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141 papers found.
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Mild cognitive impairment is associated with poor physical function but not bone structure or density in late adulthood: findings from the Hertfordshire cohort study

A. Patel is first author. C. Cooper and E.M. Dennison are joint senior authors. Introduction Mild cognitive impairment (MCI) is a heterogeneous state between normal ageing and early dementia [ 1 ... Research UK and the International Osteoporosis Foundation. Compliance with ethical standards Conflict of interest Professor C Cooper has received consultancy fees/ honoraria from Servier; Eli Lilly; Merck

Muscle Mass, Muscle Morphology and Bone Health Among Community-Dwelling Older Men: Findings from the Hertfordshire Sarcopenia Study (HSS)

Sarcopenia and osteoporosis are associated with poor health outcomes in older people. Relationships between muscle and bone have typically been reported at a functional or macroscopic level. The aims of this study were to describe the relationships between muscle morphology and bone health among participants of the Hertfordshire Sarcopenia Study (HSS). 105 older men, mean age 72...

Personal exposure to fine particulate air pollution while commuting: An examination of six transport modes on an urban arterial roadway

, Chantel D. Sloan, Victoria C. Cooper, Daniel R. Robinson, James D. Johnston. Formal analysis: Chantel D. Sloan, Victoria C. Cooper, Daniel R. Robinson, James D. Johnston. 12 / 15 Funding acquisition ... . Sloan. Supervision: Robert A. Chaney, James D. Johnston. Validation: Chantel D. Sloan. Visualization: Chantel D. Sloan. Writing ± original draft: Robert A. Chaney, Chantel D. Sloan, Victoria C. Cooper

Relationships Between Markers of Inflammation and Muscle Mass, Strength and Function: Findings from the Hertfordshire Cohort Study

and C. Cooper declare that they have no conflict of interest. Ethical Approval The baseline Hertfordshire Cohort Study had ethical approval from the Hertfordshire and Bedfordshire Local Research Ethics

Correlates of Level and Loss of Grip Strength in Later Life: Findings from the English Longitudinal Study of Ageing and the Hertfordshire Cohort Study

contributed equally to the manuscript. C. Cooper and C. R. Gale are senior authors and contributed equally to the manuscript characterised using mixed-effects models in ELSA and a residual change approach in ... accountable for the work. Compliance with Ethical Standards Conflict of interest H. E. Syddall, L. D. Westbury, S. C. Shaw, E. M. Dennison, C. Cooper, and C. R. Gale declare that they have no conflict of

A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence

. Skidmore, Khairul Mohd Fadzli Mustaffa, Lynsay C. Cooper, Scott E. Guimond, Edwin A. Yates, Alister G. Craig. Funding acquisition: Mark A. Skidmore, Edwin A. Yates, Alister G. Craig. Investigation: Khairul ... Mohd Fadzli Mustaffa, Lynsay C. Cooper, Scott E. Guimond. Methodology: Mark A. Skidmore, Lynsay C. Cooper, Scott E. Guimond, Alister G. Craig. 14 / 16 Project administration: Edwin A. Yates, Alister G

Bone Phenotype Assessed by HRpQCT and Associations with Fracture Risk in the GLOW Study

they have no conflict of interest. C Cooper reports personal fees from Alliance for Better Bone Health, Amgen, Eli Lilly, GSK, Medtronic, Merck, Novartis, Pfizer, Roche, Servier, Takeda and UCB

Anti-Neu5Gc and anti-non-Neu5Gc antibodies in healthy humans

Our group previously investigated the levels of anti-Gal and anti-nonGal IgM and IgG in a cohort of 75 healthy humans of various backgrounds, and found some significant differences related to factors such as age, gender, ABO blood group, diet, vaccination history, and geographic location during childhood. We have now expanded our cohort (n = 84) to investigate the levels of anti...

Bone density and body composition in newly licenced professional jockeys

Summary The primary objective is the description of bone mineral density (BMD) and body composition in newly licensed jockeys. One in three male, flat jockeys has a very low bone mineral density. Further research is needed to assess the short-term risk of fractures and long-term health implications of these findings. Introduction Describe bone mineral density (BMD) and body...

Identification and management of patients at increased risk of osteoporotic fracture: outcomes of an ESCEO expert consensus meeting

Summary Osteoporosis represents a significant and increasing healthcare burden in Europe, but most patients at increased risk of fracture do not receive medication, resulting in a large treatment gap. Identification of patients who are at particularly high risk will help clinicians target appropriate treatment more precisely and cost-effectively, and should be the focus of future...

Programmable type III-A CRISPR-Cas DNA targeting modules

The CRISPR-Cas systems provide invader defense in a wide variety of prokaryotes, as well as technologies for many powerful applications. The Type III-A or Csm CRISPR-Cas system is one of the most widely distributed across prokaryotic phyla, and cleaves targeted DNA and RNA molecules. In this work, we have constructed modules of Csm systems from 3 bacterial species and...

UK clinical guideline for the prevention and treatment of osteoporosis

50 years in the UK . Maturitas 62 : 105 - 108 4. Compston J , Bowring C , Cooper A , Cooper C , Davies C , Francis R , Kanis JA , Marsh D , McCloskey EV , Reid DM , Selby P , National Osteoporosis

Epidemiology of Sarcopenia: Determinants Throughout the Lifecourse

Sarcopenia is an age-related syndrome characterised by progressive and generalised loss of skeletal muscle mass and strength; it is a major contributor to the risk of physical frailty, functional impairment in older people, poor health-related quality of life and premature death. Many different definitions have been used to describe sarcopenia and have resulted in varying...

Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review

Summary This systematic review summarizes the effect of combined exercise and nutrition intervention on muscle mass and muscle function. A total of 37 RCTs were identified. Results indicate that physical exercise has a positive impact on muscle mass and muscle function in subjects aged 65 years and older. However, any interactive effect of dietary supplementation appears to be...

Physical activity and osteoarthritis: a consensus study to harmonise self-reporting methods of physical activity across international cohorts

for Sport, Exercise and Osteoarthritis (Grant Ref. 20194). Conflict of interest B Ainsworth receives royalties from Taylor & Francis. C Cooper has received consultancy from Servier, Amgen, Novartis, Eli

A longitudinal cohort study of HIV ‘treatment as prevention’ in gay, bisexual and other men who have sex with men: the Treatment with Antiretrovirals and their Impact on Positive And Negative men (TAIPAN) study protocol

Background Australia has increased coverage of antiretroviral treatment (ART) over the past decade, reaching 73% uptake in 2014. While ART reduces AIDS-related deaths, accumulating evidence suggests that it could also bolster prevention efforts by reducing the risk of HIV transmission (‘treatment as prevention’). While promising, evidence of community-level impact of treatment as...

The RUDY study platform – a novel approach to patient driven research in rare musculoskeletal diseases

Background Research into rare diseases is becoming more common, with recognition of the significant diagnostic and therapeutic care gaps. Registries are considered a key research methodology to address rare diseases. This report describes the structure of the Rare UK Diseases Study (RUDY) platform that aims to improve research processes and address many of the challenges of...

A novel accelerometer-based method to describe day-to-day exposure to potentially osteogenic vertical impacts in older adults: findings from a multi-cohort study

Summary This observational study assessed vertical impacts experienced in older adults as part of their day-to-day physical activity using accelerometry and questionnaire data. Population-based older adults experienced very limited high-impact activity. The accelerometry method utilised appeared to be valid based on comparisons between different cohorts and with self-reported...