% of patients with renal disease receiving recombinant human erythropoietin (rHuEPO) therapy show poor responsiveness to the drug. Even in patients who do respond to rHuEPO, there is a marked variability in drug sensitivity. Several factors have been recognized as causing resistance to rHuEPO, notably iron deficiency, infection/inflammation, and underdialysis. However...

Poor response to recombinant erythropoietin is associated with loss of T‐lymphocyte CD28 expression and altered interleukin‐10 production

Background. Recombinant erythropoietin (Epo) therapy is well established as an effective treatment for the anaemia of end‐stage renal disease. However, 5–10% of such patients do not respond adequately and an important contributory factor to this is chronic inflammation. Methods. The present study compares the circulating T‐cell phenotypes of haemodialysis patients who respond...