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Ranges of phenotypic flexibility in healthy subjects

Background A key feature of metabolic health is the ability to adapt upon dietary perturbations. A systemic review defined an optimal nutritional challenge test, the “PhenFlex test” (PFT). Recently, it has been shown that the PFT enables the quantification of all relevant metabolic processes involved in maintaining or regaining homeostasis of metabolic health. Furthermore, it was...

Matrix correlations for high-dimensional data: the modified RV-coefficient

Motivation: Modern functional genomics generates high-dimensional datasets. It is often convenient to have a single simple number characterizing the relationship between pairs of such high-dimensional datasets in a comprehensive way. Matrix correlations are such numbers and are appealing since they can be interpreted in the same way as Pearson's correlations familiar to...

Dynamic metabolomic data analysis: a tutorial review

H. Pijl F. Roelfsema Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center , Leiden, The Netherlands 1 S. Bijlsma C. M. Rubingh R. H. Jellema J. van der Greef TNO