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113 papers found.
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A Post-Burst Afterdepolarization Is Mediated by Group I Metabotropic Glutamate Receptor-Dependent Upregulation of Cav2.3 R-Type Calcium Channels in CA1 Pyramidal Neurons

The excitability of hippocampal pyramidal neurons is regulated by activation of metabotropic glutamate receptors, an effect that is mediated by modulation of R-type calcium channels.

A Randomized Study of the Safety and Antiretroviral Activity of Hydroxyurea Combined with Didanosine in Persons Infected with Human Immunodeficiency Virus Type 1

This randomized open-label trial of human immunodeficiency virus type 1-infected persons compared safety and efficacy for 38 patients receiving hydroxyurea/didanosine combination therapy with findings in 42 persons given didanosine monotherapy for 12 weeks, followed by 12 weeks of hydroxyurea/didanosine combination therapy for all patients. Week 12 on-treatment group comparisons ...

A comprehensive fracture prevention strategy in older adults: the European Union Geriatric Medicine Society (EUGMS) statement

Prevention of fragility fractures in older people has become a public health priority, although the most appropriate and cost-effective strategy remains unclear. In the present statement, the Interest Group on Falls and Fracture Prevention of the European Union Geriatric Medicine Society, in collaboration with the International Association of Gerontology and Geriatrics for the ...

A deep Chandra survey of the Groth Strip – II. Optical identification of the X-ray sources

In this paper, we discuss the optical and X-ray spectral properties of the sources detected in a single 200-ks Chandra pointing in the Groth-Westphal Strip region. A wealth of optical photometric and spectroscopic data are available in this field providing optical identifications and redshift determinations for the X-ray population. The optical photometry and spectroscopy used here ...

A longitudinal cohort study of HIV ‘treatment as prevention’ in gay, bisexual and other men who have sex with men: the Treatment with Antiretrovirals and their Impact on Positive And Negative men (TAIPAN) study protocol

Background Australia has increased coverage of antiretroviral treatment (ART) over the past decade, reaching 73% uptake in 2014. While ART reduces AIDS-related deaths, accumulating evidence suggests that it could also bolster prevention efforts by reducing the risk of HIV transmission (‘treatment as prevention’). While promising, evidence of community-level impact of treatment as ...

A novel accelerometer-based method to describe day-to-day exposure to potentially osteogenic vertical impacts in older adults: findings from a multi-cohort study

Summary This observational study assessed vertical impacts experienced in older adults as part of their day-to-day physical activity using accelerometry and questionnaire data. Population-based older adults experienced very limited high-impact activity. The accelerometry method utilised appeared to be valid based on comparisons between different cohorts and with self-reported ...

A reappraisal of generic bisphosphonates in osteoporosis

Sheffield Medical School , Beech Hill Road, Sheffield S10 2RX, UK 2 C. Cooper NIHR Musculoskeletal Biomedical Research Unit, University of Oxford , Oxford, UK 3 C. Cooper MRC Lifecourse Epidemiology Unit ... receives consulting fees, paid advisory boards and/or lecture fees from most companies concerned with bone disease. C Cooper receives consulting fees and paid advisory boards for Alliance for Better Bone

A study of the gas–star formation relation over cosmic time*

We use the first systematic data sets of CO molecular line emission in z∼ 1–3 normal star-forming galaxies (SFGs) for a comparison of the dependence of galaxy-averaged star formation rates on molecular gas masses at low and high redshifts, and in different galactic environments. Although the current high-z samples are still small and biased towards the luminous and massive tail of ...

A systematic review of hip fracture incidence and probability of fracture worldwide

HP, Hiligsmann M, Kanis JA, Lau E, Lewiecki EM, Lips P, Lorenc R, McCloskey E, Ortolani S, Papaioannou A, Silverman S, Yoshimura N, and Szulc P 2 C. Cooper MRC Lifecourse Epidemiology Unit, University ... Cummings (China), B Abrahamsen (Denmark), CH Orces (Ecuador), R Sund and H Kroger (Finland), Kristin Siggeirsdottir and Vilmundur Gudnason (Iceland), D Dhanwal and C Cooper (India), Errol Hutagalung and

Absence of evidence is not evidence of absence: the colour–density relation at fixed stellar mass persists to z∼ 1*

M. C. Cooper et al. E-mail: 0 0 Some of the data presented herein were obtained at the W. M. Keck Ob- servatory, which is operated as a scientific partnership among the California Institute of

Activation of Porcine Cytomegalovirus, but Not Porcine Lymphotropic Herpesvirus, in Pig-to-Baboon Xenotransplantation

Tissue-invasive disease due to porcine cytomegalovirus (PCMV) has been demonstrated after pig-to-baboon solid-organ xenotransplantation. Porcine lymphotropic herpesvirus (PLHV)-1 is associated with B cell proliferation and posttransplant lymphoproliferative disorder after allogeneic bone marrow transplantation in swine but has not been observed in pig-to-primate ...

Adverse Outcome Analyses of Observational Data: Assessing Cardiovascular Risk in HIV Disease

Clinical decisions are ideally based on randomized trials but must often rely on observational data analyses, which are less straightforward and more influenced by methodology. The authors, from a series of expert roundtables convened by the Forum for Collaborative HIV Research on the use of observational studies to assess cardiovascular disease risk in human immunodeficiency virus ...

Anthropometric Measurements and Vertebral Deformities

To investigate the association between anthropometric indices and morphometrically determined vertebral deformity, the authors carried out a cross-sectional study using data from the European Vertebral Osteoporosis Study (EVOS), a population-based study of vertebral osteoporosis in 36 European centers from 19 countries. A total of 16,047 EVOS subjects were included in this ...

Antipsychotic use and the risk of hip/femur fracture: a population-based case–control study

, Utrecht, The Netherlands 1 ) Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Utrecht University , Utrecht, The Netherlands 2 C. Cooper Institute of

Automated morphological classification of Sloan Digital Sky Survey red sequence galaxies

In the last decade, the advent of enormous galaxy surveys has motivated the development of automated morphological classification schemes to deal with large data volumes. Existing automated schemes can successfully distinguish between early- and late-type galaxies and identify merger candidates, but are inadequate for studying detailed morphologies of red sequence galaxies. To fill ...

Available alternative incentives modulate anticipatory nucleus accumbens activation

A reward or punishment can seem better or worse depending on what else might have happened. Little is known, however, about how neural representations of an anticipated incentive might be influenced by the available alternatives. We used event-related FMRI to investigate the activation in the nucleus accumbens (NAcc), while we varied the available alternative incentives in a ...

Behavioral economics: implications for regulatory behavior

James C. Cooper 0 William E. Kovacic 0 0 J. C. Cooper Law & Economics Center, George Mason University School of Law , Arlington, VA, USA Behavioral economics (BE) examines the implications for

Birth Weight, Infant Weight Gain, and Cause-specific Mortality: The Hertfordshire Cohort Study

Low birth weight, a marker of adverse intrauterine circumstances, is known to be associated with a range of disease outcomes in later life, including coronary heart disease, hypertension, type 2 diabetes, and osteoporosis. However, it may also decrease the risk of other common conditions, most notably neoplastic disease. The authors describe the associations between birth weight, ...

Capture the Fracture: a Best Practice Framework and global campaign to break the fragility fracture cycle

Southampton , Southampton, UK 4 C. Cooper NIHR Musculoskeletal Biomedical Research Unit, University of Oxford , Oxford, UK 5 A. R. McLellan Gardiner Institute, Western Infirmary , Glasgow, UK 6 P. J. Mitchell