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A comprehensive fracture prevention strategy in older adults: the European Union Geriatric Medicine Society (EUGMS) statement

Prevention of fragility fractures in older people has become a public health priority, although the most appropriate and cost-effective strategy remains unclear. In the present statement, the Interest Group on Falls and Fracture Prevention of the European Union Geriatric Medicine Society, in collaboration with the International Association of Gerontology and Geriatrics for the ...

Birth Weight, Infant Weight Gain, and Cause-specific Mortality: The Hertfordshire Cohort Study

Low birth weight, a marker of adverse intrauterine circumstances, is known to be associated with a range of disease outcomes in later life, including coronary heart disease, hypertension, type 2 diabetes, and osteoporosis. However, it may also decrease the risk of other common conditions, most notably neoplastic disease. The authors describe the associations between birth weight, ...

Scleroderma and Solvent Exposure among Women

Exposure to solvents has been reported to increase the risk of scleroderma. The authors investigated the relation between exposures to solvents in occupational and hobby settings and the development of scleroderma among women in a case-control study with population-based controls in Michigan (1980–1991) and Ohio (1980–1992). A total of 660 cases and 2,227 frequency-matched controls ...

Potential Risk Factors for Undifferentiated Connective Tissue Disease among Women: Implanted Medical Devices

A case-control study was conducted among 205 women in Michigan and Ohio who were diagnosed with undifferentiated connective tissue disease (UCTD) to investigate the significance of self-reported past exposures to implanted silicone-containing or non-silicone-containing medical devices. The 205 UCTD cases were compared with 2,095 controls who were sampled by random digit dialing. ...

Factors Associated with Osteoarthritis of the Hip and Knee in Hong Kong Chinese: Obesity, Joint Injury, and Occupational Activities

In 1998, a case-control study was conducted in Hong Kong on hospital patients with osteoarthritis of the hip (n = 138) and osteoarthritis of the knee (n = 658). Age- and sex-matched controls were recruited consecutively from general practice clinics in the same region. The following three risk factors were found to be associated with osteoarthritis of both the hip and the knee: ...

Petroleum Distillate Solvents as Risk Factors for Undifferentiated Connective Tissue Disease (UCTD)

Occupational solvent exposure may increase the risk of connective tissue disease (CTD). The objective of this case-control study was to investigate the relation between undifferentiated connective tissue disease (UCTD) and solvent exposure in Michigan and Ohio. Women were considered to have UCTD if they did not meet the American College of Rheumatology classification criteria for ...

Anthropometric Measurements and Vertebral Deformities

To investigate the association between anthropometric indices and morphometrically determined vertebral deformity, the authors carried out a cross-sectional study using data from the European Vertebral Osteoporosis Study (EVOS), a population-based study of vertebral osteoporosis in 36 European centers from 19 countries. A total of 16,047 EVOS subjects were included in this ...

Endothelial Function: The Impact of Objective and Subjective Socioeconomic Status on Flow-Mediated Dilation

Background Although objective and subjective indicators of socioeconomic status (SES) are linked to cardiovascular disease (CVD), little is known about their relationship to endothelial dysfunction, which often precedes CVD. Purpose This study examined how objective and subjective SES relate to brachial artery flow-mediated dilation (FMD). Methods FMD was assessed in 72 healthy ...

UK clinical guideline for the prevention and treatment of osteoporosis

50 years in the UK . Maturitas 62 : 105 - 108 4. Compston J , Bowring C , Cooper A , Cooper C , Davies C , Francis R , Kanis JA , Marsh D , McCloskey EV , Reid DM , Selby P , National Osteoporosis

Osteoporosis in the European Union: a compendium of country-specific reports

, Stockholm, Sweden 4 E. V. McCloskey Academic Unit of Bone Metabolism, Northern General Hospital , Sheffield, UK 5 J. Stenmark International Osteoporosis Foundation , Nyon, Switzerland 6 C. Cooper NIHR ... Musculoskeletal Biomedical Research Unit, Institute of Musculoskeletal Sciences, University of Oxford , Oxford, UK 7 C. Cooper MRC Lifecourse Epidemiology Unit, University of Southampton , Southampton, UK 8 C

Osteoporosis in the European Union: medical management, epidemiology and economic burden

, Sweden 4 E. V. McCloskey Academic Unit of Bone Metabolism, Northern General Hospital, University of Sheffield , Sheffield, UK 5 J. Stenmark International Osteoporosis Foundation , Nyon, Switzerland 6 C

Claudin 1 expression in basal-like breast cancer is related to patient age

Background Defects in tight junctions, gate-keepers of the integrity of the epidermal barrier function, are known to contribute to cancer development. As such, enhancing our understanding of how the expression of proteins involved in these junctions is regulated in cancer, remains a priority. Although the expression of one of these proteins, claudin 1, is down regulated in most ...

Skeletal muscle morphology in sarcopenia defined using the EWGSOP criteria: findings from the Hertfordshire Sarcopenia Study (HSS)

Background Sarcopenia is defined as the loss of muscle mass and function with age and is associated with decline in mobility, frailty, falls and mortality. There is considerable interest in understanding the underlying mechanisms. Our aim was to characterise muscle morphology changes associated with sarcopenia among community dwelling older men. Methods One hundred and five men ...

A longitudinal cohort study of HIV ‘treatment as prevention’ in gay, bisexual and other men who have sex with men: the Treatment with Antiretrovirals and their Impact on Positive And Negative men (TAIPAN) study protocol

Background Australia has increased coverage of antiretroviral treatment (ART) over the past decade, reaching 73% uptake in 2014. While ART reduces AIDS-related deaths, accumulating evidence suggests that it could also bolster prevention efforts by reducing the risk of HIV transmission (‘treatment as prevention’). While promising, evidence of community-level impact of treatment as ...

Switch therapy in hospitalized patients with community-acquired pneumonia: Tigecycline vs. Levofloxacin

Background Switch therapy is a management approach combining early discontinuation of intravenous (IV) antibiotics, switch to oral antibiotics, and early hospital discharge. This analysis compares switch therapy using tigecycline versus levofloxacin in hospitalized patients with community-acquired pneumonia (CAP). Methods A prospective, randomized, double-blind, Phase 3 clinical ...

Translating an early childhood obesity prevention program for local community implementation: a case study of the Melbourne InFANT Program

Background While there is a growing interest in the field of research translation, there are few published examples of public health interventions that have been effectively scaled up and implemented in the community. This paper provides a case study of the community-wide implementation of the Melbourne Infant, Feeding, Activity and Nutrition Trial (InFANT), an obesity prevention ...

Non-invasive Assessment of Lower Limb Geometry and Strength Using Hip Structural Analysis and Peripheral Quantitative Computed Tomography: A Population-Based Comparison

. J. Denison, K. A. Jameson, M. H. Edwards, A. A. Sayer, P. Taylor, C. Cooper, E. M. Dennison) declare no conflict of interest Human and Animal Rights and Informed Consent Ethical permission for the

Use of β-Blockers and the Risk of Hip/Femur Fracture in the United Kingdom and The Netherlands

Data from in vivo studies have indicated a role for β-blockers in the prevention of bone loss. Some epidemiological studies have found protective effects of β-blockers on fracture risk. However, there is limited information on the association with cumulative dose and type of β-blockers used. We conducted two case-control studies using data from the UK General Practice Research ...

Sex Hormones and Osteoporosis in Men

) Effect of testosterone and estradiol in a man with aromatase deficiency . N Engl J Med 337 : 91 - 95 30. Anderson FH , Francis RM , Hindmarsh P , Fall C , Cooper C ( 1996 ) Serum oestradiol in osteoporotic

Epidemiology of Sarcopenia: Determinants Throughout the Lifecourse

Sarcopenia is an age-related syndrome characterised by progressive and generalised loss of skeletal muscle mass and strength; it is a major contributor to the risk of physical frailty, functional impairment in older people, poor health-related quality of life and premature death. Many different definitions have been used to describe sarcopenia and have resulted in varying estimates ...